Search

Your search keyword '"Peter J. Leary"' showing total 6 results
Start Over Author "Peter J. Leary" Journal journal of the american college of cardiology
6 results on '"Peter J. Leary"'

1. Histamine H 2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk

Author

Steven M. Kawut, Steven Shea, Peter J. Leary, Ryan J. Tedford, Carolina S Masri, Richard A. Kronmal, Eric V. Krieger, Joao A.C. Lima, Susan R. Heckbert, Michael R. Bristow, David D. Ralph, Noel S. Weiss, and David A. Bluemke

Subjects
0301 basic medicine, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Cardiac fibrosis, Stroke volume, 030204 cardiovascular system & hematology, Histamine h2 receptor antagonist, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Histamine H2 receptor, Apoptosis, Cardiac magnetic resonance imaging, Internal medicine, Heart failure, Ventricular morphology, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Myocardial H2 receptor activation may promote cardiac fibrosis and apoptosis in pre-clinical models and histamine H2 receptor antagonist (H2RA) use may improve symptoms in parti...

Published
2016
Full Text
View/download PDF

2. PLASMA METABOLITE PROFILES ARE ASSOCIATED WITH RIGHT VENTRICULAR DYSFUNCTION AND PROGNOSIS IN PULMONARY ARTERIAL HYPERTENSION

Author

Jonathan Neekon Hourmozdi, Sina A. Gharib, Sam Rayner, Stephanie J. Nolley, Peter J. Leary, and David D. Ralph

Subjects
medicine.medical_specialty, chemistry.chemical_compound, Metabolomics, chemistry, business.industry, Internal medicine, Metabolite, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Prospective cohort study, Right ventricular dysfunction
Abstract

Disease-specific metabolomic signatures have been associated with mortality in pulmonary arterial hypertension (PAH). We explore whether this reflects right ventricular (RV) dysfunction. We analyzed quantitative targeted profiling of over 300 metabolites from a prospective cohort of PAH patients.

Published
2020
Full Text
View/download PDF

3. Reply: Is Histamine H

Author

Peter J, Leary and Michael R, Bristow

Subjects
Histamine H2 Antagonists, Heart Rate, Heart, Receptors, Histamine H2
Published
2016

5. Reply

Author

Michael R. Bristow and Peter J. Leary

Subjects
0301 basic medicine, Drug, business.industry, media_common.quotation_subject, 030204 cardiovascular system & hematology, medicine.disease, Bioinformatics, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Histamine H2 receptor, Heart failure, Immunology, medicine, Cardiology and Cardiovascular Medicine, business, media_common
Abstract

We appreciate the thoughtful review of our work [(1)][1] by Dr. He and colleagues. Although salient, the lack of subgroup analyses by specific H2-receptor antagonists (H2RAs) is a limitation of our work imposed by the data structure and limited number of participants in individual drug subgroups in

Published
2016
Full Text
View/download PDF

6. Reply

Author

Ryan J. Tedford, David D. Ralph, Peter J. Leary, and Richard A. Kronmal

Subjects
0301 basic medicine, business.industry, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, Histamine receptor, 030104 developmental biology, 0302 clinical medicine, chemistry, Histamine H2 receptor, Heart failure, Immunology, medicine, Cardiology and Cardiovascular Medicine, business, Neuroscience, 030217 neurology & neurosurgery, Histamine
Abstract

We appreciate the thoughtful review of our work by Dr. Patane. We unreservedly agree that our observations just scratch the surface regarding histamine and/or histamine receptor activation in heart failure pathogenesis. Our work was intended to explore whether a biologically relevant association

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results