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Start Over Author "P De Leyn" Journal journal of thoracic oncology
19 results on '"P De Leyn"'

2. OA 16.06 Mediastinal Staging by Videomediastinoscopy in Clinical N1 Non-Small Cell Lung Cancer: a Prospective Multicenter Study

Author

V. Kara, Sergi Call, Xavier B. D’Journo, Walter Klepetko, P. De Leyn, B Haager, Akif Turna, Ramón Rami-Porta, Laureano Molins, Johnny Moons, Clemens Aigner, Christophe Dooms, David Sánchez-Lorente, Pascal Thomas, B. Bethe, Kurt G. Tournoy, Bernward Passlick, Geoffrey Brioude, Thomas Klikovits, Herbert Decaluwé, J.C. Trujillo, and Roel Beelen

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, medicine.disease, Mediastinal staging, Multicenter study, Internal medicine, medicine, Non small cell, Radiology, business, Lung cancer
Published
2017

3. P1.13-007 Is Central Lung Tumor Location Really Predictive for Occult Mediastinal Nodal Disease in (Suspected) NSCLC Staged cN0 on PET-CT?

Author

Herbert Decaluwé, Christophe Deroose, Alessia Stanzi, Lieven Depypere, Johan Coolen, D. Van Raemdonck, Dirk De Ruysscher, W. De Wever, Kristiaan Nackaerts, Maarten Lambrecht, P. De Leyn, Johan Vansteenkiste, Johnny Moons, and Christophe Dooms

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, PET-CT, Oncology, business.industry, Medicine, Lung tumor, Radiology, business, Occult, Nodal disease
Published
2017

5. Outcome after PORT in ypN2 or R1/R2 versus no PORT in ypN0 Stage III-N2 NSCLC after Induction Chemotherapy and Resection

Author

Billiet, Charlotte, Peeters, Stéphanie, Decaluwé, Herbert, Vansteenkiste, Johan, Dooms, Christophe, Deroose, Christophe M., Hendrikx, Marc, De Leyn, Paul, Bulens, Paul, Karim, Rezaul, Le Péchoux, Cécile, Mebis, Jeroen, and De Ruysscher, Dirk

Abstract

We investigated patients with contemporarily staged and treated stage III-N2 NSCLC treated with induction chemotherapy and surgery with or without postoperative radiotherapy (PORT). We focused on survival and toxicity and investigated what additional PORT may offer in patients with ypN2 status or incomplete resection.

Published
2016
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6. Patterns of Locoregional Relapses in Patients with Contemporarily Staged Stage III-N2 NSCLC Treated with Induction Chemotherapy and Resection: Implications for Postoperative Radiotherapy Target Volumes

Author

Billiet, Charlotte, De Ruysscher, Dirk, Peeters, Stéphanie, Decaluwé, Herbert, Vansteenkiste, Johan, Dooms, Christophe, Deroose, Christophe M., De Leyn, Paul, Hendrikx, Marc, Bulens, Paul, Le Péchoux, Cécile, and Mebis, Jeroen

Abstract

Our aim was to evaluate locoregional relapse (LR) patterns after induction chemotherapy and surgery for stage III-N2 NSCLC staged with current standard methods and their impact on radiation target volumes for postoperative radiotherapy (PORT).

Published
2016
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7. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer

Author

Detterbeck, Frank C., Bolejack, Vanessa, Arenberg, Douglas A., Crowley, John, Donington, Jessica S., Franklin, Wilbur A., Girard, Nicolas, Marom, Edith M., Mazzone, Peter J., Nicholson, Andrew G., Rusch, Valerie W., Tanoue, Lynn T., Travis, William D., Asamura, Hisao, Rami-Porta, Ramón, Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Erich Eberhardt, Wilfried Ernst, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Erasmus, Jeremy, Flieder, Douglas, Godoy, Myrna, Goo, Jin Mo, Goodman, Lawrence R., Jett, Jim, de Leyn, Paul, Marchevsky, Alberto, MacMahon, Heber, Naidich, David, Okada, Morohito, Perlman, Marina, Powell, Charles, van Schil, Paul, Tsao, Ming S., Warth, Arne, Cavaco, F. Abad, Barrera, E. Ansótegui, Arca, J. Abal, Lamelas, I. Parente, Obrer, A. Arnau, Jorge, R. Guijarro, Ball, D., Bascom, G.K., Blanco Orozco, A.I., González Castro, M.A., Blum, M.G., Chimondeguy, D., Cvijanovic, V., Defranchi, S., de Olaiz Navarro, B., Escobar Campuzano, I., Macía Vidueira, I., Fernández Araujo, E., Andreo García, F., Fong, K.M., Francisco Corral, G., Cerezo González, S., Freixinet Gilart, J., García Arangüena, L., García Barajas, S., Girard, P., Goksel, T., González Budiño, M.T., González Casaurrán, G., Gullón Blanco, J.A., Hernández Hernández, J., Hernández Rodríguez, H., Herrero Collantes, J., Iglesias Heras, M., Izquierdo Elena, J.M., Jakobsen, E., Kostas, S., León Atance, P., Núñez Ares, A., Liao, M., Losanovscky, M., Lyons, G., Magaroles, R., De Esteban Júlvez, L., Mariñán Gorospe, M., McCaughan, B., Kennedy, C., Melchor Íñiguez, R., Miravet Sorribes, L., Naranjo Gozalo, S., Álvarez de Arriba, C., Núñez Delgado, M., Padilla Alarcón, J., Peñalver Cuesta, J.C., Park, J.S., Pass, H., Pavón Fernández, M.J., Rosenberg, M., Ruffini, E., Rusch, V., Sánchez de Cos Escuín, J., Saura Vinuesa, A., Serra Mitjans, M., Strand, T.E., Subotic, D., Swisher, S., Terra, R., Thomas, C., Tournoy, K., Van Schil, P., Velasquez, M., Wu, Y.L., and Yokoi, K.

Abstract

Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors can be classified to inform the eighth edition of the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses.

Published
2016
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8. The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer

Author

Detterbeck, Frank C., Franklin, Wilbur A., Nicholson, Andrew G., Girard, Nicolas, Arenberg, Douglas A., Travis, William D., Mazzone, Peter J., Marom, Edith M., Donington, Jessica S., Tanoue, Lynn T., Rusch, Valerie W., Asamura, Hisao, Rami-Porta, Ramón, Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Erich Eberhardt, Wilfried Ernst, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Erasmus, Jeremy, Flieder, Douglas, Godoy, Myrna, Goo, Jin Mo, Goodman, Lawrence R., Jett, Jim, de Leyn, Paul, Marchevsky, Alberto, MacMahon, Heber, Naidich, David, Okada, Morohito, Perlman, Marina, Powell, Charles, van Schil, Paul, Tsao, Ming S., and Warth, Arne

Abstract

It can be difficult to distinguish between a second primary and a metastasis in patients with lung cancer who have more than one pulmonary site of cancer.

Published
2016
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9. The IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Author

Detterbeck, Frank C., Nicholson, Andrew G., Franklin, Wilbur A., Marom, Edith M., Travis, William D., Girard, Nicolas, Arenberg, Douglas A., Bolejack, Vanessa, Donington, Jessica S., Mazzone, Peter J., Tanoue, Lynn T., Rusch, Valerie W., Crowley, John, Asamura, Hisao, Rami-Porta, Ramón, Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Erich Eberhardt, Wilfried Ernst, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Erasmus, Jeremy, Flieder, Douglas, Godoy, Myrna, Goo, Jin Mo, Goodman, Lawrence R., Jett, Jim, de Leyn, Paul, Marchevsky, Alberto, MacMahon, Heber, Naidich, David, Okada, Morohito, Perlman, Marina, Powell, Charles, van Schil, Paul, Tsao, Ming S., Warth, Arne, Cavaco, F. Abad, Barrera, E. Ansótegui, Arca, J. Abal, Lamelas, I. Parente, Obrer, A. Arnau, Jorge, R. Guijarro, Ball, D., Bascom, G.K., Blanco Orozco, A.I., González Castro, M.A., Blum, M.G., Chimondeguy, D., Cvijanovic, V., Defranchi, S., de Olaiz Navarro, B., Escobar Campuzano, I., Macía Vidueira, I., Fernández Araujo, E., Andreo García, F., Fong, K.M., Francisco Corral, G., Cerezo González, S., Freixinet Gilart, J., García Arangüena, L., García Barajas, S., Girard, P., Goksel, T., González Budiño, M.T., González Casaurrán, G., Gullón Blanco, J.A., Hernández, J., Hernández Rodríguez, H., Herrero Collantes, J., Iglesias Heras, M., Izquierdo Elena, J.M., Jakobsen, E., Kostas, S., León Atance, P., Núñez Ares, A., Liao, M., Losanovscky, M., Lyons, G., Magaroles, R., De Esteban Júlvez, L., Mariñán Gorospe, M., McCaughan, B., Kennedy, C., Melchor Íñiguez, R., Miravet Sorribes, L., Naranjo Gozalo, S., Álvarez de Arriba, C., Núñez Delgado, M., Padilla Alarcón, J., Peñalver Cuesta, J.C., Park, J.S., Pass, H., Pavón Fernández, M.J., Rosenberg, M., Ruffini, E., Rusch, V., Sánchez de Cos Escuín, J., Saura Vinuesa, A., Serra Mitjans, M., Strand, T.E., Subotic, D., Swisher, S., Terra, R., Thomas, C., Tournoy, K., Van Schil, P., Velasquez, M., Wu, Y.L., and Yokoi, K.

Abstract

Patients with lung cancer who harbor multiple pulmonary sites of disease have been challenging to classify; a subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee was charged with developing proposals for the eighth edition of the tumor, node, and metastasis (TNM) classification to address this issue.

Published
2016
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10. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Author

Detterbeck, Frank C., Marom, Edith M., Arenberg, Douglas A., Franklin, Wilbur A., Nicholson, Andrew G., Travis, William D., Girard, Nicolas, Mazzone, Peter J., Donington, Jessica S., Tanoue, Lynn T., Rusch, Valerie W., Asamura, Hisao, Rami-Porta, Ramón, Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Erich Eberhardt, Wilfried Ernst, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Erasmus, Jeremy, Flieder, Douglas, Godoy, Myrna, Goo, Jin Mo, Goodman, Lawrence R., Jett, Jim, de Leyn, Paul, Marchevsky, Alberto, MacMahon, Heber, Naidich, David, Okada, Morohito, Perlman, Marina, Powell, Charles, van Schil, Paul, Tsao, Ming S., and Warth, Arne

Abstract

Application of tumor, node, and metastasis (TNM) classification is difficult in patients with lung cancer presenting as multiple ground glass nodules or with diffuse pneumonic-type involvement. Clarification of how to do this is needed for the forthcoming eighth edition of TNM classification.

Published
2016
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11. Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study)

Author

Kreuter, Michael, Vansteenkiste, Johan, Fischer, Jürgen R., Eberhardt, Wilfried E., Zabeck, Heike, Kollmeier, Jens, Serke, Monika, Frickhofen, Norbert, Reck, Martin, Engel-Riedel, Walburga, Neumann, Silke, Thomeer, Michiel, Schumann, Christian, De Leyn, Paul, Graeter, Thomas, Stamatis, Georgios, Griesinger, Frank, and Thomas, Michael

Abstract

Adjuvant chemotherapy in non–small cell lung cancer (NSCLC) improves survival but is associated with significant toxicity. The Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (TREAT study) was designed to test the hypothesis that a protocol with reduced toxicity might improve feasibility of postoperative delivery of adjuvant chemotherapy drugs to patients with NSCLC, thereby improving compliance and, potentially, survival.

Published
2016
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12. European Trends in Preoperative and Intraoperative Nodal Staging: ESTS Guidelines

Author

P. Van Schil, T. Lerut, Didier Lardinois, Bernward Passlick, Marcin Zieliński, Walter Weder, David A. Waller, P. De Leyn, and Ramón Rami-Porta

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung Neoplasms, Staging, medicine.medical_treatment, Lymph node dissection, Mediastinal Neoplasms, Sensitivity and Specificity, Preoperative care, Mediastinoscopy, Pneumonectomy, Non-small cell lung cancer, Predictive Value of Tests, Carcinoma, Non-Small-Cell Lung, Monitoring, Intraoperative, Preoperative Care, medicine, Carcinoma, Humans, Lymph node, Neoplasm Staging, medicine.diagnostic_test, business.industry, Biopsy, Needle, medicine.disease, Immunohistochemistry, Mediastinal Neoplasm, Europe, Dissection, medicine.anatomical_structure, Oncology, Cardiothoracic surgery, Positron-Emission Tomography, Lymph Node Excision, Female, Lymph Nodes, Radiology, business
Abstract

Preoperative and intraoperative lymph node (LN) staging is of paramount importance for patients with non-small cell lung cancer. The Council of the European Society of Thoracic Surgery took the initiative to organize workshops on intraoperative and preoperative mediastinal LN staging. This resulted in specific guidelines. Relevant peer-reviewed publications on these subjects, the experience of the participants, and the opinion of the European Society of Thoracic Surgery members contributing online were used to reach a consensus. For primary staging, mediastinoscopy remains the gold standard for the superior mediastinal LNs. Invasive procedures can be omitted in patients with peripheral tumors and negative mediastinal and hilar nodes on positron emission tomography scan. Positron emission tomography-positive mediastinal findings should always be cytohistologically confirmed. New minimally invasive techniques that provide cytohistological diagnosis became available. Their specificity is high, but the negative predictive value is low. If they yield negative results, an invasive surgical technique remains indicated. For restaging, invasive techniques providing cytohistological information are advisable. Systematic nodal dissection is recommended in all cases to ensure complete resection. Lobe-specific systematic nodal dissection is acceptable for peripheral squamous T1 tumors if hilar and interlobar nodes are negative on frozen section studies. The report from the pathologist should describe the number of LNs removed and studied, the overall number of metastatic LNs in each station, and the status of the LN capsule. We hope that the adherence to these guidelines will standardize and improve preoperative and intraoperative LN staging and pathologic evaluation of non-small cell lung cancer.

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