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Start Over Author "Jose Rafael Romero" Journal journal of the american heart association: cardiovascular and cerebrovascular disease
2 results on '"Jose Rafael Romero"'

2. Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome‐Wide Association Study

Author

Minghua Liu, Farid Khasiyev, Sanjeev Sariya, Antonio Spagnolo‐Allende, Danurys L Sanchez, Howard Andrews, Qiong Yang, Alexa Beiser, Ye Qiao, Emy A Thomas, Jose Rafael Romero, Tatjana Rundek, Adam M Brickman, Jennifer J Manly, Mitchell SV Elkind, Sudha Seshadri, Christopher Chen, Saima Hilal, Bruce A Wasserman, Giuseppe Tosto, Myriam Fornage, and Jose Gutierrez

Subjects
chromosome 10q24.32, CNNM2, genome‐wide association studies, larger brain arterial diameters, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BADs is unknown. Methods and Results The authors studied 4150 participants from 6 geographically diverse population‐based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). Brain arterial diameters for 13 segments were measured and averaged to obtain a global measure of BADs as well as the posterior and anterior circulations. A genome‐wide association study revealed 14 variants at one locus associated with global BAD at genome‐wide significance (P

Published
2023
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