1. Higher Levels of Cystatin C Are Associated with Worse Cognitive Function in Older Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Cognitive Study
- Author
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Yaffe, Kristine, Kurella‐Tamura, Manjula, Ackerson, Lynn, Hoang, Tina D, Anderson, Amanda H, Duckworth, Mark, Go, Alan S, Krousel‐Wood, Marie, Kusek, John W, Lash, James P, Ojo, Akinlolu, Robinson, Nancy, Sehgal, Ashwini R, Sondheimer, James H, Steigerwalt, Susan, and Townsend, Raymond R
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Aging ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Kidney Disease ,Renal and urogenital ,Aged ,Biomarkers ,Cognition Disorders ,Cystatin C ,Female ,Humans ,Male ,Middle Aged ,Multivariate Analysis ,Neuropsychological Tests ,Prospective Studies ,Renal Insufficiency ,Chronic ,United States ,cystatin C ,cognition ,chronic kidney disease ,CRIC Study Investigators ,Medical and Health Sciences ,Geriatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
ObjectivesTo determine the association between cognition and levels of cystatin C in persons with chronic kidney disease (CKD).DesignProspective observational study.SettingChronic Renal Insufficiency Cohort Cognitive Study.ParticipantsIndividuals with a baseline cognitive assessment completed at the same visit as serum cystatin C measurement (N = 821; mean age 64.9, 50.6% male, 48.6% white).MeasurementsLevels of serum cystatin C were categorized into tertiles; cognitive function was assessed using six neuropsychological tests. Scores on these tests were compared across tertiles of cystatin C using linear regression and logistic regression to examine the association between cystatin C level and cognitive performance (1 standard deviation difference from the mean).ResultsAfter multivariable adjustment for age, race, education, and medical comorbidities in linear models, higher levels of cystatin C were associated with worse cognition on the modified Mini-Mental State Examination, Buschke Delayed Recall, Trail-Making Test Part (Trails) A and Part B, and Boston Naming (P
- Published
- 2014