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Start Over Author "Reid, Bruce B" Journal journal of the american college of cardiology
6 results on '"Reid, Bruce B"'

1. Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading

Author

Wever-Pinzon, James, primary, Selzman, Craig H., additional, Stoddard, Greg, additional, Wever-Pinzon, Omar, additional, Catino, Anna, additional, Kfoury, Abdallah G., additional, Diakos, Nikolaos A., additional, Reid, Bruce B., additional, McKellar, Stephen, additional, Bonios, Michael, additional, Koliopoulou, Antigone, additional, Budge, Deborah, additional, Kelkhoff, Aaron, additional, Stehlik, Josef, additional, Fang, James C., additional, and Drakos, Stavros G., additional

Published
2016
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2. Myocardial Atrophy and Chronic Mechanical Unloading of the Failing Human Heart

Author

Diakos, Nikolaos A., primary, Selzman, Craig H., additional, Sachse, Frank B., additional, Stehlik, Josef, additional, Kfoury, Abdallah G., additional, Wever-Pinzon, Omar, additional, Catino, Anna, additional, Alharethi, Rami, additional, Reid, Bruce B., additional, Miller, Dylan V., additional, Salama, Mohamed, additional, Zaitsev, Alexey V., additional, Shibayama, Junko, additional, Li, Hui, additional, Fang, James C., additional, Li, Dean Y., additional, and Drakos, Stavros G., additional

Published
2014
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3. THE RED CELL DISTRIBUTION WIDTH AND THE CBC RISK SCORE MEASURED PRIOR TO LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION PREDICT POST-IMPLANT SURVIVAL

Author

Mannem, Santhosh R., primary, Horne, Benjamin, additional, Saeed, Omar, additional, Kfoury, bdallah, additional, Gunda, Sampath, additional, Salamon, Jason, additional, Budge, Deborah, additional, Bhandari, Manoj, additional, lharethi, Rami, additional, Iqbal, Muhammad, additional, Mazurek, Jeremy, additional, Reid, Bruce B., additional, Goldstein, Daniel, additional, and Zolty, Ronald, additional

Published
2014
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4. Magnitude and Time Course of Changes Induced by Continuous-Flow Left Ventricular Assist Device Unloading in Chronic Heart Failure

Author

Drakos, Stavros G., primary, Wever-Pinzon, Omar, additional, Selzman, Craig H., additional, Gilbert, Edward M., additional, Alharethi, Rami, additional, Reid, Bruce B., additional, Saidi, Abdulfattah, additional, Diakos, Nikolaos A., additional, Stoker, Sandi, additional, Davis, Erin S., additional, Movsesian, Matthew, additional, Li, Dean Y., additional, Stehlik, Josef, additional, and Kfoury, Abdallah G., additional

Published
2013
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5. Impact of Mechanical Unloading on Microvasculature and Associated Central Remodeling Features of the Failing Human Heart

Author

Drakos, Stavros G., primary, Kfoury, Abdallah G., additional, Hammond, Elizabeth H., additional, Reid, Bruce B., additional, Revelo, Monica P., additional, Rasmusson, Brad Y., additional, Whitehead, Kevin J., additional, Salama, Mohamed E., additional, Selzman, Craig H., additional, Stehlik, Josef, additional, Clayson, Stephen E., additional, Bristow, Michael R., additional, Renlund, Dale G., additional, and Li, Dean Y., additional

Published
2010
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6. Myocardial Atrophy and Chronic Mechanical Unloading of the Failing Human Heart Implications for Cardiac Assist Device–Induced Myocardial Recovery

Author

Diakos, Nikolaos A., Selzman, Craig H., Sachse, Frank B., Stehlik, Josef, Kfoury, Abdallah G., Wever-Pinzon, Omar, Catino, Anna, Alharethi, Rami, Reid, Bruce B., Miller, Dylan V., Salama, Mohamed, Zaitsev, Alexey V., Shibayama, Junko, Li, Hui, Fang, James C., Li, Dean Y., and Drakos, Stavros G.

Subjects
mechanical unloading, left ventricular assist device, myocardial atrophy, equipment and supplies
Abstract

BackgroundIn animal models of heterotopic transplantation, mechanical unloading of the normal, nonhypertrophic heart results in atrophy. Primarily on the basis of these animal data, the notion that chronic left ventricular assist device (LVAD)-induced unloading will result in atrophy has dominated the clinical heart failure field, and anti-atrophic drugs have been used to enhance the cardiac recovery potential observed in some LVAD patients. However, whether unloading-induced atrophy in experimental normal heart models applies to failing and hypertrophic myocardium in heart failure patients unloaded by continuous-flow LVADs has not been studied.ObjectivesThe study examined whether mechanical unloading by continuous-flow LVAD leads to myocardial atrophy.MethodsWe prospectively examined myocardial tissue and hemodynamic and echocardiographic data from 44 LVAD patients and 18 untransplanted normal donors.ResultsCardiomyocyte size (cross-sectional area) decreased after LVAD unloading from 1,238 ± 81 μm2 to 1,011 ± 68 μm2 (p = 0.001), but not beyond that of normal donor hearts (682 ± 56 μm2). Electron microscopy ultrastructural evaluation, cardiomyocyte glycogen content, and echocardiographic assessment of myocardial mass and left ventricular function also did not suggest myocardial atrophy. Consistent with these findings, t-tubule morphology, cytoplasmic penetration, and distance from the ryanodine receptor were not indicative of ongoing atrophic remodeling during LVAD unloading. Molecular analysis revealed no up-regulation of proatrophic genes and proteins of the ubiquitin proteasome system.ConclusionsStructural, ultrastructural, microstructural, metabolic, molecular, and clinical functional data indicated that prolonged continuous-flow LVAD unloading does not induce hypertrophy regression to the point of atrophy and degeneration. These findings may be useful in designing future investigations that combine LVAD unloading and pharmaceutical therapies as a bridge to recovery of the failing heart.

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