Search

BACKGROUND: The gain (eye-velocity/head-velocity) of the angular vestibuloocular reflex (aVOR) during head impulses can be increased while viewing near-targets and when exposed to unilateral, incremental retinal image velocity error signals. It is not clear however, whether the tonic or phasic vestibular pathways mediate these gain increases. OBJECTIVE: Determine whether a shared pathway is responsible for gain enhancement between vergence and adaptation of aVOR gain in patients with unilateral vestibular hypofunction (UVH). MATERIAL AND METHODS: 20 patients with UVH were examined for change in aVOR gain during a vergence task and after 15-minutes of ipsilesional incremental VOR adaptation (uIVA) using StableEyes (a device that controls a laser target as a function of head velocity) during horizontal passive head impulses. A 5 % aVOR gain increase was defined as the threshold for significant change. RESULTS: 11/20 patients had >5% vergence-mediated gain increase during ipsi-lesional impulses. For uIVA, 10/20 patients had >5% ipsi-lesional gain increase. There was no correlation between the vergence-mediated gain increase and gain increase after uIVA training. CONCLUSION: Vergence-enhanced and uIVA training gain increases are mediated by separate mechanisms and/or vestibular pathways (tonic/phasic). The ability to increase the aVOR gain during vergence is not prognostic for successful adaptation training. [ABSTRACT FROM AUTHOR]

The gaze stabilization test (GST) is a computerized test of the vestibulo-ocular reflex that reports maximum head velocity while maintaining fixed visual acuity. The GST thus assesses the vestibulo-ocular reflex differently from the dynamic visual acuity test (DVAT). The purpose of this study was to assess the reliability, stability, and validity of the GST in a healthy young and older population. Forty subjects (20 older adults with mean (SD) age of 76.3 (5.3) and 20 young controls with mean (SD) age of 25.2 (3.2)) performed the GST and DVAT assessments. The version of the GST used in this study has a tunneled mirror system to ensure a consistent participant distance of 4 m from the computer screen. All subjects repeated trials within 30 minutes of initial testing. Twenty subjects (10 from each age group) returned 7–10 days later to repeat the GST and DVAT assessments. Vestibular symptoms were assessed before and after GST and DVAT assessments. The mean (SD) GST scores for the older group were 123 (33) deg/s in the yaw plane and 108 (27) deg/s in the pitch plane. For the young group, mean (SD) GST scores were 157 (34) deg/s in the yaw plane and 141(25) deg/s in the pitch plane. There was a significant between-group difference for GST scores in both yaw and pitch planes (p< 0.01). The intraclass correlation coefficient (ICC) for GST scores performed on the same day was 0.75 in the yaw plane and 0.69 in the pitch plane. The ICC including the 20 subjects who repeated the GST within 7–10 days was 0.59 in the yaw plane and 0.54 in the pitch plane. In general, GST was more stable than DVAT. GST was more stable in younger vs. older subjects whereas DVAT was more stable in older vs. younger subjects. Concurrent validity, determined by Spearman correlation coefficients between GST and DVAT loss results were -0.62 in the yaw plane and -0.38 in the pitch plane (p< 0.02). These results suggest that the gaze stabilization test (GST) has good same-day test-retest reliability and stability in healthy young and older adults. The moderate correlation between same-day GST and DVAT loss scores suggest the two tests may be measuring similar, but different constructs. [ABSTRACT FROM AUTHOR]

Out-of-plane head movements performed during fast rotation produce non-compensatory nystagmus, sensations of illusory motion, and often motion sickness. Adaptation to this cross-coupled Coriolis stimulus has previously been demonstrated for head turns made in the yaw (transverse) plane of motion, during supine head-on-axis rotation. An open question, however, is if adaptation to head movements in one plane of motion transfers to head movements performed in a new, unpracticed plane of motion. Evidence of transfer would imply the brain builds up a generalized model of the vestibular sensory-motor system, instead of learning a variety of individual input/output relations separately. To investigate, over two days 9 subjects performed pitch head turns (sagittal plane) while rotating, before and after a series of yaw head turns while rotating. A Control Group of 10 subjects performed only the pitch movements. The vestibulo-ocular reflex (VOR) and sensations of illusory motion were recorded in the dark for all movements. Upon comparing the two groups we failed to find any evidence of transfer from the yaw plane to the pitch plane, suggesting that adaptation to cross-coupled stimuli is specific to the particular plane of head movement. The findings have applications for the use of centrifugation as a possible countermeasure for long duration spaceflight. Adapting astronauts to unconstrained head movements while rotating will likely require exposure to head movements in all planes and directions. [ABSTRACT FROM AUTHOR]