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Start Over Author "Fajkovic, Harun" Journal journal of urology
23 results on '"Fajkovic, Harun"'

1. MP32-16 FUNCTIONAL OUTCOMES IN FEMALE PATIENTS AFTER TRADITIONAL, ORGAN- AND NERVE-SPARING RADICAL CYSTECTOMY AND URINARY DIVERSION FOR BLADDER CANCER: A SYSTEMATIC REVIEW AND POOLED ANALYSES

Author

Laukhtina, Ekaterina, primary, Deimling, Markus Von, additional, Pradere, Benjamin, additional, Yanagisawa, Takafumi, additional, Rajwa, Pawel, additional, Kawada, Tatsushi, additional, Quhal, Fahad, additional, Pallauf, Maximilian, additional, Bianchi, Alberto, additional, Majdoub, Muhammad, additional, Mostafaei, Hadi, additional, Motlagh, Reza Sari, additional, Mori, Keiichiro, additional, Enikeev, Dmitry, additional, Fisch, Margit, additional, Moschini, Marco, additional, D`Andrea, David, additional, Soria, Francesco, additional, Albisinni, Simone, additional, Fajkovic, Harun, additional, RINK, MICHAEL, additional, Teoh, Jeremy Yuen-Chun, additional, Gontero, Paolo, additional, and Shariat, Shahrokh F., additional

Published
2023
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2. PD63-07 INTRAVESICAL THERAPY IN PATIENTS WITH INTERMEDIATE-RISK NON-MUSCLE-INVASIVE BLADDER CANCER: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF ONCOLOGIC OUTCOMES

Author

Laukhtina, Ekaterina, primary, Abufaraj, Mohammad, additional, Al-Ani, Abdallah, additional, Ali, Mustafa Rami, additional, Mori, Keiichiro, additional, Moschini, Marco, additional, Quhal, Fahad, additional, Motlagh, Reza Sari, additional, Pradere, Benjamin, additional, Schuettfort, Victor M., additional, Mostafaei, Hadi, additional, Katayama, Satoshi, additional, Grossmann, Nico С., additional, Fajkovic, Harun, additional, Soria, Francesco, additional, Enikeev, Dmitry, additional, and Shariat, Shahrokh F., additional

Published
2021
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3. Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma

Author

Foerster, Beat, primary, Abufaraj, Mohammad, additional, Petros, Firas, additional, Azizi, Mounsif, additional, Gupta, Mohit, additional, Schweitzer, Donald, additional, Margulis, Vitaly, additional, Iwata, Takehiro, additional, Kimura, Shoji, additional, Shabsigh, Ahmad, additional, Briganti, Alberto, additional, Ku, Ja H., additional, Muilwijk, Tim, additional, Kassouf, Wassim, additional, Matin, Surena F., additional, Spiess, Philippe E., additional, Pierorazio, Phillip M., additional, Hendricksen, Kees, additional, Shariat, Shahrokh F., additional, Clinton, Timothy, additional, Broutian, Tatevik, additional, Bandini, Marco, additional, Monteiro, Leonardo L., additional, Liao, Ross, additional, Moschini, Marco, additional, Bivalacqua, Trinity J., additional, Krabbe, Laura-Maria, additional, Nasu, Yasutomo, additional, Egawa, Shin, additional, Joniau, Steven, additional, John, Hubert, additional, van der Heijden, Michiel S., additional, Glybochko, Petr V., additional, Fajkovic, Harun, additional, Singla, Nirmish, additional, and Necchi, Andrea, additional

Published
2020
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4. Postoperative Nomogram for Relapse-Free Survival in Patients with High Grade Upper Tract Urothelial Carcinoma

Author

Krabbe, Laura-Maria, primary, Eminaga, Okyaz, additional, Shariat, Shahrokh F., additional, Hutchinson, Ryan C., additional, Lotan, Yair, additional, Sagalowsky, Arthur I., additional, Raman, Jay D., additional, Wood, Christopher G., additional, Weizer, Alon Z., additional, Roscigno, Marco, additional, Montorsi, Francesco, additional, Bolenz, Christian, additional, Novara, Giacomo, additional, Kikuchi, Eiji, additional, Fajkovic, Harun, additional, Rapoport, Leonid M., additional, Glybochko, Peter V., additional, Zigeuner, Richard, additional, Remzi, Mesut, additional, Bensalah, Karim, additional, Kassouf, Wassim, additional, and Margulis, Vitaly, additional

Published
2017
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5. 1764 COMPARATIVE ONCOLOGIC EFFECTIVENESS BETWEEN ROBOT-ASSISTED AND OPEN RADICAL CYSTECTOMY

Author

Ahmed Aboumohamed, Timothy Wilson, Giacomo Novara, Evanguelos Xylinas, Fajkovic Harun, Alon Z. Weizer, Ashok K. Hemal, Sia Daneshmand, Mani Menon, Wassim Kassouf, Koon Ho Rha, Derya Tilki, Francis Schanne, Ketan K. Badani, James O. Peabody, Gregory E. Wilding, Reza Ghavamian, Khurshid A. Guru, Michael Woods, H Martin Fritsche, Michael Stoekle, Shahrokh F. Shariat, Alex Mottrie, Yi Shi, Adam S. Kibel, John G. Pattaras, Stefan Siemer, Shamim Khan, Luis A. Kluth, Pierre I. Karakiewicz, Douglas S. Scherr, Joan Palou Redorta, Mevlana Derya Balbay, Peter Wiklund, Raj S. Pruthi, Piyush K. Agarwal, Yair Lotan, Maxine Sun, Lee Richstone, and Prokar Dasgupta

Subjects
Cystectomy, medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, General surgery, medicine, Robot, business
Published
2013

6. MP78-12 ASSOCIATION OF CIGARETTE SMOKING AND SMOKING CESSATION WITH BIOCHEMICAL RECURRENCE IN PATIENTS TREATED WITH RADICAL PROSTATECTOMY FOR PROSTATE CANCER

Author

Rieken, Malte, primary, Kluth, Luis, additional, Fajkovic, Harun, additional, Karakiewicz, Pierre, additional, Lotan, Yair, additional, Seitz, Christian, additional, Briganti, Alberto, additional, Rouprêt, Morgan, additional, Loidl, Wolfgang, additional, Lee, Richard, additional, Trinh, Quoc-Dien, additional, Nyirady, Peter, additional, Bachmann, Alexander, additional, Pourmand, Gholam-Reza, additional, and Shariat, Shahrokh, additional

Published
2015
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7. MP2-12 PROGNOSTIC IMPACT OF TUMOR STAGE ON POSITIVE LYMPH NODE STATUS IN UPPER TRACT UROTHELIAL CARCINOMA FOLLOWING RADICAL NEPHROURETERECTOMY

Author

Aziz, Atiqullah, primary, Shariat, Shahrokh F., additional, Kluth, Luis Alex, additional, Gakis, Georgios, additional, Fritsche, Hans-Martin, additional, Roupret, Morgan, additional, Fajkovic, Harun, additional, Soave, Armin, additional, Novara, Giacomo, additional, Pycha, Armin, additional, Remzi, Mesut, additional, Zigeuner, Richard, additional, Raman, Jay D., additional, Briganti, Alberto, additional, Bensalah, Karim, additional, Margulis, Vitaly, additional, Xylinas, Evanguelos, additional, Fisch, Margit, additional, and Rink, Michael, additional

Published
2015
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8. Impact of ABO Blood Type on Outcomes in Patients with Primary Nonmuscle Invasive Bladder Cancer

Author

Klatte, Tobias, primary, Xylinas, Evanguelos, additional, Rieken, Malte, additional, Kluth, Luis A., additional, Rouprêt, Morgan, additional, Pycha, Armin, additional, Fajkovic, Harun, additional, Seitz, Christian, additional, Karakiewicz, Pierre I., additional, Lotan, Yair, additional, Babjuk, Marko, additional, de Martino, Michela, additional, Scherr, Douglas S., additional, and Shariat, Shahrokh F., additional

Published
2014
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9. MP77-05 ASSOCIATION OF PERIOPERATIVE BLOOD TRANSFUSION WITH ONCOLOGIC OUTCOMES AFTER RADICAL NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA

Author

Rieken, Malte, primary, Schubert, Tina, additional, Xylinas, Evanguelos, additional, Kluth, Luis, additional, Rouprêt, Morgan, additional, Trinh, Quoc-Dien, additional, Lee, Richard, additional, Al Hussein Al Awamlh, Bashir, additional, Fajkovic, Harun, additional, Novara, Giacomo, additional, Margulis, Vitaly, additional, Lotan, Yair, additional, Martinez-Salamanca, Juan, additional, Matsumoto, Kazumasa, additional, Seitz, Christian, additional, Remzi, Mesut, additional, Karakiewicz, Pierre, additional, Scherr, Douglas, additional, Briganti, Alberto, additional, Bachmann, Alexander, additional, and Shariat, Shahrokh, additional

Published
2014
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10. MP56-07 COMPARISON OF THE EORTC TABLES AND THE NEWLY INTRODUCED EAU CATEGORIES FOR RISK STRATIFICATION OF PATIENTS WITH NON-MUSCLE-INVASIVE BLADDER CANCER

Author

Rieken, Malte, primary, Shariat, Shahrokh, additional, Al Hussein Al Awamlh, Bashir, additional, Kluth, Luis, additional, Crivelli, Joseph, additional, Chrystal, James, additional, Faison, Talia, additional, Lotan, Yair, additional, Karakiewicz, Pierre, additional, Babjuk, Marek, additional, Fajkovic, Harun, additional, Seitz, Christian, additional, Klatte, Tobias, additional, Pycha, Armin, additional, Bachmann, Alexander, additional, Gönen, Mithat, additional, and Xylinas, Evanguelos, additional

Published
2014
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11. Impact of Statin Use on Oncologic Outcomes in Patients with Urothelial Carcinoma of the Bladder Treated with Radical Cystectomy

Author

da Silva, Rodrigo Donalisio, primary, Xylinas, Evanguelos, additional, Kluth, Luis, additional, Crivelli, Joseph J., additional, Chrystal, James, additional, Chade, Daher, additional, Guglielmetti, Giuliano Betoni, additional, Pycha, Armin, additional, Lotan, Yair, additional, Karakiewicz, Pierre I., additional, Sun, Maxine, additional, Fajkovic, Harun, additional, Zerbib, Marc, additional, Scherr, Douglas S., additional, and Shariat, Shahrokh F., additional

Published
2013
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12. 358 DOES INCREASING THE NODAL YIELD IMPROVE OUTCOMES IN PATIENTS WITHOUT NODAL METASTASIS AT RADICAL PROSTATECTOMY?

Author

Kluth, Luis A, primary, Xylinas, Evanguelos, additional, Chun, Felix KH, additional, Fajkovic, Harun, additional, Karakiewicz, Pierre I, additional, Passoni, Niccolo, additional, Schmid, Marianne, additional, Herman, Mike, additional, Lotan, Yair, additional, Seitz>, Christian, additional, Schramek, Paul, additional, Remzi, Mesut, additional, Loidl, Wolfgang, additional, Guillonneau, Bertrand, additional, Briganti, Alberto, additional, Scherr, Douglas S, additional, Graefen, Markus, additional, Tewari, Ashutosh, additional, and Shariat, Shahrokh F, additional

Published
2013
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13. 1780 FEMALE GENDER IS ASSOCIATED WITH HIGHER RISK OF DISEASE RECURRENCE IN PATIENTS WITH PRIMARY T1 HIGH GRADE UROTHELIAL CARCINOMA OF THE BLADDER

Author

Kluth, Luis A, primary, Fajkovic, Harun, additional, Xylinas, Evanguelos, additional, Crivelli, Joseph J, additional, Passoni, Niccolo, additional, Rouprêt, Morgan, additional, Becker, Andreas, additional, Comploj, Evi, additional, Pycha, Armin, additional, Holmang, Sten, additional, Gupta, Amit, additional, Karakiewicz, Pierre I, additional, Lotan, Yair, additional, Gontero, Paolo, additional, Chun, Felix KH, additional, Scherr, Douglas S, additional, and Shariat, Shahrokh F, additional

Published
2013
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14. Impact of Smoking on Outcomes of Patients with a History of Recurrent Nonmuscle Invasive Bladder Cancer

Author

Rink, Michael, primary, Xylinas, Evanguelos, additional, Babjuk, Marko, additional, Hansen, Jens, additional, Pycha, Armin, additional, Comploj, Evi, additional, Lotan, Yair, additional, Sun, Maxine, additional, Karakiewicz, Pierre I., additional, Abdennabi, Joual, additional, Fajkovic, Harun, additional, Loidl, Wolfgang, additional, Chun, Felix K., additional, Fisch, Margit, additional, Scherr, Douglas S., additional, and Shariat, Shahrokh F., additional

Published
2012
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16. 1904 EXTRANODAL EXTENSION IS A POWERFUL PROGNOSTIC FACTOR IN BLADDER CANCER PATIENTS WITH LYMPH NODE METASTASIS

Author

Fajkovic, Harun, primary, Cha, Eugene, additional, Jeldres, Claudio, additional, Robinson, Brian, additional, Rink, Michael, additional, Chromecki, Thomas, additional, Breinl, Eckart, additional, Donner, Gerhard, additional, Svatek, Robert, additional, Tilki, Derya, additional, Bastian, Patrick, additional, Karakiewicz, Pierre, additional, Volkmer, Bjoern, additional, Novara, Giacomo, additional, Seitz, Christian, additional, Sonpavde, Guru, additional, Daneshmand, Siamak, additional, Lotan, Yair, additional, Faison, Talia, additional, Scherr, Douglas, additional, and Shariat, Shahrokh, additional

Published
2012
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17. 638 INTERNATIONAL VALIDATION OF THE PROGNOSTIC VALUE OF SUBCLASSIFICATION FOR AJCC STAGE PT3 UPPER TRACT UROTHELIAL CARCINOMA OF THE RENAL PELVIS

Author

Roscigno, Marco, primary, Cha, Eugene, additional, Seitz, Christian, additional, Novara, Giacomo, additional, Chromecki, Thomas F., additional, Fritsche, Hans-Martin, additional, Matsumoto, Kazumasa, additional, Walton, Thomas J., additional, Carballido, Joachin, additional, Da Pozzo, Luigi Filippo, additional, Bertini, Roberto, additional, Ficarra, Vincenzo, additional, Otto, Wolfgang, additional, Karakiewicz, Pierre I., additional, Pycha, Armin, additional, Fajkovic, Harun, additional, Naspro, Richard, additional, Scherr, Douglas S,, additional, Montorsi, Francesco, additional, and Shariat, Shahrokh F., additional

Published
2012
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18. 392 DISEASE-FREE SURVIVAL AS A SURROGATE FOR 5-YEAR OVERALL SURVIVAL IN UPPER TRACT UROTHELIAL CARCINOMA

Author

Cha, Eugene K., primary, Fajkovic, Harun, additional, Rink, Michael, additional, Pycha, Armin, additional, Dunning, Allison, additional, Novara, Giacomo, additional, Karakiewicz, Pierre I., additional, Margulis, Vitaly, additional, Raman, Jay D., additional, Lotan, Yair, additional, Kassouf, Wassim, additional, Fritsche, Hans-Martin, additional, Bensalah, Karim, additional, Weizer, Alon, additional, Kikuchi, Eiji, additional, Roscigno, Marco, additional, Remzi, Mesut, additional, Matsumoto, Kazumasa, additional, Zigeuner, Richard, additional, Scherr, Douglas S., additional, Mazumdar, Madhu, additional, Sonpavde, Guru, additional, and Shariat, Shahrokh F., additional

Published
2012
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19. 1400 CLINICAL NODAL STAGING SCORES FOR BLADDER CANCER A NEW PREOPERATIVELY NODAL ASSESSMENT TOOL

Author

Rink, Michael, primary, Ehdaie, Behfar, additional, Cha, Eugene K., additional, Svatek, Robert S., additional, Chromecki, Thomas, additional, Fajkovic, Harun, additional, Hansen, Jens, additional, Novara, Giacomo, additional, Daneshmand, Siamak, additional, Fradet, Yves, additional, Lotan, Yair, additional, Sagalowsky, Arthur, additional, Tilki, Derya, additional, Bastian, Patrick, additional, Kassouf, Wassim, additional, Fritsche, Hans-Martin, additional, Burger, Maximilian, additional, Izawa, Jonathan I., additional, Abdollah, Firas, additional, Karakiewicz, Pierre I., additional, Chun, Felix K., additional, Fisch, Margit, additional, Sonpavde, Guru, additional, Scherr, Douglas S., additional, Gonen, Mithat, additional, and Shariat, Shahrokh F., additional

Published
2012
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20. Prognostic Value of Extranodal Extension and Other Lymph Node Parameters in Patients With Upper Tract Urothelial Carcinoma

Author

Fajkovic, Harun, primary, Cha, Eugene K., additional, Jeldres, Claudio, additional, Donner, Gerhard, additional, Chromecki, Thomas F., additional, Margulis, Vitaly, additional, Novara, Giacomo, additional, Lotan, Yair, additional, Raman, Jay D., additional, Kassouf, Wassim, additional, Seitz, Christian, additional, Bensalah, Karim, additional, Weizer, Alon, additional, Kikuchi, Eiji, additional, Roscigno, Marco, additional, Remzi, Mesut, additional, Matsumoto, Kazumasa, additional, Breinl, Eckart, additional, Pycha, Armin, additional, Ficarra, Vincenzo, additional, Montorsi, Francesco, additional, Karakiewicz, Pierre I., additional, Scherr, Douglas S., additional, and Shariat, Shahrokh F., additional

Published
2012
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21. Risk Stratification of Organ Confined Bladder Cancer After Radical Cystectomy Using Cell Cycle Related Biomarkers

Author

Shariat, Shahrokh F., primary, Chromecki, Thomas F., additional, Cha, Eugene K., additional, Karakiewicz, Pierre I., additional, Sun, Maxine, additional, Fradet, Yves, additional, Isbarn, Hendrik, additional, Scherr, Douglas S., additional, Bastian, Patrick J., additional, Pummer, Karl, additional, Fajkovic, Harun, additional, Sagalowsky, Arthur I., additional, Ashfaq, Raheela, additional, Doblinger, Matthias, additional, Cote, Richard J., additional, and Lotan, Yair, additional

Published
2012
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22. Prediction of Cancer Specific Survival After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Development of an Optimized Postoperative Nomogram Using Decision Curve Analysis.

Author

Rouprêt, Morgan, Hupertan, Vincent, Seisen, Thomas, Colin, Pierre, Xylinas, Evanguelos, Yates, David R., Fajkovic, Harun, Lotan, Yair, Raman, Jay D., Zigeuner, Richard, Remzi, Mesut, Bolenz, Christian, Novara, Giacomo, Kassouf, Wassim, Ouzzane, Adil, Rozet, François, Cussenot, Olivier, Martinez-Salamanca, Juan I., Fritsche, Hans-Martin, and Walton, Thomas J.

Subjects
KIDNEY surgery, URETER surgery, TRANSITIONAL cell carcinoma, MULTIVARIATE analysis, NOMOGRAPHY (Mathematics), COHORT analysis
Abstract

Purpose: We conceived and proposed a unique and optimized nomogram to predict cancer specific survival after radical nephroureterectomy in patients with upper tract urothelial carcinoma by merging the 2 largest multicenter data sets reported in this population. Materials and Methods: The international and the French national collaborative groups on upper tract urothelial carcinoma pooled data on 3,387 patients treated with radical nephroureterectomy for whom full data for nomogram development were available. The merged study population was randomly split into the development cohort (2,371) and the external validation cohort (1,016). Cox regressions were used for univariable and multivariable analyses, and to build different models. The ultimate reduced nomogram was assessed using Harrell''s concordance index (c-index) and decision curve analysis. Results: Of the 2,371 patients in the nomogram development cohort 510 (21.5%) died of upper tract urothelial carcinoma during followup. The actuarial cancer specific survival probability at 5 years was 73.7% (95% CI 71.9–75.6). Decision curve analysis revealed that the use of the best model was associated with benefit gains relative to the prediction of cancer specific survival. The optimized nomogram included only 5 variables associated with cancer specific survival on multivariable analysis, those of age (p = 0.001), T stage (p <0.001), N stage (p = 0.001), architecture (p = 0.02) and lymphovascular invasion (p = 0.001). The discriminative accuracy of the nomogram was 0.8 (95% CI 0.77–0.86). Conclusions: Using standard pathological features obtained from the largest data set of upper tract urothelial carcinomas worldwide, we devised and validated an accurate and ultimate nomogram, superior to any single clinical variable, for predicting cancer specific survival after radical nephroureterectomy. [Copyright &y& Elsevier]

Published
2013
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23. Prognostic Value of Extranodal Extension and Other Lymph Node Parameters in Patients With Upper Tract Urothelial Carcinoma

Author

Jay D. Raman, Thomas F. Chromecki, Eugene K. Cha, Christian Seitz, Gerhard Donner, Harun Fajkovic, Claudio Jeldres, Karim Bensalah, Vitaly Margulis, Armin Pycha, Mesut Remzi, Giacomo Novara, Alon Z. Weizer, Yair Lotan, Wassim Kassouf, Vincenzo Ficarra, Kazumasa Matsumoto, Eiji Kikuchi, Francesco Montorsi, Marco Roscigno, Pierre I. Karakiewicz, Douglas S. Scherr, Eckart Breinl, Shahrokh F. Shariat, Weill Medical College of Cornell University [New York], Cancer Prognostics and Health Outcomes Unit, Université de Montréal (UdeM), Department of Urology, University of Texas Southwestern Medical Center [Dallas]- The University of Texas Health Science Center at Houston (UTHealth), Departement of Oncological and Surgical Sciences, Universita degli Studi di Padova, Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], University of Michigan [Ann Arbor], University of Michigan System, Keio University School of Medicine [Tokyo, Japan], Hospital Weinviertel-Korneuburg-Landesklinikum Korneuburg, General Hospital of Bolzano, Health Robotics S.r.l., Department of urology, Università Vita-Salute San Raffaele, Service d'urologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Fajkovic, Harun, Cha Eugene, K., Jeldres, Claudio, Donner, Gerhard, Chromecki Thomas, F., Margulis, Vitaly, Novara, Giacomo, Lotan, Yair, Raman Jay, D., Kassouf, Wassim, Seitz, Christian, Bensalah, Karim, Weizer, Alon, Kikuchi, Eiji, Roscigno, Marco, Remzi, Mesut, Matsumoto, Kazumasa, Breinl, Eckart, Pycha, Armin, Ficarra, Vincenzo, Montorsi, Francesco, Karakiewicz Pierre, I., Scherr Douglas, S., and Shariat Shahrokh, F.

Subjects
Male, Oncology, MESH: Chi-Square Distribution, urothelial carcinoma carcinoma, MESH: Lymphatic Metastasis, medicine.medical_treatment, 030232 urology & nephrology, carcinoma, Nephrectomy, lymph node excision, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Proportional Hazards Models, neoplasm metastasis, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, MESH: Ureteral Neoplasms, Stage (cooking), Lymph node, Neoadjuvant therapy, MESH: Treatment Outcome, MESH: Statistics, Nonparametric, MESH: Follow-Up Studies, MESH: Neoplasm Staging, Prognosis, MESH: Urinary Bladder Neoplasms, 3. Good health, Treatment Outcome, medicine.anatomical_structure, Chemotherapy, Adjuvant, MESH: Chemotherapy, Adjuvant, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Lymph, Radiology, MESH: Neoplasm Recurrence, Local, medicine.medical_specialty, Urology, urinary tract, urothelium, Statistics, Nonparametric, MESH: Prognosis, 03 medical and health sciences, Internal medicine, medicine, Carcinoma, Humans, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Chi-Square Distribution, MESH: Humans, Ureteral Neoplasms, MESH: Lymph Node Excision, business.industry, Carcinoma in situ, MESH: Retrospective Studies, Retrospective cohort study, medicine.disease, MESH: Male, MESH: Nephrectomy, Urinary Bladder Neoplasms, Neoplasm Recurrence, Local, business, MESH: Female, Follow-Up Studies
Abstract

International audience; PURPOSE: We assessed the prognostic value of extranodal extension and other lymph node parameters in a large multicenter cohort of patients with lymph node metastasis after radical nephroureterectomy. MATERIALS AND METHODS: We retrospectively analyzed the records of 222 patients with lymph node metastasis treated with radical nephroureterectomy for upper tract urothelial carcinoma without neoadjuvant therapy. Each lymph node metastasis was microscopically evaluated for extranodal extension. RESULTS: A median of 4 lymph nodes (IQR 8) was removed. Two lymph nodes (IQR 2) were positive. Lymph node density was 51.3% (IQR 71.7%). Overall 110 patients (49.5%) had extranodal extension, which was associated with more advanced pT stage (p = 0.026). On multivariable analysis extranodal extension was associated with disease recurrence (p = 0.01) and cancer specific mortality (p = 0.013). When stratified by a 30% cutoff, lymph node density was associated with disease recurrence and cancer specific mortality on univariable but not multivariable analysis (p = 0.048 and 0.049, respectively). Adding extranodal extension to a multivariable model including pT stage and tumor architecture improved predictive accuracy for disease recurrence from 70.3% to 74.5% (p

Published
2012

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