1. Dissociations of Complexes Between Monovalent Metal Ions and Aromatic Amino Acid or Histidine
- Author
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Junfang Zhao, Houssain Ei Aribi, K. W. Michael Siu, Alan C. Hopkinson, and Tamer Shoeib
- Subjects
Models, Molecular ,Spectrometry, Mass, Electrospray Ionization ,Silver ,Collision-induced dissociation ,Metal ions in aqueous solution ,Inorganic chemistry ,Lithium ,Medicinal chemistry ,Metal ,Amino Acids, Aromatic ,chemistry.chemical_compound ,Ammonia ,Structural Biology ,Cations ,Histidine ,Spectroscopy ,chemistry.chemical_classification ,Chemistry ,Hydride ,Sodium ,Deuterium Exchange Measurement ,Water ,Carbon Dioxide ,Amino acid ,visual_art ,visual_art.visual_art_medium ,Hydroxide ,Hydrogen–deuterium exchange - Abstract
The fragmentations of [AA + M](+) complexes, where AA = Phe, Tyr, Trp, or His, and M is a monovalent metal (Li, Na, or Ag), have been exhaustively studied through collision-induced dissociation (CID) and through deuterium labeling. Dissociations of the Li- and Ag-containing complexes gave a large number of fragment ions; by contrast, the sodium/amino acid complexes have lower binding energies, and dissociation resulted in much simpler spectra, with loss of the entire ligand dominating. Unambiguous assignments of these fragment ions were made and formation mechanisms are proposed. Of particular interest are fragmentations in which the charge was retained on the organic fragment and the metal was lost, either as a metal hydride (AgH) or hydroxide (LiOH) or as the silver atom (Ag(•)).
- Published
- 2012
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