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Advances in cancer therapy have been substantial in terms of molecular understanding of disease mechanisms, however these advances have not translated into increased survival in the majority of cancer types. One unsolved problem in current cancer therapeutics is the substantial immune suppression seen in patients. Conventionally, investigations in this area have focused on antigennonspecific immune suppressive molecules such as cytokines and T cell apoptosis inducing molecules such as Fas ligand. More recently, studies have demonstrated nanovesicle particles termed exosomes are involved not only in stimulation but also inhibition of immunity in physiological conditions. Interestingly, exosomes secreted by cancer cells have been demonstrated to express tumor antigens, as well as immune suppressive molecules such as PD-1L and FasL. Concentrations of exosomes from plasma of cancer patients have been associated with spontaneous T cell apoptosis, which is associated in some situations with shortened survival. In this paper we place the "exosome-immune suppression" concept in perspective of other tumor immune evasion mechanisms. We conclude by discussing a novel therapeutic approach to cancer immune suppression by extracorporeal removal of exosomes using hollow fiber filtration technology. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via the original article. [ABSTRACT FROM AUTHOR]

An abstract of the conference paper "Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients," by several researchers including, Nuno Costa, Ana E. Pires, and Ana M. Gabriel is presented.

An abstract of the conference paper "Adipocytes from the infrapatellar fat pad of OA patients modulate CD4+ T cell cytokine production," by several researchers including, Andreea Ioan-Facsinay, Joanneke C. Kwekkeboom, and Margreet Kloppenburg is presented.

An abstract of the conference paper "Extensive natural killer cell receptor phenotyping on NK and T cells discloses differences in RA and PsA, potentially mirroring diverse immunoregulatory functions," by several researchers including, Harry Dolstra, Frank Preijers, and Jan Spanholtz is presented.

An abstract of the conference paper "The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR V&#00DF repertoire but with an unmodified phenotype," by several researchers including, Nicolas Degauque, Caroline Ballet, and Yohann Foucher is presented.

An abstract of the conference paper "CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung," by several researchers including, Nicolas Glaichenhaus, Cyrille Mionnet, and Valérie Julia is presented.

An abstract of the conference paper "Alloantigenic recognition properties of CD8+ regulatory T cells," by several researchers including, Elodie Picarda, Ignacio Anegon, and Carole Guillonneau is presented.

An abstract of the conference paper "Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease," by several researchers including, Shen Dong, Sylvie Maiella, and Yuanyu Pang is presented.

An abstract of the conference paper "Identification of an osteoclastogenic CD4+ T cell population producing IL-17 and TNF&#03B1," by several researchers including, Hans Yssel, Claudine Blin-Wakkach, and Abdelilah Wakkach is presented.

An abstract of the conference paper "Lyoplate-based multiparameter flow cytometry for the analysis of T cell subsets in human immuno-monitoring studies," by several researchers including, Federica Villanova, Paola Di Meglio, and Susanne Heck is presented.

The article presents an abstract of a research paper that analyzes the effect of Rituximab treatment on T cells, submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases in Sitges-Barcelona, Spain from December 1-3, 2010.

The article presents an abstract of a research paper that examines the expression of different A-kinase Anchoring Proteins (AKAPs) in T cells isolated from systemic lupus erythematosus (SLE) T cells, submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases in Sitges-Barcelona, Spain from December 1-3, 2010.

The article presents an abstract of research paper on human regulatory T cell subsets submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases held at Barcelona, Spain, on December 1-3, 2010.

The article presents an abstract of research paper on T-cell receptor submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases held at Barcelona, Spain, on December 1-3, 2010.

The article presents an abstract of research paper on human T-cell subsets submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases held at Barcelona, Spain, on December 1-3, 2010.

The article presents an abstract of research paper on immunosurveillance by gamma delta T cells submitted at the 5th European Workshop on Immune-Mediated Inflammatory Diseases held at Barcelona, Spain, on December 1-3, 2010.