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Your search keyword '"Saad, Marwan"' showing total 42 results
Start Over Author "Saad, Marwan" Journal journal of the american college of cardiology (jacc)
42 results on '"Saad, Marwan"'

1. Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Rheumatic Aortic Stenosis.

Author

Mentias, Amgad, Saad, Marwan, Desai, Milind Y., Krishnaswamy, Amar, Menon, Venu, Horwitz, Phillip A., Kapadia, Samir, and Sarrazin, Mary Vaughan

Subjects
*AORTIC valve transplantation, *AORTIC stenosis, *NOSOLOGY, *HEART valve prosthesis implantation
Abstract

Background: Patients with rheumatic aortic stenosis (AS) were excluded from transcatheter aortic valve replacement (TAVR) trials.Objectives: The authors sought to examine outcomes with TAVR versus surgical aortic valve replacement (SAVR) in patients with rheumatic AS, and versus TAVR in nonrheumatic AS.Methods: The authors identified Medicare beneficiaries who underwent TAVR or SAVR from October 2015 to December 2017, and then identified patients with rheumatic AS using prior validated International Classification of Diseases, Version 10 codes. Overlap propensity score weighting analysis was used to adjust for measured confounders. The primary study outcome was all-cause mortality. Multiple secondary outcomes were also examined.Results: The final study cohort included 1,159 patients with rheumatic AS who underwent aortic valve replacement (SAVR, n = 554; TAVR, n = 605), and 88,554 patients with nonrheumatic AS who underwent TAVR. Patients in the SAVR group were younger and with lower prevalence of most comorbidities and frailty scores. After median follow-up of 19 months (interquartile range: 13 to 26 months), there was no difference in all-cause mortality with TAVR versus SAVR (11.2 vs. 7.0 per 100 person-year; adjusted hazard ratio: 1.53; 95% confidence interval: 0.84 to 2.79; p = 0.2). Compared with TAVR in nonrheumatic AS, TAVR for rheumatic AS was associated with similar mortality (15.2 vs. 17.7 deaths per 100 person-years (adjusted hazard ratio: 0.87; 95% confidence interval: 0.68 to 1.09; p = 0.2) after median follow-up of 17 months (interquartile range: 11 to 24 months). None of the rheumatic TAVR patients, <11 SAVR patients, and 242 nonrheumatic TAVR patients underwent repeat aortic valve replacement (124 redo-TAVR and 118 SAVR) at follow-up.Conclusions: Compared with SAVR, TAVR could represent a viable and possibly durable option for patients with rheumatic AS. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Aspirin for Primary Prevention of Cardiovascular Events.

Author

Abdelaziz, Hesham K, Saad, Marwan, Pothineni, Naga Venkata K, Megaly, Michael, Potluri, Rahul, Saleh, Mohammed, Kon, David Lai Chin, Roberts, David H, Bhatt, Deepak L, Aronow, Herbert D, Abbott, J Dawn, and Mehta, Jawahar L

Subjects
*CARDIOVASCULAR disease prevention, *GASTROINTESTINAL hemorrhage diagnosis, *CARDIOVASCULAR disease diagnosis, *CLINICAL trials, *META-analysis, *GASTROINTESTINAL hemorrhage, *NONSTEROIDAL anti-inflammatory agents, *SYSTEMATIC reviews, *PREVENTIVE health services, *ASPIRIN, CARDIOVASCULAR disease related mortality
Abstract

Background: The efficacy and safety of aspirin for primary prevention of cardiovascular disease (CVD) remain debatable.Objectives: The purpose of this study was to examine the clinical outcomes with aspirin for primary prevention of CVD after the recent publication of large trials adding >45,000 individuals to the published data.Methods: Randomized controlled trials comparing clinical outcomes with aspirin versus control for primary prevention with follow-up duration of ≥1 year were included. Efficacy outcomes included all-cause death, cardiovascular (CV) death, myocardial infarction (MI), stroke, transient ischemic attack (TIA), and major adverse cardiovascular events. Safety outcomes included major bleeding, intracranial bleeding, fatal bleeding, and major gastrointestinal (GI) bleeding. Random effects DerSimonian-Laird risk ratios (RRs) for outcomes were calculated.Results: A total of 15 randomized controlled trials including 165,502 participants (aspirin n = 83,529, control n = 81,973) were available for analysis. Compared with control, aspirin was associated with similar all-cause death (RR: 0.97; 95% confidence interval [CI]: 0.93 to 1.01), CV death (RR: 0.93; 95% CI: 0.86 to 1.00), and non-CV death (RR: 0.98; 95% CI: 0.92 to 1.05), but a lower risk of nonfatal MI (RR: 0.82; 95% CI: 0.72 to 0.94), TIA (RR: 0.79; 95% CI: 0.71 to 0.89), and ischemic stroke (RR: 0.87; 95% CI: 0.79 to 0.95). Aspirin was associated with a higher risk of major bleeding (RR: 1.5; 95% CI: 1.33 to 1.69), intracranial bleeding (RR: 1.32; 95% CI: 1.12 to 1.55), and major GI bleeding (RR: 1.52; 95% CI: 1.34 to 1.73), with similar rates of fatal bleeding (RR: 1.09; 95% CI: 0.78 to 1.55) compared with the control subjects. Total cancer and cancer-related deaths were similar in both groups within the follow-up period of the study.Conclusions: Aspirin for primary prevention reduces nonfatal ischemic events but significantly increases nonfatal bleeding events. [ABSTRACT FROM AUTHOR]

Published
2019
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3. Preoperative Atrial Fibrillation and Cardiovascular Outcomes After Noncardiac Surgery.

Author

Prasada, Sameer, Desai, Milind Y., Saad, Marwan, Smilowitz, Nathaniel R., Faulx, Michael, Menon, Venu, Moudgil, Rohit, Chaudhury, Pulkit, Hussein, Ayman A., Taigen, Tyler, Nakhla, Shady, and Mentias, Amgad

Subjects
*ATRIAL fibrillation, *CARDIOVASCULAR surgery, *PROPENSITY score matching, *MYOCARDIAL infarction, *MYOCARDIAL infarction complications, *STROKE, *RISK assessment, *HEART failure, *MEDICARE, *DISEASE complications
Abstract

Background: The impact of pre-existing atrial fibrillation (AF) on outcomes after noncardiac surgery is not clear.Objectives: We aimed to study the impact of AF on the risk of adverse outcomes after noncardiac surgery in a nationwide cohort.Methods: We identified Medicare beneficiaries admitted for noncardiac surgery from 2015 to 2019 and divided the study cohort into 2 groups: with and without AF. Noncardiac surgery was classified into vascular, thoracic, general, genitourinary, gynecological, orthopedics and neurosurgery, breast, head and neck, and transplant. We used propensity score matching on exact age, sex, race, urgency and type of surgery, revised cardiac risk index (RCRI) and CHA2DS2-VASc score, and tight caliper on other comorbidities. The study outcomes were 30-day mortality, stroke, myocardial infarction, and heart failure. We examined the incremental utility of AF in addition to RCRI to predict adverse events after noncardiac surgery.Results: The study cohort included 8,635,758 patients who underwent noncardiac surgery (16.4% with AF). Patients with AF were older, more likely to be men, and had higher prevalence of comorbidities. After propensity score matching, AF was associated with higher risk of mortality (OR: 1.31; 95% CI: 1.30-1.32), heart failure (OR: 1.31; 95% CI: 1.30-1.33), and stroke (OR: 1.40; 95% CI: 1.37-1.43) and lower risk of myocardial infarction (OR: 0.81; 95% CI: 0.79-0.82). Results were consistent in subgroup analysis by sex, race, type of surgery, and all strata of RCRI and CHA2DS2-VASc score. AF improved the discriminative ability of RCRI (C-statistic 0.73 to 0.76).Conclusion: Pre-existing AF is independently associated with postoperative adverse outcomes after NCS. [ABSTRACT FROM AUTHOR]

Published
2022
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7. TCT-522 Long-Term Outcomes with Saphenous Vein Graft versus Native Coronary Artery Intervention in Patients with Coronary Artery Bypass Grafting: Evidence From Meta-analysis and Meta-regression.

Author

Saad, Marwan, Nairooz, Ramez, Elbadawi, Ayman, Habash, Fuad, Abbott, J. Dawn, Kleiman, Neal, Brilakis, Emmanouil, Dhillon, Ashwat, Awar, Lena, Clavijo, Leonardo, Matthews, Ray, and Shavelle, David

Subjects
*SAPHENOUS vein, *CORONARY arteries, *CORONARY artery bypass
Published
2018
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13. HEAVY HEART WITH LIGHT PROTEINS: AN INSIGHT.

Author

Abuzaid, Ahmed Sami, Saad, Marwan, Ayan, Mohamed, Smer, Aiman, and Arouni, Amy

Subjects
*HEART failure, *ARRHYTHMIA diagnosis, *EXERCISE physiology, *ECHOCARDIOGRAPHY, *PERIODIC health examinations, *BLOOD pressure, *HYPERTENSION, *DYSLIPIDEMIA, *HISTORY of medicine
Published
2015
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25. TCT-99 Outcomes With Retrograde Versus Antegrade Chronic Total Occlusion Revascularization.

Author

Megaly, Michael, Ali, Abdelrahman, Saad, Marwan, Omer, Mohamed, Xenogiannis, Iosif, Werner, Gerald, Karmpaliotis, Dimitrios, Russo, Juan, Yamane, Masahisa, Garbo, Roberto, Ungi, Imre, Rinfret, Stéphane, Pershad, Ashish, Garcia, Santiago, Sianos, Georgios, Mashayekhi, Kambis, Galassi, Alfredo, Burke, M. Nicholas, and Brilakis, Emmanouil

Subjects
*CEREBRAL revascularization, *PERCUTANEOUS coronary intervention
Published
2019
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31. TCT-7 Invasive Versus Conservative Strategy in Elderly Patients With Non–ST-Segment Elevation Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials.

Author

Khalil, Mahmoud, Maqsood, Muhammad Haisum, Basir, Mir, Saad, Marwan, Yassa, George, Hakam, Laila, Hennawy, Bassam, El Etriby, Shehab, Garcia, Santiago, Brilakis, Emmanouil, Alaswad, Khaldoon, and Megaly, Michael

Subjects
*MYOCARDIAL infarction, *OLDER patients, *RANDOMIZED controlled trials, *CONSERVATIVES
Published
2022
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39. EFFECT OF TRANSCATHETER AORTIC VALVE REPLACEMENT ON EARLY CORONARY HEMODYNAMICS IN PATIENTS WITH SEVERE AORTIC STENOSIS AND CONCOMITANT CORONARY ARTERY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Author

Khan, Mohammad Saud, Khan, Abdur Rahman, Moustafa, Abdelmoniem, Pavlech, Laura, Hyder, Omar, Soukas, Peter, Saad, Marwan, and Aronow, Herbert

Subjects
*HEART valve prosthesis implantation, *CORONARY artery stenosis, *AORTIC stenosis, *CORONARY disease, *HEMODYNAMICS
Published
2021
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40. EFFECT OF TRANSCATHETER AORTIC VALVE REPLACEMENT ON EARLY CORONARY HEMODYNAMICS IN PATIENTS WITH SEVERE AORTIC STENOSIS AND CONCOMITANT CORONARY ARTERY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Author

Khan, Mohammad Saud, Khan, Abdur Rahman, Moustafa, Abdelmoniem, Pavlech, Laura, Hyder, Omar, Soukas, Peter, Saad, Marwan, and Aronow, Herbert

Subjects
*HEART valve prosthesis implantation, *CORONARY artery stenosis, *AORTIC stenosis, *CORONARY disease, *HEMODYNAMICS, *AORTIC valve insufficiency
Published
2021
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41. OUTCOMES OF CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY.

Author

Megaly, Michael, Abraham, Bishoy, Omer, Mohamed, Elbadawi, Ayman, Saad, Marwan, Mentias, Amgad, Xenogiannis, Iosif, Narayanan, Mahesh Anantha, Banerjee, Subhash, Alaswad, Khaldoon, Rinfret, Stéphane, Garcia, Santiago, Pershad, Ashish, Azzalini, Lorenzo, Knaapen, Paul, Tsuchikane, Etsuo, Gershlick, Anthony, Burke, M. Nicholas, and Brilakis, Emmanouil

Subjects
*CORONARY artery bypass, *PERCUTANEOUS coronary intervention, *TRANSPLANTATION of organs, tissues, etc.
Published
2020
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