1. Evaluation of patients labeled with a penicillin allergy to promote antimicrobial stewardship in dental practice.
- Author
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Lockhart PB, Durkin MJ, Blumenthal KG, Paumier TM, and Baddour LM
- Subjects
- Humans, Male, Female, Drug Hypersensitivity, Penicillins adverse effects, Antimicrobial Stewardship, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents adverse effects
- Abstract
Background: Approximately 10% of the US population self-reports a penicillin allergy history or are labeled as penicillin allergic. However, from 90% through 99% of these patients are not allergic on formal evaluation., Case Description: Patients labeled as penicillin allergic receive broader-spectrum and sometimes less-effective antibiotics, thereby contributing to increased treatment failures, antibiotic resistance, and adverse drug reactions. Self-reported penicillin allergy can be eliminated or classified as low-, medium-, or high-risk after a careful review of patient history. This allows these patients to be delabeled; that is, having any reference to their penicillin allergy history or of having an allergy to penicillin eliminated from their health records., Practical Implications: Oral health care professionals are ideally placed to partner in both antibiotic stewardship interventions by means of recognizing pervasive mislabeling and aiding in the process of delabeling., Competing Interests: Disclosure Dr. Blumenthal reports having a grant from Thermo Fisher related to penicillin allergy diagnostics. None of the remaining authors reported any disclosures., (Copyright © 2024 American Dental Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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