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Your search keyword '"Sinai C. Zyblewski"' showing total 2 results
Start Over Author "Sinai C. Zyblewski" Journal journal of the american heart association: cardiovascular and cerebrovascular disease
2 results on '"Sinai C. Zyblewski"'

1. Association of Digoxin Use With Transplant‐Free Interstage Survival in Infants Palliated With a Stage 1 Hybrid Procedure

Author

Reshma K. Reddy, Sinai C. Zyblewski, Shahryar M. Chowdhury, Justin Godown, Scott M. Bradley, David W. Brown, Rachel K. Duncan, Tyler N. Brown, Katherine E. Bates, L. LuAnn Minich, and John M. Costello

Subjects
digoxin, hybrid, interstage, single ventricle, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Digoxin prescription in patients with single‐ventricle physiology after stage 1 palliation is associated with reduced interstage death. Prior literature has primarily included patients having undergone the Norwood procedure. We sought to determine if digoxin prescription at discharge in infants following hybrid stage 1 palliation was associated with improved transplant‐free interstage survival. Methods and Results A retrospective multicenter cohort analysis was conducted using data from the National Pediatric Cardiology Quality Improvement Collaborative registry data from 2008 to 2021. Infants with functional single ventricles and aortic arch obstruction discharged home after the hybrid stage 1 palliation hospitalization were included. Patients were excluded if they had supraventricular tachycardia or conversion to Norwood operation. The primary outcome was transplant‐free survival. Multivariable logistic regression analysis including a propensity score for digoxin use identified associations between digoxin use and interstage death or transplant. Of 259 included infants from 45 sites, 158 (61%) had hypoplastic left heart syndrome. Forty‐nine percent had a gestational age ≤38 weeks, 18% had a birth weight

Published
2023
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2. Longitudinal Assessment of Growth in Hypoplastic Left Heart Syndrome: Results From the Single Ventricle Reconstruction Trial

Author

Martha L. Clabby, Phillip T. Burch, Ismee A. Williams, Victoria L. Pemberton, Jeffrey B. Anderson, Nancy A. Pike, Ryan R. Davies, David S. Cooper, Svetlana Khaikin, Steven D. Colan, Linda M. Lambert, Lynn A. Sleeper, Carolyn Dunbar-Masterson, Jane W. Newburger, Karen Uzark, David A. Hehir, Eric Gerstenberger, Jennifer S. Li, L. LuAnn Minich, Sinai C. Zyblewski, and Chitra Ravishankar

Subjects
Male, Pediatrics, medicine.medical_specialty, pediatrics, Body height, medicine.medical_treatment, growth, Treatment outcome, Norwood Procedures, Weight Gain, Hypoplastic left heart syndrome, Child Development, Secondary analysis, Medicine, risk factors, Humans, Original Research, business.industry, Congenital Heart Disease, Age Factors, Infant, Newborn, Infant, hypoplastic left heart syndrome, medicine.disease, Infant newborn, Body Height, medicine.anatomical_structure, Treatment Outcome, Ventricle, Child, Preschool, Norwood procedure, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Weight gain
Abstract

Background We sought to characterize growth between birth and age 3 years in infants with hypoplastic left heart syndrome who underwent the Norwood procedure. Methods and Results We performed a secondary analysis using the Single Ventricle Reconstruction Trial database after excluding patients z score ( LAZ ) and weight‐for‐age z score ( WAZ ) at birth and age 3 years and change in WAZ over 4 clinically relevant time periods. We identified correlates of change in WAZ and LAZ using multivariable linear regression with bootstrapping. Mean WAZ and LAZ were below average relative to the general population at birth ( P P =0.05, respectively) and age 3 years ( P WAZ occurred between birth and Norwood discharge; the greatest gain occurred between stage II and 14 months. At age 3 years, WAZ and LAZ were WAZ differed among time periods. Shunt type was associated with change in WAZ only in the Norwood discharge to stage II period; subjects with a Blalock‐Taussig shunt had a greater decline in WAZ than those with a right ventricle‐pulmonary artery shunt ( P =0.002). Conclusions WAZ changed over time and the predictors of change in WAZ varied among time periods. By age 3 years, subjects remained small and three times as many children were short as were underweight (>2 SD below normal). Failure to find consistent risk factors supports the strategy of tailoring nutritional therapies to patient‐ and stage‐specific targets. Clinical Trial Registration URL: http://clinicaltrials.gov/ . Unique identifier: NCT00115934.

Published
2014

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