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Your search keyword '"Szymonifka, Jackie"' showing total 14 results
Start Over Author "Szymonifka, Jackie" Journal journal of the american college of cardiology (jacc)
14 results on '"Szymonifka, Jackie"'

3. Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays.

Author

Ibrahim, Nasrien E., McCarthy, Cian P., Shrestha, Shreya, Gaggin, Hanna K., Mukai, Renata, Szymonifka, Jackie, Apple, Fred S., Burnett, John C., Iyer, Seethalakshmi, Januzzi, James L., Burnett, John C Jr, and Januzzi, James L Jr

Subjects
*BRAIN natriuretic factor, *NEPRILYSIN, *NATRIURETIC peptides, *HEART failure patients
Abstract

Background: With sacubitril/valsartan treatment, B-type natriuretic peptide (BNP) concentrations increase; it remains unclear whether change in BNP concentrations is similar across all assays for its measurement. Effects of sacubitril/valsartan on atrial natriuretic peptide (ANP) concentrations in patients are unknown. Lastly, the impact of neprilysin inhibition on mid-regional pro-ANP (MR-proANP), N-terminal pro-BNP (NT-proBNP), proBNP1-108, or C-type natriuretic peptide (CNP) is not well understood.Objectives: This study sought to examine the effects of sacubitril/valsartan on results from different natriuretic peptide assays.Methods: Twenty-three consecutive stable patients with heart failure and reduced ejection fraction were initiated and titrated on sacubitril/valsartan. Change in ANP, MR-proANP, BNP (using 5 assays), NT-proBNP (3 assays), proBNP1-108, and CNP were measured over 3 visits.Results: Average time to 3 follow-up visits was 22, 46, and 84 days. ANP rapidly and substantially increased with initiation and titration of sacubitril/valsartan, more than doubling by the first follow-up visit (+105.8%). Magnitude of ANP increase was greatest in those with concentrations above the median at baseline (+188%) compared with those with lower baseline concentrations (+44%); ANP increases were sustained. Treatment with sacubitril/valsartan led to inconsistent changes in BNP, which varied across methods assessed. Concentrations of MR-proANP, NT-proBNP, and proBNP1-108 variably declined after treatment; whereas CNP concentrations showed no consistent change.Conclusions: Initiation and titration of sacubitril/valsartan led to variable changes in concentrations of multiple natriuretic peptides. These results provide important insights into the effects of sacubitril/valsartan treatment on individual patient results, and further suggest the benefit of neprilysin inhibition may be partially mediated by increased ANP concentrations. [ABSTRACT FROM AUTHOR]

Published
2019
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12. A SIMPLE-TO-USE NOMOGRAM FOR PREDICTING 5-, 10- AND 15-YEAR SURVIVAL FOR ASYMPTOMATIC INDIVIDUALS UNDERGOING CORONARY ARTERY CALCIUM SCORING.

Author

Hartaigh, Briain O, Gransar, Heidi, Callister, Tracy, Shaw, Leslee, Schulman-Marcus, Joshua, Valenti, Valentina, Cho, Iksung, Truong, Quynh, Szymonifka, Jackie, and Min, James

Subjects
*CORONARY disease, *CALCIUM in the body, *CARDIOVASCULAR diseases risk factors, *CAUSES of death, *PROPORTIONAL hazards models
Published
2015
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13. DIAGNOSIS OF NECROTIC INTRAPLAQUE CORES BY DUAL ENERGY CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY IN VICTIMS OF SUDDEN CORONARY DEATH: VALIDATION TO A PATHOLOGIC GOLD STANDARD.

Author

Elmore, Kimberly, Cho, Iksung, Hartaigh, Briain O, Schulman-Marcus, Joshua, Szymonifka, Jackie, Earls, James, Yahagi, Kazuyuki, Xiong, Guanglei, Starikov, Anna, Joner, Michael, Virmani, Renu, and Min, James

Subjects
*CORONARY disease, *PLAQUEMINE culture, *ANGIOGRAPHY, *COMPUTED tomography, *SUDDEN death
Published
2015
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