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Start Over Author "Lee Jae chul" Journal journal of the neurological sciences
17 results on '"Lee Jae chul"'

2. Long-term observation of neuronal degeneration and microgliosis in the gerbil dentate gyrus after transient cerebral ischemia

Author

Ahn, Ji Hyeon, primary, Shin, Bich Na, additional, Park, Joon Ha, additional, Kim, In Hye, additional, Cho, Jeong Hwi, additional, Chen, BaiHui, additional, Lee, Tae-Kyeong, additional, Tae, Hyun-Jin, additional, Lee, Jae-Chul, additional, Cho, Jun Hwi, additional, Kang, Il Jun, additional, Kim, Young-Myeong, additional, Lee, Yun Lyul, additional, Won, Moo-Ho, additional, and Seo, Jeong Yeol, additional

Published
2016
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3. Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia

Author

Park, Joon Ha, primary, Shin, Bich Na, additional, Chen, Bai Hui, additional, Kim, In Hye, additional, Ahn, Ji Hyeon, additional, Cho, Jeong-Hwi, additional, Tae, Hyun-Jin, additional, Lee, Jae-Chul, additional, Lee, Choong-Hyun, additional, Kim, Young-Myeong, additional, Lee, Yun Lyul, additional, Kim, Sung Koo, additional, and Won, Moo-Ho, additional

Published
2015
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4. Failure in neuroprotection of remote limb ischemic postconditioning in the hippocampus of a gerbil model of transient cerebral ischemia

Author

Lee, Jae-Chul, primary, Tae, Hyun-Jin, additional, Chen, Bai Hui, additional, Cho, Jeong Hwi, additional, Kim, In Hye, additional, Ahn, Ji Hyeon, additional, Park, Joon Ha, additional, Shin, Bich-Na, additional, Lee, Hui Young, additional, Cho, Young Shin, additional, Cho, Jun Hwi, additional, Hong, Seongkweon, additional, Choi, Soo Young, additional, Won, Moo-Ho, additional, and Park, Chan Woo, additional

Published
2015
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5. Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing SODs expressions

Author

Kim, Dong Won, primary, Cho, Jeong-Hwi, additional, Cho, Geum-Sil, additional, Kim, In Hye, additional, Park, Joon Ha, additional, Ahn, Ji Hyeon, additional, Chen, Bai Hui, additional, Shin, Bich-Na, additional, Tae, Hyun-Jin, additional, Hong, Seongkweon, additional, Cho, Jun Hwi, additional, Kim, Young-Myeong, additional, Won, Moo-Ho, additional, and Lee, Jae-Chul, additional

Published
2015
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6. Ischemic preconditioning inhibits expression of Na + /H + exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia

Author

Lee, Jae-Chul, primary, Cho, Jeong-Hwi, additional, Kim, In Hye, additional, Ahn, Ji Hyeon, additional, Park, Joon Ha, additional, Cho, Geum-Sil, additional, Chen, Bai Hui, additional, Shin, Bich Na, additional, Tae, Hyun-Jin, additional, Park, Seung Min, additional, Ahn, Ji Yun, additional, Kim, Dong Won, additional, Cho, Jun Hwi, additional, Bae, Eun Joo, additional, Yong, Jun-Hwan, additional, Kim, Young-Myeong, additional, Won, Moo-Ho, additional, and Lee, Yun Lyul, additional

Published
2015
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7. Impact of hyperthermia before and during ischemia–reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia

Author

Kim, Min Joung, primary, Cho, Jun Hwi, additional, Cho, Jeong-Hwi, additional, Park, Joon Ha, additional, Ahn, Ji Hyeon, additional, Tae, Hyun-Jin, additional, Cho, Geum-Sil, additional, Yan, Bing Chun, additional, Hwang, In Koo, additional, Lee, Choong Hyun, additional, Bae, Eun Joo, additional, Won, Moo-Ho, additional, and Lee, Jae-Chul, additional

Published
2015
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8. Effects of ischemic preconditioning on VEGF and pFlk-1 immunoreactivities in the gerbil ischemic hippocampus after transient cerebral ischemia

Author

Park, Yoo Seok, primary, Cho, Jun Hwi, additional, Kim, In Hye, additional, Cho, Geum-Sil, additional, Cho, Jeong-Hwi, additional, Park, Joon Ha, additional, Ahn, Ji Hyeon, additional, Chen, Bai Hui, additional, Shin, Bich-Na, additional, Shin, Myoung Cheol, additional, Tae, Hyun-Jin, additional, Cho, Young Shin, additional, Lee, Yun Lyul, additional, Kim, Young-Myeong, additional, Won, Moo-Ho, additional, and Lee, Jae-Chul, additional

Published
2014
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9. Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia

Author

Lee, Choong Hyun, primary, Park, Joon Ha, additional, Cho, Jeong-Hwi, additional, Ahn, Ji Hyeon, additional, Yan, Bing Chun, additional, Lee, Jae-Chul, additional, Shin, Myoung Cheol, additional, Cheon, Seung Hwan, additional, Cho, Young Shin, additional, Cho, Jun Hwi, additional, Kwon, Young-Guen, additional, Lee, Dong-Keon, additional, Kim, Young-Myeong, additional, and Won, Moo-Ho, additional

Published
2014
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10. Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia

Author

Yan, Bing Chun, primary, Ohk, Taek Geun, additional, Ahn, Ji Hyeon, additional, Park, Joon Ha, additional, Chen, Bai Hui, additional, Lee, Jae-Chul, additional, Lee, Choong Hyun, additional, Shin, Myoung Cheol, additional, Hwang, In Koo, additional, Moon, Seung Myung, additional, Cho, Jun Hwi, additional, and Won, Moo-Ho, additional

Published
2014
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11. Transient ischemia-induced change of CCR7 immunoreactivity in neurons and its new expression in astrocytes in the gerbil hippocampus

Author

Lee, Jae-Chul, primary, Ahn, Ji Hyeon, additional, Kim, In Hye, additional, Park, Joon Ha, additional, Yan, Bing Chun, additional, Cho, Geum-Sil, additional, Ohk, Taek Geun, additional, Park, Chan Woo, additional, Cho, Jun Hwi, additional, Kim, Young-Myeong, additional, Lee, Hui Young, additional, and Won, Moo-Ho, additional

Published
2014
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12. Ischemic preconditioning-induced neuroprotection against transient cerebral ischemic damage via attenuating ubiquitin aggregation

Author

Lee, Jae-Chul, primary, Kim, In Hye, additional, Cho, Geum-Sil, additional, Park, Joon Ha, additional, Ahn, Ji Hyeon, additional, Yan, Bing Chun, additional, Kwon, Hyuk Min, additional, Kim, Young-Myeong, additional, Cheon, Seung Hwan, additional, Cho, Jun Hwi, additional, Lee, Hui Young, additional, Won, Moo-Ho, additional, and Seo, Jeong Yeol, additional

Published
2014
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17. Ischemic preconditioning inhibits expression of Na+/H+ exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia.

Author

Lee, Jae-Chul, Cho, Jeong-Hwi, Kim, In Hye, Ahn, Ji Hyeon, Park, Joon Ha, Cho, Geum-Sil, Chen, Bai Hui, Shin, Bich Na, Tae, Hyun-Jin, Park, Seung Min, Ahn, Ji Yun, Kim, Dong Won, Cho, Jun Hwi, Bae, Eun Joo, Yong, Jun-Hwan, Kim, Young-Myeong, Won, Moo-Ho, and Lee, Yun Lyul

Subjects
*ISCHEMIA, *GERBILS, *HIPPOCAMPUS diseases, *PROSENCEPHALON, *BRAIN damage, *NEUROPROTECTIVE agents
Abstract

The participation of Na + /H + exchanger (NHE) in neuronal damage/death in the hippocampal CA1 region (CA1) induced by transient forebrain ischemia has not been well established, although acidosis may be involved in neuronal damage/death. In the present study, we examined the effect of ischemic preconditioning (IPC) on NHE1 immunoreactivity following a 5 min of transient forebrain ischemia in gerbils. The animals used in the study were randomly assigned to four groups (sham-operated-group, ischemia-operated-group, IPC plus (+) sham-operated-group and IPC + ischemia-operated-group). IPC was induced by subjecting animals to 2 min of ischemia followed by 1 day of recovery. A significant neuronal loss was found in the stratum pyramidale (SP) of the CA1, not the CA2/3, of the ischemia-operated-group at 5 days post-ischemia. However, in the IPC + ischemia-operated-group, neurons in the SP of the CA1 were well protected. NHE1 immunoreactivity was not detected in any regions of the CA1-3 of the sham- and IPC + sham-operated-groups. However, the immunoreactivity was apparently expressed in the SP of the CA1-3 after ischemia, and the NHE1immunoreactivity was very weak 5 days after ischemia; however, at this point in time, strong NHE1immunoreactivity was found in astrocytes in the CA1. In the CA2/3, NHE1immunoreactivity was slightly changed, although NHE1immunoreactivity was expressed in the SP. In the IPC + ischemia-operated-groups, NHE1 immunoreactivity was also expressed in the SP of the CA1-3; however, the immunoreactivity was more slightly changed than that in the ischemia-operated-groups. In brief, our findings show that IPC dramatically protected CA1 pyramidal neurons and strongly inhibited NHE1 expression in the SP of the CA1 after ischemia–reperfusion. These findings suggest that the inhibition of NHE1 expression may be necessary for neuronal survival from transient ischemic damage. [ABSTRACT FROM AUTHOR]

Published
2015
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