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Start Over Author "Nordling Jorgen" Journal journal of urology
11 results on '"Nordling Jorgen"'

2. 870 WHAT HELPS AND WHY? PREDICTING PATIENT OUTCOMES IN INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME (IC/BPS) WITH PAIN APPRAISALS AND BEHAVIOURAL COPING STRATEGIES

Author

Tripp, Dean A., primary, Nickel, J. Curtis, additional, Mulroy, Jillian, additional, Katz, Laura, additional, Pontari, Michel, additional, Moldwin, Robert, additional, Robert, Mayer, additional, Carr, Lesley, additional, Doggweiler, Ragi, additional, Yang, Claire, additional, Mishra, Nagendra, additional, and Nordling, Jorgen, additional

Published
2013
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3. Interstitial Cystitis/Painful Bladder Syndrome and Associated Medical Conditions With an Emphasis on Irritable Bowel Syndrome, Fibromyalgia and Chronic Fatigue Syndrome

Author

Nickel, J. Curtis, primary, Tripp, Dean A., additional, Pontari, Michel, additional, Moldwin, Robert, additional, Mayer, Robert, additional, Carr, Lesley K., additional, Doggweiler, Ragi, additional, Yang, Claire C., additional, Mishra, Nagendra, additional, and Nordling, Jorgen, additional

Published
2010
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5. PHENOTYPIC ASSOCIATIONS BETWEEN INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS) AND IRRITABLE BOWEL SYNDROME (IBS), FIBROMYALGIA (FM), CHRONIC FATIQUE SYNDROME (CFS): A CASE CONTROL STUDY

Author

Nickel, J Curtis, primary, Tripp, Dean A, additional, Pontari, Michel A, additional, Moldwin, Robert M, additional, Mayer, Robert, additional, Carr, Lesley K, additional, Doggweiler, Raggi, additional, Yang, Claire C, additional, Whitcomb, David, additional, Mishra, Nagendra, additional, and Nordling, Jorgen, additional

Published
2009
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9. 1552: Benign Prostatic Hyperplasia in Chronic Urinary Retention - A Prospective Randomized Multicenter Study - Prostalund Feedback Treatment vs Surgical Treatment

Author

Schelin, Sonny, primary, Walter, Steen, additional, Geertsen, Ulla, additional, Spångberg, Anders, additional, Duelund-Jacobsen, Jens, additional, Kroyer, Kurt, additional, Hjertberg, Hans, additional, Vatne, Vendil, additional, Richthoff, Jonas, additional, and Nordling, Jorgen, additional

Published
2005
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11. Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha.

Author

Bouchelouche K, Andresen L, Alvarez S, Nordling J, Nielsen OH, and Bouchelouche P

Subjects
Cells, Cultured, Humans, Chemokine CCL2 biosynthesis, Interleukin-1 physiology, Interleukin-13 physiology, Interleukin-4 physiology, Interleukin-6 biosynthesis, Muscle, Smooth cytology, Muscle, Smooth metabolism, Stem Cell Factor biosynthesis, Tumor Necrosis Factor-alpha physiology
Abstract

Purpose: Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha., Materials and Methods: HDSMCs were isolated and cultured using an explant technique. Protein expression, and the secretion of MCP-1, IL-6 and SCF were assayed by semiquantitative reverse transcriptase-polymerase chain reaction and specific enzyme-linked immunosorbent assay., Results: Unstimulated cells released low amounts of MCP-1, IL-6 and SCF. In cells stimulated by IL-4 MCP-1 mRNA was up-regulated by a mean factor +/- SD of 3.5 +/- 1.3, IL-6 mRNA was up-regulated by 3.8 +/- 1.3, the soluble form of SCF was up-regulated by 3.2 +/- 0.6 and the membrane bound form of SCF was up-regulated by 7.9 +/- 5.6. For IL-13 stimulated cells the values were 2.6 +/- 1.5, 3.6 +/- 2.1, 2.9 +/- 1.6 and 5.7 +/- 3.7, respectively. Soluble SCF mRNA expression was 5 times higher than the expression of mSCF mRNA. IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration (0.01 to 100 ng/ml) and time (0 to 24 hours) dependent manner. Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF., Conclusions: To our knowledge these findings demonstrate for the first time that HDSMCs express and release MCP-1 and IL-6, and show relatively high expression of soluble SCF. This supports our hypothesis that HDSMCs may have an active role by orchestrating the local inflammatory response in the bladder wall with possible implications for the pathophysiology of detrusor mastocytosis.

Published
2006
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