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It has been clearly demonstrated that both lead and calcium are retained in the body in the bones and that the chemical behavior of certain lead and calcium salts in vitro are very similar. These facts suggested to one of us (J. C. A.) that perhaps the same physiologic variations which affect the elimination and excretion of calcium would similarly influence the lead stream. As a result of certain observations on animal and man,1it soon became apparent that an analogy existed between the metabolism of lead and of calcium. The administration of various decalcifying agents resulted in an increased excretion of lead. Conversely, forms of therapy promoting calcium retention were found to favor the storage of lead. Consequently in the treatment of lead poisoning a high calcium diet is employed until all the symptoms of intoxication have disappeared. Complete subsidence of symptoms usually occurs within as short a

That aniline derivatives produce methemoglobinemia has been shown repeatedly by many investigators. The mechanism of this reaction has been reviewed by Bernheim.1One molecule of aniline combines with two of hemoglobin to give two molecules of methemoglobin and one of p-hydroxyaniline. To our knowledge it has not been shown that 2-anilinoethanol causes formation of methemoglobin but from analogy this might be expected to occur in the course of its metabolism in the body. That such is the case was suspected when 2 men in a commercial plant developed cyanosis while using this compound under the name "phenyl ethanolamine." No immediate means of testing the blood for methemoglobin was available in the local hospital, so that the etiologic agent of the cyanosis could not be definitely established. Both men rapidly recovered. REPORT OF CASES Case 1.— S. R., a Lithuanian aged 52, began work at 7 a. m. on Nov.