6 results on '"Skillington, Peter"'
Search Results
2. Surgical treatment for infarct-related ventricular septal defects
- Author
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Skillington, Peter D., Davies, Robert H., Luff, Andrew J., Williams, John D., Dawkins, Keith D., Conway, Neville, Lamb, Robert K., Shore, Darryl F., Monro, James L., Keith Ross, J., and Akins, Cary W.
- Abstract
A total of 101 patients (mean age 64.9 years) underwent surgical correction of postinfarction ventricular septal defect at this institution over a 15-year period (1973 to 1988). The overall early mortality rate was 20.8%, although the most recent experience with 36 patients (January 1987 to October 1988) has seen this decline to 11.1%. Factors found to influence early death significantly, when analyzed univariately, were as follows: (1) site of infarction (anterior 12.1%, inferior 32.6%, p = 0.02); (2) time interval between infarction and operation (<1 week 34.1%, >1 week 10.5%, p = 0.008); (3) cardiogenic shock (present 38.1%, absent 8.5%, p = 0.001). Nonsignificant variables included preoperative renal function, age, and concomitant coronary artery bypass, although older age (>65 years) became significant when examined in a multivariate fashion. Of the 80 hospital survivors, eight were subsequently found to have a recurrent or residual defect necessitating reoperation, with survival in seven. Late follow-up is 99% complete and reveals an actuarial survival rate for 100 patients of 71.1% at 5 years (95% confidence interval 60.6 to 80.0), and 40.0% at 10 years (95% confidence interval 21.7 to 58.4). A significant recent change in policy of not using coronary angiography in patients with a ventricular septal defect caused by anterior wall infarction has not resulted in any increase in either the early mortality or in the late prevalence of angina. The functional status of 38 surviving patients has been analyzed by a graded treadmill exercise protocol, whereas left ventricular functional assessment was by nuclear scan with additional information on mitral valve function by echocardiogram. Color Doppler flow mapping has been used to determine the presence of a residual defect. Most late survivors have limited exercise tolerance related to both cardiac and noncardiac factors. Left ventricular function is moderately impaired (mean ejection fraction = 0.39). However, many patients are elderly and have adapted to their residual symptoms without significant changes in life-style.
- Published
- 1990
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3. Optimal timing of Ross operation in children: A moving target?
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Konstantinov IE, Bacha E, Barron D, David T, Dearani J, d'Udekem Y, El-Hamamsy I, Najm HK, Del Nido PJ, Pizarro C, Skillington P, Starnes VA, and Winlaw D
- Abstract
Competing Interests: Conflict of Interest Statement The authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.
- Published
- 2024
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4. The Ross procedure using autologous support of the pulmonary autograft: techniques and late results.
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Skillington PD, Mokhles MM, Takkenberg JJ, Larobina M, O'Keefe M, Wynne R, and Tatoulis J
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- Adolescent, Adult, Aortic Aneurysm etiology, Aortic Aneurysm surgery, Aortic Valve Insufficiency diagnosis, Aortic Valve Stenosis diagnosis, Autografts, Blood Vessel Prosthesis Implantation adverse effects, Female, Heart Valve Prosthesis Implantation adverse effects, Humans, Male, Middle Aged, Prosthesis Design, Reoperation, Risk Factors, Time Factors, Treatment Outcome, Young Adult, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis surgery, Bioprosthesis, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Pulmonary Artery transplantation, Pulmonary Valve transplantation
- Abstract
Objectives: It is hypothesized that by performing radical aortic root manipulation and then autologous support for the pulmonary autograft in the Ross procedure, this will maintain aortic root size and should, in turn, lead to the demonstrated low incidence of late aortic regurgitation and need for reoperation on the aortic root and valve., Methods: Aortic root size was measured echocardiographically both preoperatively and then at second yearly intervals in 322 consecutive patients who underwent a Ross operation between October 1992 and June 2013 with autologous support of the pulmonary autograft root using the patient's own aorta. This technique, a variant of the inclusion cylinder method, has been developed with the aim of minimizing prosthetic materials in the aortic root., Results: Measures to reduce aortic root size included annulus reduction in 201 patients (62.4%) and reduction in aortic sinus or sinotubular junction in 159 patients (49.4%). Maximal aortic root diameter postoperatively at 5, 10, and 15 years was 34.0, 34.6, and 34.7 mm, respectively. Eleven reoperations were required during the study period for progressive aortic regurgitation (none for aortic root enlargement), with freedom from reoperation being 96% at both 15 years and 18 years. Preoperative pure aortic regurgitation, aortic annulus, and sinotubular junction enlargement were risk factors for reoperation., Conclusions: This inclusion method of pulmonary autograft implantation leads to minimal increases in aortic root size over time, with no reoperations for aortic root dilatation and a low requirement for aortic valve reoperation. The Ross procedure deserves to remain on the surgical menu for aortic valve replacement., (Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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5. An Australian risk prediction model for 30-day mortality after isolated coronary artery bypass: the AusSCORE.
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Reid C, Billah B, Dinh D, Smith J, Skillington P, Yii M, Seevanayagam S, Mohajeri M, and Shardey G
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- Aged, Aged, 80 and over, Australia, Female, Humans, Male, Middle Aged, ROC Curve, Risk Factors, Coronary Artery Bypass mortality, Models, Statistical
- Abstract
Objective: Our objective was to identify risk factors associated with 30-day mortality after isolated coronary artery bypass grafting in the Australian context and to develop a preoperative model for 30-day mortality risk prediction., Summary Background Data: Preoperative risk associated with cardiac surgery can be ascertained through a variety of risk prediction models, none of which is specific to the Australian population. Recently, it was shown that the widely used EuroSCORE model validated poorly for an Australian cohort. Hence, a valid model is required to appropriately guide surgeons and patients in assessing preoperative risk., Methods: Data from the Australasian Society of Cardiac and Thoracic Surgeons database project was used. All patients undergoing isolated coronary artery bypass grafting between July 2001 and June 2005 were included for analysis. The data were divided into creation and validation sets. The data in the creation set was used to develop the model and then the model was validated in the validation set. Preoperative variables with a P value of less than .25 in chi(2) analysis were entered into multiple logistic regression analysis to develop a preoperative predictive model. Bootstrap and backward elimination methods were used to identify variables that are truly independent predictors of mortality, and 6 candidate models were identified. The Akaike Information Criteria (AIC) and prediction mean square error were used to select the final model (AusSCORE) from this group of candidate models. The AusSCORE model was then validated by average receiver operating characteristic, the P value for the Hosmer-Lemeshow goodness-of-fit test, and prediction mean square error obtained from n-fold validation., Results: Over the 4-year period, 11,823 patients underwent cardiac surgery, of whom 65.9% (7709) had isolated coronary bypass procedures. The 30-day mortality rate for this group was 1.74% (134/7709). Factors selected as independent predictors in the preoperative isolated coronary bypass AusSCORE model were as follows: age, New York Heart Association class, ejection fraction estimate, urgency of procedure, previous cardiac surgery, hypercholesterolemia (lipid-lowering treatment), peripheral vascular disease, and cardiogenic shock. The average area under the receiver operating characteristic was 0.834, the P value for the Hosmer-Lemeshow chi(2) test statistic was 0.2415, and the prediction mean square error was 0.01869., Conclusion: We have developed a preoperative 30-day mortality risk prediction model for isolated coronary artery bypass grafting for the Australian cohort.
- Published
- 2009
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6. Short- and midterm outcomes of coronary artery bypass surgery performed by surgeons in training.
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Yap CH, Andrianopoulos N, Dinh TD, Billah B, Rosalion A, Smith JA, Shardey GC, Skillington PD, Tatoulis J, Mohajeri M, Yii M, and Reid CM
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- Aged, Confidence Intervals, Coronary Artery Bypass, Off-Pump methods, Coronary Artery Bypass, Off-Pump mortality, Coronary Disease mortality, Coronary Disease surgery, Education, Medical, Graduate methods, Female, Follow-Up Studies, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Postoperative Complications mortality, Probability, Proportional Hazards Models, Risk Assessment, Survival Analysis, Time Factors, Total Quality Management, Treatment Outcome, Clinical Competence, Coronary Artery Bypass methods, Coronary Artery Bypass mortality, Internship and Residency, Medical Staff, Hospital
- Abstract
Objective: The effect of training on outcomes in cardiac surgery is poorly studied. We aimed to study the results of coronary artery bypass grafting procedures performed by surgeons in training across our state with respect to short- and midterm postoperative outcomes., Methods: All coronary artery bypass grafting surgeries performed by trainee surgeons between July 2001 and December 2006 were compared with those performed by consultant surgeons using mandatory prospectively collected statewide data. Early mortality; prolonged ventilation or intensive care unit stay; return to operating theater for bleeding, stroke, myocardial infarction, or renal failure; and 5-year survival were compared using propensity score analysis., Results: A total of 7745 surgeries were included in this study. Trainees performed 983 (13%) surgeries. Trainee surgeries had longer perfusion and crossclamp times. Crude early postoperative outcomes were similar between trainee and consultant surgeries. After propensity score adjustment, early outcomes remained similar, with the exception of myocardial infarction (0.8% in trainee surgeries vs 0.4% in consultant surgeries, P = .046). Adjusted 1-, 3-, and 5-year survivals were similar between trainee and consultant surgeries: 95.3% versus 95.5%, 90.8% versus 92.0%, and 86.3% versus 87.1%, respectively., Conclusion: Coronary artery bypass grafting performed by trainee surgeons within a supervised program is safe with acceptable short- and midterm outcomes.
- Published
- 2009
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