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Your search keyword '"Mezo, Adam"' showing total 5 results
Start Over Author "Mezo, Adam" Journal journal of the american chemical society
5 results on '"Mezo, Adam"'

2. Discovery and characterization of a discretely folded homotrimeric beta-beta-alpha peptide

Author

Mezo, Adam R., Ottesen, Jennifer J., and Imperiali, Barbara

Subjects
Peptides -- Separation, Chemistry
Abstract

It has been possible to identify a new loop-truncated form of a beta-beta-alpha peptide that creates a well-defined homotrimer in water. The removal of two amino acids in the loop region of the monomer was vital to switching the motif to a discrete oligomeric state.

Published
2001

5. Cavitands are effective templates for inducing stability and nativelike structure in de novo four-helix bundles

Author

Mezo, Adam R. and Sherman, John C.

Subjects
Protein folding -- Research, Proteins -- Conformation, Chemistry
Abstract

The design, synthesis and characterization of eight cavitand-based de novo four-helix bundles are presented. The proteins, each containing the basis sequence EELLKKLEELLKKG, are determined to be highly helical and exhibit extreme stability against the denaturant guanidine hydrochloride (GuHCl). The presence of flexible cavitand-peptide linkers, however, caused the helical structures to become more susceptible to GuHCl denaturation.

Published
1999

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