Author: "Javier Menárguez" / Journal: journal of the american academy of dermatology - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Javier Menárguez" Journal journal of the american academy of dermatology

Author: Alfonso Gómez-Pineda, Carlos M. González-Herrada, Tomás Pozo-Román, Pablo Lázaro-Ochaita, and F. Javier Menárguez-Palanca
Subjects: Pathology, medicine.medical_specialty, Leukemic Infiltration, Myeloid, medicine.diagnostic_test, business.industry, Chronic myelomonocytic leukemia, Histology, Dermatology, Disease, medicine.disease, medicine.anatomical_structure, hemic and lymphatic diseases, Skin biopsy, medicine, Bone marrow, business, Reticular Dermis
Abstract: We report a case, in a 74-year-old man, of chronic myelomonocytic leukemia (CMML) that showed cutaneous involvement in its terminal phase. The patient developed a nodular eruption with an irregular distribution over the entire skin surface. Histology showed an acute leukemic infiltration in the reticular dermis. We were able to demonstrate cells with intermediate myeloid and monocytic characteristics ("paramyeloid cells") in the skin biopsy and in bone marrow smears. There have been only four patients reported previously with similar clinical findings. In one of them the cutaneous eruption heralded an aggressive clinical shift of the disease, as in our case. The present case confirms the utility of skin biopsy in similar cases for predicting the evolution of the disease.
Published: 1985

Author: T, Pozo-Román, F, Javier Menárguez-Palanca, A, Gómez-Pineda, C M, González-Herrada, and P, Lázaro-Ochaita
Subjects: Male, Blastomeres, Leukemia, Myeloid, Acute, Cell Transformation, Neoplastic, Skin Neoplasms, Bone Marrow, Leukemia, Myeloid, Humans, Aged
Abstract: We report a case, in a 74-year-old man, of chronic myelomonocytic leukemia (CMML) that showed cutaneous involvement in its terminal phase. The patient developed a nodular eruption with an irregular distribution over the entire skin surface. Histology showed an acute leukemic infiltration in the reticular dermis. We were able to demonstrate cells with intermediate myeloid and monocytic characteristics ("paramyeloid cells") in the skin biopsy and in bone marrow smears. There have been only four patients reported previously with similar clinical findings. In one of them the cutaneous eruption heralded an aggressive clinical shift of the disease, as in our case. The present case confirms the utility of skin biopsy in similar cases for predicting the evolution of the disease.
Published: 1985

Author: Pozo-Román T, Javier Menárguez-Palanca F, Gómez-Pineda A, González-Herrada CM, and Lázaro-Ochaita P
Subjects: Aged, Blastomeres pathology, Bone Marrow pathology, Humans, Leukemia, Myeloid pathology, Male, Cell Transformation, Neoplastic pathology, Leukemia, Myeloid, Acute pathology, Skin Neoplasms pathology
Abstract: We report a case, in a 74-year-old man, of chronic myelomonocytic leukemia (CMML) that showed cutaneous involvement in its terminal phase. The patient developed a nodular eruption with an irregular distribution over the entire skin surface. Histology showed an acute leukemic infiltration in the reticular dermis. We were able to demonstrate cells with intermediate myeloid and monocytic characteristics ("paramyeloid cells") in the skin biopsy and in bone marrow smears. There have been only four patients reported previously with similar clinical findings. In one of them the cutaneous eruption heralded an aggressive clinical shift of the disease, as in our case. The present case confirms the utility of skin biopsy in similar cases for predicting the evolution of the disease.
Published: 1985
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