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This paper presents general, closed-form, and exact expressions for cumulative distribution function, probability density function and average value for the ratio of independent η-μ random variables, with arbitrary parameters. More specifically, the outage capacity with peak interference power constraint, the delay-limited capacity, and the ergodic capacity considering constraints on the interference power are derived for non-homogeneous environments containing multipath waves clusters. Numerical curves are presented to evaluate the effects of the general fading variables in spectrum sharing systems. Besides, the results are validated by performing Monte-Carlo simulations. Notably, the provided results find important applications in cognitive radio systems considering the spectrum sharing approach and channels modeled by η-μ distribution.