Search

Your search keyword '"Dongjoon Im"' showing total 1 results
Start Over Author "Dongjoon Im" Journal journal of the american chemical society
1 results on '"Dongjoon Im"'

1. Kinetic Modulation of Amyloid-β (1-42) Aggregation and Toxicity by Structure-Based Rational Design

Author

Dongjoon Im, Chae Eun Heo, Myung Kook Son, Chae Ri Park, Hugh I. Kim, and Jeong-Mo Choi

Subjects
Amyloid beta-Peptides, Cell Survival, General Chemistry, Molecular Dynamics Simulation, Biochemistry, Catalysis, Peptide Fragments, Kinetics, Colloid and Surface Chemistry, Solubility, X-Ray Diffraction, Cell Line, Tumor, Ion Mobility Spectrometry, Scattering, Small Angle, Mutagenesis, Site-Directed, Humans, Amino Acid Sequence, Protein Multimerization, Dimerization
Abstract

Several point mutations can modulate protein structure and dynamics, leading to different natures. Especially in the case of amyloidogenic proteins closely related to neurodegenerative diseases, structural changes originating from point mutations can affect fibrillation kinetics. Herein, we rationally designed mutant candidates to inhibit the fibrillation process of amyloid-β with its point mutants through multistep

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results