1. Lactate stress test in the diagnosis of mitochondrial myopathy
- Author
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C Cerny-Zacharias, Mamoli B, S. Shorny, J Capek, Reginald E. Bittner, B Pelzl, Josef Finsterer, and R Messner
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Stress testing ,Physical exercise ,Mitochondrion ,Sensitivity and Specificity ,Mitochondrial myopathy ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Lactic Acid ,Myopathy ,Aged ,business.industry ,Mitochondrial Myopathies ,Venous blood ,Metabolism ,Middle Aged ,medicine.disease ,Neurology ,Case-Control Studies ,Cardiology ,Exercise Test ,Female ,Neurology (clinical) ,Bicycle ergometer ,medicine.symptom ,business - Abstract
The aim of the study was to determine the sensitivity and specificity of the lactate stress test in the detection of mitochondrial myopathies. Thirty one healthy subjects, 10 patients with non-mitochondrial myopathy and 26 patients with mitochondrial myopathy underwent lactate stress testing at a standardized workload of 30 W during 15 min on a bicycle ergometer. Lactate was determined before the exercise (R1), 5, 10, 15 min after starting the exercise (S5, S10, S15) and 15 min after finishing the exercise (R2). A result was interpreted as pathologic if more than two of the five lactate values were above the corresponding upper reference limits. The upper reference limits for the venous lactate at R1, S5, S10, S15 and R2 were 1.9, 2.0, 2.1, 2.0 and 1.7 mmol/l respectively. The lactate stress test was pathologic in 1/10 of the non-mitochondrial myopathies and in 18/26 of the mitochondrial myopathies. The sensitivity of the lactate stress test was 69%. The specificity of the test was 90%. In conclusion, the lactate stress test proved to be helpful for evaluating the integrity of the oxidative metabolism in the majority of patients with mitochondrial myopathy.
- Published
- 1998