1. Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: study of 100 consecutive patients in a surgical intensive care unit.
- Author
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Lieberman JM, Marks WH, Cohn S, Jaicks R, Woode L, Sacchettini J, Fischer B, Moller B, and Burns G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers urine, Critical Care, Fatty Acid-Binding Protein 7, Fatty Acid-Binding Proteins, Female, Follow-Up Studies, Humans, Intestinal Mucosa blood supply, Ischemia urine, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Time Factors, Carrier Proteins urine, Infections urine, Multiple Organ Failure urine, Myelin P2 Protein urine, Neoplasm Proteins, Systemic Inflammatory Response Syndrome urine, Tumor Suppressor Proteins
- Abstract
Background: Intestinal mucosal ischemia and subsequent barrier dysfunction have been related to the development of organ dysfunction and death in the critically ill. We hypothesized that urine concentrations of intestinal fatty acid binding protein (IFABP), a sensitive marker of intestinal ischemia, might predict the development of the systemic inflammatory response syndrome (SIRS) and organ dysfunction., Methods: One hundred consecutive critically ill patients were prospectively studied for the development of infectious complications, organ dysfunction, and SIRS. Urine was collected daily for measurement of IFABP., Results: A total of 58 males and 42 females (mean age, 56 years; range,16-85 years) were studied. Of these 100 patients, 40 patients developed complications and 5 patients developed SIRS. IFABP was significantly elevated in all patients with SIRS, and IFABP levels peaked an average of 1.4 days (range, 0-7 days) before the diagnosis of SIRS., Conclusion: Elevated concentrations of urine IFABP correlated with the clinical development of SIRS. Studies to assess the utility of IFABP as a predictor of organ dysfunction and SIRS in the critically ill are warranted.
- Published
- 1998
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