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Your search keyword '"dermatology life quality index (DLQI)"' showing total 2 results
Start Over Descriptor "dermatology life quality index (DLQI)" Journal journal of translational medicine
2 results on '"dermatology life quality index (DLQI)"'

1. Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome.

Author

Barrea, Luigi, Macchia, Paolo Emidio, Di Somma, Carolina, Napolitano, Maddalena, Balato, Anna, Falco, Andrea, Savanelli, Maria Cristina, Balato, Nicola, Colao, Annamaria, and Savastano, Silvia

Subjects
*PSORIASIS, *QUALITY of life, *METABOLIC syndrome, *BIOELECTRIC impedance, *MORTALITY, *C-reactive protein, *KINEMATICS, *REGRESSION analysis, *SEVERITY of illness index, *CASE-control method, *ODDS ratio, *DISEASE complications
Abstract

Background: Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body mass index (BMI) as a measure of obesity, data on phase angle (PhA), a direct measure by bioelectrical impedance analysis (BIA), used as a marker of cellular health and a predictor of morbidity and mortality in various diseases, are still lacking in psoriasis. In this case-control, cross-sectional study, we investigated the PhA in 180 pairs of adult psoriatic patients and healthy controls, evaluating also the potential use of the PhA as marker of the clinical severity, the quality of life, and the presence of the MetS in psoriatic patients.Methods: Anthropometric measures, metabolic profile and bioelectrical variables were evaluated. The clinical severity was assessed by standardized psoriasis area and severity index (PASI) score and c-reactive protein (CRP) levels, and the quality of life was evaluated by dermatology life quality index (DLQI). MetS was diagnosed according to Adult Treatment Panel III.Results: Psoriatic patients presented smaller PhA (p < 0.001) and higher prevalence MetS compared with controls. The PhA was significantly associated with number of parameters of MetS in both groups (p < 0.001). After adjusting for BMI, this association remained significant in psoriatic patients only (p < 0.001). Among psoriatic patients, the PhA was the major index value for the diagnosis of MetS (OR 5.87, 95 % CI 5.07-6.79) and was inversely associated with both PASI score and DLQI, independently of BMI (p < 0.001). At multiple regression analysis, the PhA well predicted the PASI score and DLQI. Based on ROC curves, the most sensitive and specific cutoffs of PhA to predict the highest PASI score and the lowest DQLI were ≤4.8° and ≤4.9°, respectively.Conclusions: We reported that psoriatic patients presented small PhAs, with a novel association between PhA, clinical severity, quality of life in psoriatic patients, and MetS. Further studies are required to validate the PhA's prognostic ability in assessing the clinical severity and MetS in psoriatic patients. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Author

Silvia Savastano, Anna Balato, Nicola Balato, Carolina Di Somma, Maria Cristina Savanelli, Annamaria Colao, Andrea Falco, Paolo Emidio Macchia, Maddalena Napolitano, Luigi Barrea, Barrea, Luigi, Macchia, PAOLO EMIDIO, DI SOMMA, Carolina, Napolitano, Maddalena, Balato, Anna, Falco, Andrea, Savanelli, MARIA CRISTINA, Balato, Nicola, Colao, Annamaria, and Savastano, Silvia

Subjects
Male, Genetics and Molecular Biology (all), Severity of Illness Index, Biochemistry, Dermatology life quality index (DLQI), Environmental factors, Metabolic syndrome (MetS), Phase angle (PhA), Psoriasis area and severity index (PASI) score, Biochemistry, Genetics and Molecular Biology (all), 0302 clinical medicine, Risk Factors, Electric Impedance, Odds Ratio, 030212 general & internal medicine, Medicine(all), Metabolic Syndrome, General Medicine, Dermatology Life Quality Index, Middle Aged, Biomechanical Phenomena, Regression Analysis, Female, Environmental factors Phase angle (PhA) Psoriasis area and severity index (PASI) score Dermatology life quality index (DLQI) Metabolic syndrome (MetS), Bioelectrical impedance analysis, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, Psoriasis Area and Severity Index, Internal medicine, Psoriasis, Severity of illness, medicine, Humans, Aged, Biochemistry, Genetics and Molecular Biology(all), business.industry, Research, Odds ratio, medicine.disease, Case-Control Studies, Quality of Life, Physical therapy, Metabolic syndrome, business, Body mass index
Abstract

Background: Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body mass index (BMI) as a measure of obesity, data on phase angle (PhA), a direct measure by bioelectrical impedance analysis (BIA), used as a marker of cellular health and a predictor of morbidity and mortality in various diseases, are still lacking in psoriasis. In this case–control, cross-sectional study, we investigated the PhA in 180 pairs of adult psoriatic patients and healthy controls, evaluating also the potential use of the PhA as marker of the clinical severity, the quality of life, and the presence of the MetS in psoriatic patients. Methods: Anthropometric measures, metabolic profile and bioelectrical variables were evaluated. The clinical severity was assessed by standardized psoriasis area and severity index (PASI) score and c-reactive protein (CRP) levels, and the quality of life was evaluated by dermatology life quality index (DLQI). MetS was diagnosed according to Adult Treatment Panel III. Results: Psoriatic patients presented smaller PhA (p < 0.001) and higher prevalence MetS compared with controls. The PhA was significantly associated with number of parameters of MetS in both groups (p < 0.001). After adjusting for BMI, this association remained significant in psoriatic patients only (p < 0.001). Among psoriatic patients, the PhA was the major index value for the diagnosis of MetS (OR 5.87, 95 % CI 5.07–6.79) and was inversely associated with both PASI score and DLQI, independently of BMI (p < 0.001). At multiple regression analysis, the PhA well predicted the PASI score and DLQI. Based on ROC curves, the most sensitive and specific cutoffs of PhA to predict the highest PASI score and the lowest DQLI were ≤4.8° and ≤4.9°, respectively. Conclusions: We reported that psoriatic patients presented small PhAs, with a novel association between PhA, clinical severity, quality of life in psoriatic patients, and MetS. Further studies are required to validate the PhA’s prognostic ability in assessing the clinical severity and MetS in psoriatic patients.

Published
2016
Full Text
View/download PDF

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