10 results on '"Gallardo, F."'
Search Results
2. Diffuse plane xanthoma: Clinicopathologic study of 8 cases
- Author
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Marcoval, J., Moreno, A., Bordas, X., Gallardo, F., and Peyri, J.
- Abstract
Background: Diffuse plane xanthoma (DPX) usually has been described in association with a reticuloendothelial disease. However, the incidence of an underlying disease and its relation to clinical and histopathologic features have not been previously described. Objective: We describe the clinicopathologic features of a series of patients with DPX. Methods: Eight patients with DPX were diagnosed and studied between 1987 and 1996. Results: Three of the 8 patients had a reticuloendothelial disease (benign monoclonal gammopathy in 2 and chronic myelomonocytic leukemia in 1). These 3 patients had larger cutaneous lesions and involvement of trunk and extremities. Histologic examination showed only foamy macrophages in 2 of the 8 patients. The remainder exhibited macrophages, foamy histiocytes, lymphocytes, and Touton cells. Conclusion: The incidence of underlying disease associated with DPX seems to be lower than expected. However, patients with DPX should be observed for the potential occurrence of an associated condition. (J Am Acad Dermatol 1998;39:439-42.)
- Published
- 1998
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3. Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients.
- Author
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López-Lerma I, Peñate Y, Gallardo F, Martí RM, Mitxelena J, Bielsa I, Velasco-Tamariz V, Yanguas-Bayona JI, Sánchez-Sambucety P, García-Patos V, Ortiz-Romero PL, Pujol RM, and Estrach T
- Subjects
- Adult, Aged, Chemoradiotherapy methods, Cohort Studies, Disease-Free Survival, Female, Humans, Lymphoma, T-Cell diagnostic imaging, Lymphoma, T-Cell mortality, Lymphoma, T-Cell, Cutaneous diagnostic imaging, Lymphoma, T-Cell, Cutaneous mortality, Male, Middle Aged, Panniculitis diagnostic imaging, Panniculitis mortality, Positron Emission Tomography Computed Tomography methods, Retrospective Studies, Risk Assessment, Sampling Studies, Skin Neoplasms diagnostic imaging, Skin Neoplasms mortality, Spain, Survival Analysis, Young Adult, Lymphoma, T-Cell pathology, Lymphoma, T-Cell therapy, Lymphoma, T-Cell, Cutaneous pathology, Lymphoma, T-Cell, Cutaneous therapy, Panniculitis pathology, Panniculitis therapy, Skin Neoplasms pathology, Skin Neoplasms therapy
- Abstract
Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma of mature cytotoxic T cells. Initially, patients with SPTCL were treated with doxorubicin-based polychemotherapy., Objective: To analyze clinical, biologic, immunophenotypical, molecular, imaging, treatment, and outcome data reflecting the current state of knowledge., Methods: A retrospective multicenter study of 16 patients with SPTCL that was diagnosed between 1996 and 2016., Results: The female-to-male ratio was 1.7. The median age at diagnosis was 46.5 years. Patients presented with multiple nodular or plaque-like lesions preferentially affecting the legs and/or trunk. Histopathology typically showed a lobular panniculitis with individual adipocytes surrounded by atypical lymphocytes, usually with a CD3
+ , CD4- , CD8+ , CD56- , TIA1 cytotoxic granule associated RNA binding protein 1-positive phenotype and high proliferation rate. SPTCL was associated with autoimmune diseases in 25% of patients, and with the development of hemophagocytic syndrome in 18% of patients. Oral steroids alone or in combination with low-dose methotrexate or cyclosporine A were the most common initial treatment, achieving a complete response in 85% of the treated patients. The median follow-up time was 14 months. The 5-year disease-specific survival rate was 85.7%., Limitations: This was a retrospective study., Conclusions: SPTCL has an excellent prognosis. Immunosuppressive agents can be considered for first-line treatment., (Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
4. Primary cutaneous marginal zone B-cell lymphoma: response to treatment and disease-free survival in a series of 137 patients.
- Author
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Servitje O, Muniesa C, Benavente Y, Monsálvez V, Garcia-Muret MP, Gallardo F, Domingo-Domenech E, Lucas A, Climent F, Rodriguez-Peralto JL, Ortiz-Romero PL, Sandoval J, Pujol RM, and Estrach MT
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy, Disease-Free Survival, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Staging, Radiotherapy, Remission Induction, Retrospective Studies, Survival Rate, Young Adult, Lymphoma, B-Cell, Marginal Zone pathology, Lymphoma, B-Cell, Marginal Zone therapy, Neoplasm Recurrence, Local pathology, Skin Neoplasms pathology, Skin Neoplasms therapy
- Abstract
Background: Primary cutaneous marginal zone B-cell lymphomas are low-grade lymphomas running an indolent course. Skin relapses have been frequently reported but little information about disease-free survival (DFS) is available., Objective: We sought to evaluate relapse rate and DFS in patients with primary cutaneous marginal zone B-cell lymphomas., Methods: Clinical features, European Organization for Research and Treatment of Cancer/International Society for Cutaneous Lymphomas stage, light chain restriction, clonality, treatments, skin relapses, DFS, stage progression, extracutaneous disease, and outcome are analyzed in a series of 137 patients., Results: Patients were classified as solitary lesion (T1) (n = 70; 51%), regional skin involvement (T2) (n = 40; 29%), and generalized skin lesions (T3) (n = 27; 20%). Surgical excision, local radiotherapy, or a combination were the initial treatment in 118 patients (86%). In 121 of 137 patients (88%) a complete remission was observed after initial treatment, including 99 of 106 patients (93%) with solitary or localized disease and 22 of 31 patients (71%) with multifocal lesions. Cutaneous relapses were observed in 53 patients (44%). Median DFS was 47 months. Patients with multifocal lesions or T3 disease showed higher relapse rate and shorter DFS. No significant differences were observed between surgery and radiotherapy, but surgery alone was associated with more recurrences at initial site. Overall survival at 5 and 10 years was 93%. Six patients (4%) developed extracutaneous disease during follow-up., Limitations: This was a case series retrospective study., Conclusion: Our results support long-term follow-up in patients with primary cutaneous marginal zone B-cell lymphomas. Disseminated skin lesions have higher relapse rate and shorter DFS suggesting further investigation on systemic therapies in such a group of patients., (Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.)
- Published
- 2013
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5. Miliary and agminated papules as clinical presentation of a secondary cutaneous follicular lymphoma.
- Author
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López Aventín D, García M, Pedro C, Pujol RM, and Gallardo F
- Subjects
- Female, Humans, Male, Facial Neoplasms diagnosis, Lymphoma, Follicular diagnosis, Skin Neoplasms diagnosis
- Published
- 2012
- Full Text
- View/download PDF
6. Folliculotropic mycosis fungoides: clinicopathological features and outcome in a series of 20 cases.
- Author
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Muniesa C, Estrach T, Pujol RM, Gallardo F, Garcia-Muret P, Climent J, and Servitje O
- Subjects
- Adult, Aged, Aged, 80 and over, Bexarotene, Combined Modality Therapy, Female, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Head and Neck Neoplasms radiotherapy, Humans, Male, Middle Aged, Mycosis Fungoides diagnosis, Mycosis Fungoides pathology, Mycosis Fungoides radiotherapy, PUVA Therapy, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Skin Neoplasms radiotherapy, Tetrahydronaphthalenes therapeutic use, Treatment Outcome, Head and Neck Neoplasms therapy, Mycosis Fungoides therapy, Skin Neoplasms therapy
- Abstract
Background: Folliculotropic mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma in which the neoplastic T lymphocytes display tropism for the follicular epithelium., Objectives: To better categorize this rare form of cutaneous T-cell lymphoma we evaluated the clinical, pathological, and immunophenotypic findings, and the response to therapy and course of the disease., Methods: Folliculotropic MF cases were selected from the registry of the Thematic Network of Cutaneous Lymphoma of Barcelona (Spain) from 1988 to 2007., Results: Twenty patients (11 male, 9 female) with a mean age of 54 years were included. Mean follow-up time was 43 months. The most common sites of involvement were the head and neck (80%), upper extremities, and thorax. Infiltrated plaques (55%), acneiform lesions (comedo-like and epidermal cysts) (45%), and follicular keratosis-pilaris-like lesions (45%) were the more prominent features. Histopathological findings included selective infiltration of the follicular epithelium by atypical lymphocytes in all cases. Mucinous degeneration of the follicular epithelium occurred in 60% of cases. Psoralen plus ultraviolet A therapy was the treatment of choice in the majority of patients, but these patients did not respond as well as patients with classic MF. Radiotherapy (local or total skin electron beam) was found to be the most effective treatment. A good response to bexarotene was seen in some patients., Limitation: This was a case series descriptive study., Conclusions: Folliculotropic MF is a rare but well-defined clinicopathological variant of MF. Although refractory to standard therapies used in classic MF, most of our patients showed only slow disease progression., (Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
7. Annually recurring erythema annulare centrifugum: a distinct entity?
- Author
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García Muret MP, Pujol RM, Gimenez-Arnau AM, Barranco C, Gallardo F, and Alomar A
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- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Recurrence, Seasons, Erythema pathology
- Abstract
Four patients presenting a peculiar clinical variant of erythema annulare centrifugum are reported. The lesions were clinically and histopathologically indistinguishable from classic superficial erythema annulare centrifugum but constant annual and seasonal recurrences for many years or decades were observed. No clear precipitating factor could be identified. No associated symptoms were present and the eruption regressed spontaneously after a variable period of days to months. Annually recurring erythema annulare centrifugum seems to represent a rare distinct clinical entity that has received little attention in literature. Clinicopathologic features of this peculiar clinical disorder and the differential diagnosis with other recurrent seasonal eruptions are reviewed.
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- 2006
- Full Text
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8. Invisible mycosis fungoides: a diagnostic challenge.
- Author
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Pujol RM, Gallardo F, Llistosella E, Blanco A, Bernadó L, Bordes R, Nomdedeu JF, and Servitje O
- Subjects
- Aged, Female, Humans, Immunohistochemistry, Mycosis Fungoides complications, Mycosis Fungoides metabolism, Mycosis Fungoides pathology, Polymerase Chain Reaction, Pruritus etiology, Skin pathology, Skin Neoplasms complications, Skin Neoplasms metabolism, Skin Neoplasms pathology, Mycosis Fungoides diagnosis, Skin Neoplasms diagnosis
- Abstract
We describe a 76-year-old woman who had persistent generalized pruritus as the only cutaneous manifestation of a cutaneous T-cell lymphoma (mycosis fungoides). No cutaneous lesions were observed throughout the patient's course. Skin biopsy specimens obtained from normal-looking pruritic skin revealed a discrete perivascular lymphocytic infiltrate in the upper dermis and focal intraepidermal clusters of atypical lymphoid cells (Pautrier's microabscesses). PCR analysis of TCR-gamma gene disclosed a monoclonal T-cell rearrangement. Sequencing of the PCR monoclonal product identified the J(8)V(2)C(2) TCR gene rearrangement. This observation illustrates the existence of a peculiar and exceedingly rare form of mycosis fungoides characterized only by persistent pruritus unresponsive to several therapeutic approaches. The diagnostic difficulties of this rare variant are stressed.
- Published
- 2002
- Full Text
- View/download PDF
9. Invisible mycosis fungoides: A diagnostic challenge.
- Author
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Pujol RM, Gallardo F, Llistosella E, Blanco A, Bernadó L, Bordes R, Nomdedeu JF, and Servitje O
- Subjects
- Aged, Female, Humans, Immunohistochemistry, Mycosis Fungoides complications, Mycosis Fungoides metabolism, Mycosis Fungoides pathology, Polymerase Chain Reaction, Pruritus etiology, Skin pathology, Skin Neoplasms complications, Skin Neoplasms metabolism, Skin Neoplasms pathology, Mycosis Fungoides diagnosis, Skin Neoplasms diagnosis
- Abstract
We describe a 76-year-old woman who presented persistent generalized pruritus as the only cutaneous manifestation of a cutaneous T-cell lymphoma (mycosis fungoides). No cutaneous lesions were observed throughout the patient's course. Skin biopsies obtained from normal-looking pruritic skin revealed a discrete perivascular lymphocytic infiltrate in the upper dermis and focal intraepidermal clusters of atypical lymphoid cells (Pautrier's microabscesses). PCR analysis of TCR-gamma gene disclosed a monoclonal T-cell rearrangement. Sequencing of the PCR monoclonal product identified the J(8)V(2)C(2) TCR gene rearrangement. This observation illustrates the existence of a peculiar and exceedingly rare form of mycosis fungoides characterized only by persistent pruritus unresponsive to several therapeutic approaches. The diagnostic difficulties of this rare variant are stressed.
- Published
- 2000
- Full Text
- View/download PDF
10. Systemic lupus erythematosus after eosinophilic fasciitis: a case report.
- Author
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Gallardo F, Vadillo M, Mitjavila F, and Servitje O
- Subjects
- Adult, Autoimmune Diseases pathology, Biopsy, Eosinophilia pathology, Fascia pathology, Fasciitis pathology, Female, Humans, Lupus Erythematosus, Systemic pathology, Muscles pathology, Time Factors, Autoimmune Diseases complications, Eosinophilia complications, Fasciitis complications, Lupus Erythematosus, Systemic etiology
- Published
- 1998
- Full Text
- View/download PDF
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