Research suggests increases in substance use may be associated with symptoms of posttraumatic stress disorder (PTSD) following exposure to traumatic events (Boscarino, Adams, & Galea, 2006; Grieger, Fullerton, & Ursano, 2003; Pfefferbaum & Doughty, 2001; Stewart, Mitchell, Wright, & Loba, 2004). It has also been suggested that traumatic exposures may be a risk factor for future substance misuse (Chilcoat & Menard, 2003; Ouimette & Brown, 2003). Some evidence suggests that this association is due to the use of alcohol and other substances to ameliorate PTSD symptoms (Boscarino, Adams, & Galea, 2006; Chilcoat & Menard, 2003). Although studies of the association between substance use and exposure to psychological distress have a considerable history (Boscarino, 1981; Gottheil, Druley, Pashko, & Weinstein, 1987; Khantzian, 1990; Linsky, Colby, & Straus, 1991), these findings have not been consistent. For example, although experimental studies have linked alcohol use to psychological distress, findings from community-based studies have been less consistent (Castaneda, Lifshutz, Galanter, & Franco, 1994; Gottheil et al., 1987). There are studies that suggest that this relationship may include mediating factors (Cerda, Tracy, & Galea, 2011; Cerda, Vlahov, Tracy, & Galea, 2008; North, Ringwalt, Downs, Derzon, & Galvin, 2011), as well as some that suggest a direct association between PTSD and substance misuse (e.g., Kilpatrick et al., 2000). A recent large-scale national study of 34,635 adults, Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (Leeies, Pagura, Sareen, & Bolton, 2010), found that approximately 20% of individuals with PTSD may use alcohol and drugs to relieve their symptoms. Men were significantly more likely than women to engage in self-medication. In addition, another recent study suggested that fluctuation in PTSD symptoms are synchronized with alcohol-dependence symptoms and misuse of other substances (Ouimette, Read, Wade, & Tirone, 2010). Because alcohol is readily available in the US and it can be readily misused (National Institute on Alcohol Abuse and Alcoholism [NIAAA], 2000), an investigation of the degree to which alcohol problems are related to PTSD symptoms consequent to widespread traumatic exposure from terrorism is timely and potentially valuable. The present study examines the relationship between alcohol use before and following the World Trade Center (WTC) attacks in New York City and their relationship to PTSD and PTSD symptoms. Early postdisaster WTC studies documented an increased use of psychoactive substances, including alcohol, cigarettes, and marijuana and linked this use to PTSD (Vlahov et al., 2002, 2004). Previously we reported that greater exposure to the WTC attacks was associated with higher alcohol consumption at 1 year and 2 years after this event (Boscarino, Adams, & Galea, 2006) and we also reported that exposure to the attacks was associated with binge drinking at 1 year, but was not associated with binge drinking measured 2 years after the attacks. Alcohol misuse, as measured using a CAGE Questionnaire for alcohol, also was associated with greater exposure. After adjusting for exposure and other covariates, however, PTSD at Year 1 was not associated with alcohol use. This earlier report suggested that exposure to psychological trauma was associated with increases in problem drinking after exposure; absent was the longitudinal examination from predisaster to postdiaster of those with delayed onset PTSD. This a key focus of the present report. We expected that delayed-onset PTSD would be associated with both higher alcohol consumption and alcohol misuse up to 2 years after the attacks, independent of other factors such as demographics, history of traumatic exposures, recent stressful life events, and available psychosocial resources. To guide our analytical approach, we used a stress-process model (Adams & Boscarino, 2005). This model suggests that individuals subjected to stressors often respond physiologically through alterations in neuroendocrine functions (Boscarino, 1996), psychologically through alterations in cognitive status (Keane, Zimering, & Caddell, 1985), and behaviorally through, among other things, changes in use of psychoactive substances (Adams, Boscarino, & Galea, 2006a), as well as through help-seeking behaviors (Boscarino, Adams, & Figley, 2011). It is suggested that these stressor events could put individuals at risk for alcohol misuse because some persons may use psychoactive substances to help manage PTSD symptoms (e.g., hyperarousal or sleep disturbance), a phenomenon that has been conceptualized as a self-medication model of substance use (Bolton, Cox, Clara, & Sareen, 2006; Khantzian, 1990). Given recent reports (Cerda et al., 2008; Jacobson et al., 2008), and our previous work cited above describing the level of stress response (Adams, Boscarino, & Galea, 2006a), we did not expect the misuse of alcohol to rise to the level of symptoms of alcohol dependence (e.g., tolerance, withdrawal, etc.). Rather, we looked for the impact in greater frequency of binge drinking and increased alcohol consumption.