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Start Over Author "Tay, Edgar" Journal journal of the american college of cardiology (jacc)
36 results on '"Tay, Edgar"'

8. Impact of Left Ventricular Ejection Fraction on Clinical Outcomes in Bicuspid Aortic Valve Disease.

Author

Hecht, Sébastien, Butcher, Steele C., Pio, Stephan M., Kong, William K.F., Singh, Gurpreet K., Ng, Arnold C.T., Perry, Rebecca, Poh, Kian Keong, Almeida, Ana G., González, Ariana, Shen, Mylène, Yeo, Tiong Cheng, Shanks, Miriam, Popescu, Bogdan A., Gay, Laura Galian, Fijałkowski, Marcin, Liang, Michael, Tay, Edgar, Marsan, Nina Ajmone, and Selvanayagam, Joseph

Subjects
*AORTIC valve diseases, *MITRAL valve, *VENTRICULAR ejection fraction, *AORTIC valve, *TREATMENT effectiveness, *AORTIC valve insufficiency, *HEART failure
Abstract

Background: The prognostic impact of left ventricular ejection fraction (LVEF) in patients with bicuspid aortic valve (BAV) disease has not been previously studied.Objectives: The purpose of this study was to determine the prognostic impact of LVEF in BAV patients according to the type of aortic valve dysfunction.Methods: We retrospectively analyzed the data collected in 2,672 patients included in an international registry of patients with BAV. Patients were classified according to the type of aortic valve dysfunction: isolated aortic stenosis (AS) (n = 749), isolated aortic regurgitation (AR) (n = 554), mixed aortic valve disease (MAVD) (n = 190), or no significant aortic valve dysfunction (n = 1,179; excluded from this analysis). The study population was divided according to LVEF strata to investigate its impact on clinical outcomes.Results: The risk of all-cause mortality and the composite endpoint of aortic valve replacement or repair (AVR) and all-cause mortality increased when LVEF was <60% in the whole cohort as well as in the AS and AR groups, and when LVEF was <55% in MAVD group. In multivariable analysis, LVEF strata were significantly associated with increased rate of mortality (LVEF 50%-59%: HR: 1.83 [95% CI: 1.09-3.07]; P = 0.022; LVEF 30%-49%: HR: 1.97 [95% CI: 1.13-3.41]; P = 0.016; LVEF <30%: HR: 4.20 [95% CI: 2.01-8.75]; P < 0.001; vs LVEF 60%-70%, reference group).Conclusions: In BAV patients, the risk of adverse clinical outcomes increases significantly when the LVEF is <60%. These findings suggest that LVEF cutoff values proposed in the guidelines to indicate intervention should be raised from 50% to 60% in AS or AR and 55% in MAVD. [ABSTRACT FROM AUTHOR]

Published
2022
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9. ASSOCIATION OF LEFT VENTRICULAR DILATATION PATTERNS WITH MORTALITY IN PATIENTS WITH MODERATE AND MODERATE-SEVERE AORTIC REGURGITATION.

Author

Santi, María Pilar López, Bernard, Jérémy, Butcher, Steele, Meucci, Maria Chiara, Sarrazyn, Camille, Laenens, Dorien, Chua, Aileen Paula A., Myagmardorj, Rinchyenkhand, Nabeta, Takeru, Fortuni, Federico, Popescu, Bogdan Alexandru, Tay, Edgar, Yiu, Kai Hang, Pibarot, Philippe, Bax, Jeroen J., and Marsan, Nina Ajmone

Subjects
*AORTIC valve insufficiency, *MORTALITY
Published
2024
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11. SAFETY AND EFFICACY OF THE COMBINATION SIROLIMUS-ELUTING ENDOTHELIAL PROGENITOR CELL CAPTURE STENT IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION: ONE YEAR FOLLOW-UP.

Author

Yun Loh, Joshua Ping, Carvalho, Leonardo, Tay, Edgar, Lee, Chi-Hang, Chan, Koo, Chan, Mark, Low, Adrian, Loh, Poay Huan, and Tan, Huay-Cheem

Subjects
*RAPAMYCIN, *MYOCARDIAL infarction treatment, *ENDOTHELIAL cells, *PROGENITOR cells, *FOLLOW-up studies (Medicine), *SURGICAL stents
Published
2016
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12. Transcatheter Aortic Valve Replacement With Early- and New-Generation Devices in Bicuspid Aortic Valve Stenosis.

Author

Yoon, Sung-Han, Lefèvre, Thierry, Ahn, Jung-Ming, Perlman, Gidon Y., Dvir, Danny, Latib, Azeem, Barbanti, Marco, Deuschl, Florian, De Backer, Ole, Blanke, Philipp, Modine, Thomas, Pache, Gregor, Neumann, Franz-Josef, Ruile, Philipp, Arai, Takahide, Ohno, Yohei, Kaneko, Hidehiro, Tay, Edgar, Schofer, Niklas, and Holy, Erik W.

Subjects
*ARTERIAL stenosis treatment, *ARTERIAL stenosis, *AORTIC valve transplantation, *BICUSPIDS, *HEALTH outcome assessment, *PATIENTS, *SURGERY, *AORTIC valve abnormalities, *PROSTHETIC heart valves, *AORTIC stenosis, *COMPARATIVE studies, *HEART valve diseases, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *PRODUCT design, *EVALUATION research, *DISEASE complications, *EQUIPMENT & supplies, AORTIC valve surgery
Abstract

Background: Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS). Particularly, limited data exist comparing the results of TAVR with new-generation devices versus early-generation devices.Objectives: This study sought to evaluate the clinical outcomes of TAVR for bicuspid AS with early- and new-generation devices.Methods: The Bicuspid TAVR Registry is an international multicenter study enrolling consecutive patients with bicuspid AS undergoing TAVR between April 2005 and May 2015.Results: Of 301 patients, 199 patients (71.1%) were treated with early-generation devices (Sapien XT [Edwards Lifesciences Corporation, Irvine, California]: n = 87; CoreValve [Medtronic, Minneapolis, Minnesota]: n = 112) and 102 with new-generation devices (Sapien 3 [Edwards Lifesciences Corporation]: n = 91; Lotus [Boston Scientific Corporation, Marlborough, Massachusetts]: n = 11). The mean Society of Thoracic Surgeons score was 4.7 ± 5.2 without significant differences between groups (4.6 ± 5.1 vs. 4.9 ± 5.4; p = 0.57). Overall, all-cause mortality rates were 4.3% at 30 days and 14.4% at 1 year. Moderate or severe paravalvular leak was absent and significantly less frequent with new-generation compared to early-generation devices (0.0% vs. 8.5%; p = 0.002), which resulted in a higher device success rate (92.2% vs. 80.9%; p = 0.01). There were no differences between early- and new-generation devices in stroke (2.5% vs. 2.0%; p > 0.99), life-threatening bleeding (3.5% vs. 2.9%; p > 0.99), major vascular complication (4.5% vs. 2.9%; p = 0.76), stage 2 to 3 acute kidney injury (2.5% vs. 2.9%; p > 0.99), early safety endpoints (15.1% vs. 10.8%; p = 0.30), and 30-day all-cause mortality (4.5% vs. 3.9%; p > 0.99).Conclusions: The clinical outcomes of TAVR in patients with bicuspid AS were favorable. New-generation devices were associated with less paravalvular leak and, hence, a higher device success rate than early-generation devices. (The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry [Bicuspid TAVR]; NCT02394184). [ABSTRACT FROM AUTHOR]

Published
2016
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19. ETHNIC DIFFERENCES IN COMPUTED TOMOGRAPHY AORTIC VALVE CALCIUM QUANTIFICATION IN PATIENTS WITH AORTIC STENOSIS.

Author

Guzzetti, Ezequiel, Oh, Jin Kyung, Shen, Mylène, Dweck, Marc, Poh, Kian Keong, Abbas, Amr E., Mando, Ramy, Pressman, Gregg S., Brito, Daniel, Tastet, Lionel Lloyd, Pawade, Tania, Falconi, Mariano, de Arenaza, Diego Perez, Kong, William, Tay, Edgar, Pibarot, Philippe, Song, Jae-Kwan, and Clavel, Marie-Annick

Subjects
*ETHNIC differences, *AORTIC valve, *AORTIC stenosis, *ASIANS, *CALCIUM
Published
2020
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22. TCT-305 Real-World Experience of Biodegradable-Polymer Drug Eluting Stents Versus Second-Generation Durable-Polymer Drug-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Author

Sim, Hui Wen, Thong, Elizabeth H.E., Ser, Joon Sin, Chen, Jason Zhenfeng, Chan, Mark, Lee, Ronald, Tan, Huay Cheem, Low, Adrian, Tay, Edgar, Loh, Poay Huan, Chan, Koo Hui, and Loh, Joshua

Subjects
*DRUG-eluting stents, *PERCUTANEOUS coronary intervention, *MYOCARDIAL infarction, *CARDIOGENIC shock, *INTRA-aortic balloon counterpulsation
Published
2019
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31. TCT-104 Clinical Outcomes of Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis.

Author

Yoon, Sung-Han, Lefevre, Thierry, Dvir, Danny, Ahn, Jung-Min, Arai, Takahide, Kim, Young-Hak, Watanabe, Yusuke, Hsien-Li Kao, Paul, Yong, Gerald, Yin, Wei-Hsian, Kang-Yin Lee, Michael, Tay, Edgar L., Kim, Hyo-Soo, Chevalier, Bernard, Morice, Marie-Claude, John, Webb, and Park, Seung-Jung

Subjects
*MITRAL stenosis, *ARTERIAL catheters, *ECHOCARDIOGRAPHY, *MEDICAL research, *MEDICAL centers, *THERAPEUTICS, AORTIC valve surgery
Published
2015
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32. TCT-92 Transcatheter Aortic Valve Replacement in Asian Pacific Countries.

Author

Yoon, Sung-Han, Ahn, Jung-Min, Araki, Motoharu, Yamanaka, Futoshi, Lin, Mao-Shin, Chan, Jason Leung Kwai, Tay, Edgar L., Lee, Yung Tsai, Inohara, Taku, Yanagisawa, Ryo, Park, Jun-Bean, Watanabe, Yusuke, Shirai, Shinichi, Lee, Michael K., Kao, Paul Hsien-Li, Yin, Wei-Hsian, Yong, Gerald, Hayashida, Kentaro, Muramatsu, Toshiya, and Kim, Hyo-Soo

Subjects
*AORTIC stenosis treatment, *IMPLANTABLE catheters, *ECHOCARDIOGRAPHY, *MEDICAL registries, *MEDICAL centers, AORTIC valve surgery
Published
2015
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