1. Change in Inflammatory Markers and Cognitive Status in the Oldest‐Old Women from the Study of Osteoporotic Fractures
- Author
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Metti, Andrea L, Yaffe, Kristine, Boudreau, Robert M, Ganguli, Mary, Lopez, Oscar L, Stone, Katie L, and Cauley, Jane A
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Trials and Supportive Activities ,Dementia ,Acquired Cognitive Impairment ,Clinical Research ,Brain Disorders ,Aging ,Neurosciences ,Neurological ,Aged ,Aged ,80 and over ,Biomarkers ,Cognition ,Cognition Disorders ,Disease Progression ,Female ,Follow-Up Studies ,Forecasting ,Humans ,Inflammation ,Neuropsychological Tests ,Osteoporotic Fractures ,Retrospective Studies ,Risk Factors ,inflammation ,oldest old ,mild cognitive impairment ,dementia ,Medical and Health Sciences ,Geriatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
ObjectivesTo determine the association between interleukin-6 (IL-6), IL-6 soluble receptor (sR), and soluble tumor necrosis factor receptor-1 (sTNF-R1) and cognitive status in the oldest-old women.DesignTwenty-year longitudinal cohort study.SettingFour clinical sites in the United States.ParticipantsWomen from the Study of Osteoporotic Fractures (N = 905; mean age 88.3 ± 2.8 at cognitive status adjudication).MeasurementsAt Year 20, cognitive status was adjudicated as normal, mild cognitive impairment (MCI), or dementia. Inflammatory markers were measured from blood serum at Years 10 and 16 in a random sample of women.ResultsOver 10 years, 199 (22.0%) women developed MCI and 145 (16.0%) dementia. There were no significant associations between IL-6 or sTNF-R1 and cognitive status. High IL-6-sR (≥ 37,401.36 pg/mL, highest tertile) at Year 16 was significantly associated with lower risk of dementia (odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.30-0.97) than in women with lower levels (
- Published
- 2014