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A new highly selective and sensitive electrochemical sensor has been developed, whereby working electrode is modified with bimetallic Au-Pt alloy nanoparticles (NPs). Au-Pt alloy NPs were prepared by a facile method using non/less toxic chemicals. The optical properties of the synthesized NPs were studied by UV-Visible spectroscopy. The surface structure was characterized by X-ray diffraction and scanning electron microscopy. The NPs were found spherical with an average diameter of 14.6 nm. The electrochemical response of modified electrode with polypyrrole and Au-Pt alloy NPs toward the detection of rabeprazole (antiulcer drug) was systematically investigated though cyclic, square wave and differential pulse voltammetry methods. Under optimized conditions, the developed sensor showed its promise for the trace level (1.29 µM) detection of the analyte. Moreover, the designed sensor demonstrated excellent reproducibility and maintained its integrity in a wide pH range and different supporting electrolytes for the sensing of rabeprazole. The Au-Pt alloy NPs based electrochemical sensor exhibited good selectivity, high sensitivity and stability, fast response time, ease of use and reproducibility. [ABSTRACT FROM AUTHOR]