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Your search keyword '"Schaaper, Roel M."' showing total 4 results
Start Over Author "Schaaper, Roel M." Journal journal of the american chemical society
4 results on '"Schaaper, Roel M."'

1. Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants

Author

Wenjie Ye, Sangaiah, R., Degen, Diana E., Gold, Avram, Jayaraj, K., Koshlap, Karl M., Boysen, Gunnar, Williams, Jason, Tomer, Kenneth B., Mocanu, Viorel, Dicheva, Nedyalka, Parker, Carol E., Schaaper, Roel M., and Ball, Louise M.

Subjects
DNA -- Chemical properties, Methyl groups -- Chemical properties, Oxidation-reduction reaction -- Analysis, Schiff bases -- Chemical properties, Chemistry
Abstract

The oxidation of guanine to 5-carboxamido-5-formamido-2-iminohydantoin (2-Ih) is major transformation in the oxidation of the single-stranded DNA 5-mer d(TTGTT) by m-chloroperbenzoic acid (m-CPBA) and dimenthyldioxirane (DMDO) as a model for peracid oxidants and in the oxidation of the 5-base pair duplex d[(TTGTT).(AACAA)] with DMDO. The 2-Ih base is a pathway-specific lesion generated by peracids and other epoxidizing agents and can be used as a potential biomarker.

Published
2009

2. Reaction mechanism of the [epsilon] subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues

Author

Cisneros, A. Andres, Perera, Lalith, Schaaper, Roel M., Pedersen, Larc C., London, Robert E., Pedersen, Lee G., and Darden, Thomas A.

Subjects
Escherichia coli -- Physiological aspects, Exonucleases -- Structure, Exonucleases -- Chemical properties, Magnesium -- Chemical properties, Magnesium -- Atomic properties, Manganese -- Chemical properties, Quantum theory -- Usage, Chemistry
Abstract

The reaction mechanism for the Escherichia coli exonuclease domain of Pol-III, the [epsilon] subunit, is determined by using the quantum mechanics/molecular mechanics (QM/MM) calculations. The results have shown that [epsilon] is slightly more active with [Mn.sup.2+] than with [Mg.sup.2+] and there are several residues than have major impact on the transition-state (TS) barrier.

Published
2009

3. Iminohydantoin Lesion Induced in DNA by Peracids and Other Epoxidizing Oxidants

Author

Ye, Wenjie, primary, Sangaiah, R., additional, Degen, Diana E., additional, Gold, Avram, additional, Jayaraj, K., additional, Koshlap, Karl M., additional, Boysen, Gunnar, additional, Williams, Jason, additional, Tomer, Kenneth B., additional, Mocanu, Viorel, additional, Dicheva, Nedyalka, additional, Parker, Carol E., additional, Schaaper, Roel M., additional, and Ball, Louise M., additional

Published
2009
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