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Start Over Author "Williams, Daniel M." Journal journal of the american chemical society
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1. Proton demand inversion in a mutant protein tyrosine kinase reaction

Author

Williams, Daniel M. and Cole, Philip A.

Subjects
Phosphorylation -- Research, Mutagenesis -- Research, Tyrosine -- Research, Tyrosine -- Chemical properties, Chemistry
Abstract

The complementarity of site-directed mutagenesis and synthetic substrate analogues are used to investigate the dissociative mechanistic model for protein tyrosine kinase-catalyzed reaction and use of substrate neutral phenol in phosphorylation reaction, instead of chemically more reactive phenoxide anion.

Published
2002

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