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Start Over Author "Barr, Ronald" Journal journal of the american academy of dermatology
21 results on '"Barr, Ronald"'

4. Subcutaneous myospherulosis

Author

Waldman, James S., Barr, Ronald J., Espinoza, Froilan P., and Simmons, Gregory E.

Subjects
Skin -- Injuries, Penicillin -- Adverse and side effects, Cysts -- Analysis, Erythrocytes -- Abnormalities, Health
Abstract

Myospherulosis is a rare disorder of the muscle and tissue underlying the skin which was thought to result from infection by an endosporulating, or spore-producing, fungus. However, the skin lesion, resembling a sac of marbles, actually results from changes in red blood cells, and is accompanied by bodily reactions to foreign invading substances. Myospherulosis may occur in the nose, ear, and upper jaw. A case is described of a 57-year-old woman, who received a penicillin injection 40 years before she developed a mass in the right buttock. The diagnosis of myospherulosis was confirmed by microscopic tissue examination which revealed the presence of endospore-like structures and the accumulation of plasma cells, lymphocytes, and giant cells, a cell normally involved in the body's response to injury. The mass was removed surgically, and the patient was discharged the next day. It was suggested that the ointment containing the penicillin entrapped the red blood cells, causing cell death and pores in the red cell membrane. Histiocytes and giant cells accumulate in response to the tissue injury. The membranes from dead cells may fuse together to form the sac-like structure in myospherulosis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1989

15. Reply

Author

Brice, Sylvia L., primary, Barr, Ronald J., additional, and Rattet, Jeffrey P., additional

Published
1981
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