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Start Over Author "Khan, Muhammad" Journal journal of the american college of cardiology (jacc)
164 results on '"Khan, Muhammad"'

1. Implementing Guideline-Directed Medical Therapy for Heart Failure: JACC Focus Seminar 1/3.

Author

Patolia, Harsh, Khan, Muhammad Shahzeb, Fonarow, Gregg C., Butler, Javed, and Greene, Stephen J.

Subjects
*HEART failure, *VENTRICULAR ejection fraction, *CAUSES of death, *VASOMOTOR conditioning, *CLINICAL medicine
Abstract

Despite the availability of lifesaving guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), there remain major gaps in utilization of these therapies among eligible patients. Simultaneous with these gaps in quality of care, HFrEF continues as a leading cause of death and hospitalization with associated clinical risk far exceeding most other cardiovascular and noncardiovascular conditions. In the context of this urgent need to improve provision of appropriate therapy, multiple lines of evidence support various implementation strategies. Such strategies include in-hospital initiation of GDMT, simultaneous or rapid sequence initiation of GDMT, participation in quality improvement registries to assess site performance and provide feedback, multidisciplinary titration clinics, virtual consult teams, reduction of cost-sharing, remote algorithm-based medication optimization, electronic health record-based interventions, and direct-to-patient educational initiatives. This review describes and contextualizes the evidence surrounding each of these potential avenues for improving use of foundational GDMTs for patients with HFrEF. [Display omitted] • There are wide gaps in use of guideline-recommended medications for patients with HFrEF. • Several strategies are available to improve utilization of GDMT for HFrEF. • Wider adoption of these strategies could enhance quality of care and clinical outcomes for a large number of patients. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Albuminuria and Heart Failure: JACC State-of-the-Art Review.

Author

Khan, Muhammad Shahzeb, Shahid, Izza, Anker, Stefan D., Fonarow, Gregg C., Fudim, Marat, Hall, Michael E., Hernandez, Adrian, Morris, Alanna A., Shafi, Tariq, Weir, Matthew R., Zannad, Faiez, Bakris, George L., and Butler, Javed

Subjects
*HEART failure, *ALBUMINURIA, *GLOMERULAR filtration rate, *CHRONIC kidney failure, *HEART failure patients
Abstract

Although chronic kidney disease is characterized by low glomerular filtration rate (GFR) or albuminuria, estimated GFR (eGFR) is more widely utilized as a marker of risk profile in cardiovascular diseases, including heart failure (HF). The presence and magnitude of albuminuria confers a strong prognostic association in forecasting risk of incident HF as well as its progression, irrespective of eGFR. Despite the high prevalence of albuminuria in HF, whether it adds incremental prognostic information in clinical practice and serves as an independent risk marker, and whether there are any therapeutic implications of assessing albuminuria in patients with HF is less well-established. In this narrative review, we assess the potential role of albuminuria in risk profiling for development and progression of HF, strengths and limitations of utilizing albuminuria as a risk marker, its ability to serve in HF risk prediction models, and the implications of adopting albuminuria as an effective parameter in cardiovascular trials and practice. [Display omitted] • Albuminuria is prevalent in patients with heart failure and confers a strong, consistent and independent association with risk. • The causes of albuminuria in patients with heart failure are incompletely understood, as are the mechanisms linking it to disease progression and adverse outcomes. • Interventions that reduce albuminuria may potentially lower the risk of incident heart failure or prevent progression of existing heart failure. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Prevalence and Prognostic Implications of Diabetes With Cardiomyopathy in Community-Dwelling Adults.

Author

Segar, Matthew W., Khan, Muhammad Shahzeb, Patel, Kershaw V., Butler, Javed, Tang, W.H. Wilson, Vaduganathan, Muthiah, Lam, Carolyn S.P., Verma, Subodh, McGuire, Darren K., and Pandey, Ambarish

Subjects
*PROGNOSIS, *CARDIOVASCULAR diseases, *CHRONIC kidney failure, *CARDIOMYOPATHIES, *HEART failure, *BLOOD sugar analysis, *GLOMERULAR filtration rate, *BIOLOGICAL models, *RESEARCH, *DIABETIC cardiomyopathy, *AGE distribution, *RESEARCH methodology, *MEDICAL cooperation, *EVALUATION research, *TYPE 2 diabetes, *COMPARATIVE studies, *DISEASE prevalence, *BODY mass index, *LONGITUDINAL method
Abstract

Background: Diabetes is associated with abnormalities in cardiac remodeling and high risk of heart failure (HF).Objectives: The purpose of this study was to evaluate the prevalence and prognostic implications of diabetes with cardiomyopathy (DbCM) among community-dwelling individuals.Methods: Adults without prevalent cardiovascular disease or HF were pooled from 3 cohort studies (ARIC [Atherosclerosis Risk In Communities], CHS [Cardiovascular Health Study], CRIC [Chronic Renal Insufficiency Cohort]). Among participants with diabetes, DbCM was defined using different definitions: 1) least restrictive: ≥1 echocardiographic abnormality (left atrial enlargement, left ventricle hypertrophy, diastolic dysfunction); 2) intermediate restrictive: ≥2 echocardiographic abnormalities; and 3) most restrictive: elevated N-terminal pro-B-type natriuretic peptide levels (>125 in normal/overweight or >100 pg/mL in obese) plus ≥2 echocardiographic abnormalities. Adjusted Fine-Gray models were used to evaluate the risk of HF.Results: Among individuals with diabetes (2,900 of 10,208 included), the prevalence of DbCM ranged from 67.0% to 11.7% in the least and most restrictive criteria, respectively. Higher fasting glucose, body mass index, and age as well as worse kidney function were associated with higher risk of DbCM. The 5-year incidence of HF among participants with DbCM ranged from 8.4%-12.8% in the least and most restrictive definitions, respectively. Compared with euglycemia, DbCM was significantly associated with higher risk of incident HF with the highest risk observed for the most restrictive definition of DbCM (HR: 2.55 [95% CI: 1.69-3.86]; least restrictive criteria HR: 1.99 [95% CI: 1.50-2.65]). A similar pattern of results was observed across cohort studies, across sex and race subgroups, and among participants without hypertension or obesity.Conclusions: Regardless of the criteria used to define cardiomyopathy, DbCM identifies a high-risk subgroup for developing HF. [ABSTRACT FROM AUTHOR]

Published
2021
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13. TCT-172 National Readmissions Data-Based Analysis of Comorbidities and Mortality With Sex-Specific Mortality of Transcutaneous Versus Open Surgical Tricuspid Valve Interventions.

Author

Baqi, Abdul, Khan, Muhammad, Ghumman, Ghulam Mujtaba, Ullah, Waqas, Shah, Jay, Tahir, Ayesha, Sattar, Yasar, Mir, Tanveer, Sheikh, Zain, Salman, F.N.U., Baghal, Moaaz, Luthra, Kritika, Shoaib, Farwa, Waqar, Zainulabedin, Taleb, Mohammed, and Ali, Syed

Subjects
*TRICUSPID valve, *TRICUSPID valve surgery, *PATIENT readmissions, *MORTALITY
Published
2023
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16. TCT-171 National Estimates for Percentage of All Readmissions With Demographic Features, Length of Stay, and Cost Analysis of Transcutaneous Versus Open Surgical Tricuspid Valve Interventions.

Author

Khan, Muhammad, Baqi, Abdul, Ghumman, Ghulam Mujtaba, Tahir, Ayesha, Ullah, Waqas, Shah, Jay, Sattar, Yasar, Mir, Tanveer, Sheikh, Zain, Salman, F.N.U., Baghal, Moaaz, Luthra, Kritika, Waqar, Zainulabedin, Shoaib, Farwa, Taleb, Mohammed, and Ali, Syed

Subjects
*TRICUSPID valve, *COST analysis, *PATIENT readmissions, *TRICUSPID valve surgery, *PERCENTILES
Published
2023
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17. TCT-219 Same-Day Discharge After Transcatheter Aortic Valve Implantation: Insights From the National Readmissions Database for 2016-2018.

Author

Zahid, Salman, Khan, Muhammad, Ullah, Waqas, Rai, Devesh, Ud Din, Mian Tanveer, Abbas, Sakina, Ubaid, Aamer, Thakkar, Sammarthkumar, Salman, Fnu, Khan, Muhammad Atif, Salama, Amr, Alkhouli, Mohamad, Balla, Sudarshan, and Depta, Jeremiah

Subjects
*HEART valve prosthesis implantation, *PATIENT readmissions, *DATABASES
Published
2021
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18. TCT-127 Medical Therapy Versus Early Revascularization in Diabetics With Chronic Total Occlusion of Coronary Arteries: A Meta-analysis and Systematic Review.

Author

Wazir, Abdul, Khan, Muhammad, Sami, Farhad, Salman, F.N.U., Khattak, Furqan, Shah, Jay, Shafqat, Madeeha, Khan, Amir, Adil, Abid, Sana, Maryam, Ahsan, Muhammad, Ghumman, Ghulam Mujtaba, Singh, Hemindermeet, Taleb, Mohammed, and Ali, Syed

Subjects
*CHRONIC total occlusion, *CORONARY occlusion, *PEOPLE with diabetes
Published
2022
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38. TRENDS AND EXIT STRATEGIES OF VENO ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION (VA-ECMO) IN CARDIOGENIC SHOCK PATIENTS : REPORT FORM NATIONAL INPATIENT SAMPLE.

Author

Syed, Moinuddin and Khan, Muhammad

Subjects
*EXTRACORPOREAL membrane oxygenation, *CARDIOGENIC shock
Abstract

TRENDS AND EXIT STRATEGIES OF VENO ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION (VA-ECMO) IN CARDIOGENIC SHOCK PATIENTS: REPORT FORM NATIONAL INPATIENT SAMPLE. [Extracted from the article]

Published
2021
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44. TRENDS AND EXIT STRATEGIES OF VENO ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION (VA-ECMO) IN CARDIOGENIC SHOCK PATIENTS : REPORT FORM NATIONAL INPATIENT SAMPLE.

Author

Syed, Moinuddin and Khan, Muhammad

Subjects
*EXTRACORPOREAL membrane oxygenation, *CARDIOGENIC shock
Abstract

TRENDS AND EXIT STRATEGIES OF VENO ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION (VA-ECMO) IN CARDIOGENIC SHOCK PATIENTS: REPORT FORM NATIONAL INPATIENT SAMPLE. [Extracted from the article]

Published
2021
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