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Start Over Author "Mackintosh CL" Journal journal of the royal college of physicians of edinburgh
5 results on '"Mackintosh CL"'

2. Staphylococcus AureusEndocarditis associated with Injecting New Psychoactive Substances

Author

Joshi, SS, Henderson, N, Griffith, DJ, Henriksen, PA, Denvir, MA, Macsween, KF, Mackintosh, CL, and Inverarity, D

Abstract

Background Staphylococcus aureusinfective endocarditis (IE) associated with injection of new psychoactive substances (NPS) in Edinburgh from 2014 to 2016 was observed. We compared these infections with a series of S. aureusIE cases in a non-injecting population within Edinburgh.Methods NPS-associated S. aureusIE diagnosed between 1 January 2014 and 31 May 2016 in persons who inject drugs (PWID) were compared with a series of S. aureusIE cases from non-PWID.Results There was a fourfold increase in the annual incidence of S. aureusIE, mainly due to NPS use in PWID. A larger vegetation diameter was seen on echocardiogram in PWID vs non-PWID (median 1.7 cm vs 0.65 cm; p = 0.009) with more embolic complications in PWID (15 PWID vs 1 non-PWID; p = 2.1 x 10-7) but no difference in 90-day mortality (2 PWID vs 4 non-PWID; p = 0.39).Conclusions NPS-associated S. aureusIE correlated with complications, such as deep organ embolic abscesses, that were different from non-PWID S. aureusIE. The alarming increase in incidence resolved with targeted public health and legislative measures.

Published
2018
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5. Performance status: A key factor in predicting mortality in the first wave of COVID-19 in South-East Scotland.

Author

Mutch CP, Ross DA, Bularga A, Nicola Rose Cave R, Chase-Topping ME, Anand A, Mills NL, Koch O, Mackintosh CL, and Perry MR

Subjects
Humans, Male, Aged, Female, SARS-CoV-2, Intensive Care Units, Hospitalization, Risk Factors, Hospital Mortality, Retrospective Studies, COVID-19
Abstract

Background: COVID-19 mortality risk factors have been established in large cohort studies; long-term mortality outcomes are less documented., Methods: We performed multivariable logistic regression to identify factors associated with in-patient mortality and intensive care unit (ICU) admission in symptomatic COVID-19 patients admitted to hospitals in South-East Scotland from 1st March to 30th June 2020. One-year mortality was reviewed., Results: Of 726 patients (median age 72; interquartile range: 58-83 years, 55% male), 104 (14%) required ICU admission and 199 (27%) died in hospital. A further 64 died between discharge and 30th June 2021 (36% overall 1-year mortality). Stepwise logistic regression identified age >79 (odds ratio (OR), 4.77 (95% confidence interval (CI), 1.96-12.75)), male sex (OR, 1.83 (95% CI, 1.21-2.80)) and higher European Cooperative Oncology Group/World Health Organization performance status as associated with higher mortality risk., Discussion: Poor functional baseline was the predominant independent risk factor for mortality in COVID-19. More than one-third of individuals had died by 1 year following admission.

Published
2022
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