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2 results on '"Ignacio Vayá"'

1. Electronic excitation energy transfer between nucleobases of natural DNA

Author

Yuri A. Berlin, Thomas Gustavsson, Ignacio Vayá, Dimitra Markovitsi, Thierry Douki, Laboratoire Francis PERRIN (LFP - URA 2453), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lésions des Acides Nucléiques (LAN), Service de Chimie Inorganique et Biologique (SCIB - UMR E3), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry, and Northwestern University

Subjects
Electrons, Fluorescence Polarization, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Biochemistry, Catalysis, Fluorescence spectroscopy, Nucleobase, chemistry.chemical_compound, Colloid and Surface Chemistry, QUIMICA ORGANICA, QUIMICA ANALITICA, 010405 organic chemistry, Chemistry, General Chemistry, DNA, Fluorescence, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Spectrometry, Fluorescence, Energy Transfer, Excited state, Femtosecond, Atomic physics, Fluorescence anisotropy, Excitation
Abstract

[EN] Transfer of the electronic excitation energy in calf thymus DNA is studied by time-resolved fluorescence spectroscopy. The fluorescence anisotropy, after an initial decay starting on the femtosecond time scale, dwindles down to ca. 0.1. The in-plane depolarized fluorescence decays are described by a stretched exponential law. Our observations are consistent with one-dimensional transfer mediated by charge-transfer excited states., The French Agency for Research (ANR-10-BLAN-0809-01), the Conselleria de Educacion-Generalitat Valenciana (VALi+D program to I.V., No. 2010033), and ONR/MURI (Y.B.) are acknowledged for financial support.

Published
2012
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2. Triplet excited States as chiral reporters for the binding of drugs to transport proteins

Author

Ignacio Vayá, M. Consuelo Jiménez, and Miguel A. Miranda

Subjects
High affinity binding, Stereochemistry, education, macromolecular substances, Electronic structure, Biochemistry, Catalysis, Colloid and Surface Chemistry, Prostaglandin-Endoperoxide Synthase, QUIMICA ORGANICA, medicine, Humans, Binding site, Serum Albumin, Binding Sites, Photolysis, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Stereoisomerism, General Chemistry, Human serum albumin, Transport protein, Flurbiprofen, Excited state, Flash photolysis, Carrier Proteins, medicine.drug, Protein Binding
Abstract

[EN] The triplet excited state of flurbiprofen methyl ester (FBPMe) has been used as a chiral reporter for the two binding sites of human serum albumin (HSA). The occupation level of the binding sites has been estimated from regression analysis of the triplet decays at several [FBPMe]/[HSA] ratios. The data agree with two high affinity binding sites (I and II) that are populated to a different extent. A remarkable stereodifferentiation has been found in the drug triplet lifetimes within the protein microenvironment., The UPV (Grant PI 2003-0522 and fellowship to I.V.), the MEC (Grant CTQ2004-03811), and Generalitat Valenciana (Grant GV2004-0536 and Grupos03/082) are gratefully acknowledged for financial support.

Published
2005

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