Search

Your search keyword '"Schwab, Stefan"' showing total 3 results
Start Over Author "Schwab, Stefan" Journal journal of the neurological sciences Publisher elsevier b.v.
3 results on '"Schwab, Stefan"'

3. Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution.

Author

Sauer, Roland, Gölitz, Philipp, Jacobi, Johannes, Schwab, Stefan, Linker, Ralf A., and Lee, De-Hyung

Subjects
*PROGRESSIVE multifocal leukoencephalopathy, *BRAIN stem, *IMMUNOSUPPRESSION, *KIDNEY transplantation, *EARLY diagnosis, *IMMUNE reconstitution inflammatory syndrome
Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare, opportunistic and often fatal disease of the CNS which may occur under immunosuppression in transplant patients. Brain stem PML is associated with a particularly bad prognosis. Here, we present a case of a renal transplant patient treated with mycophenolate mofetil (MMF) and tacrolimus who developed brain stem PML with limb ataxia, dysarthria and dysphagia. Diagnosis was established by typical MRI features and detection of JCV-DNA in the CSF. Immune reconstitution after stopping MMF and tacrolimus led to a complete and sustained remission of symptoms with improvement of the brain stem lesion over a follow-up over 20 months. In summary, early detection of PML and consequent treatment may improve neurological outcomes even in brain stem disease with a notorious bad prognosis. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results