1. Hypophosphatemia. Causes and clinical consequences.
- Author
-
Forrester SD and Moreland KJ
- Subjects
- 2,3-Diphosphoglycerate, Adenosine Triphosphate biosynthesis, Animals, Cardiomyopathies etiology, Cardiomyopathies veterinary, Central Nervous System Diseases etiology, Central Nervous System Diseases veterinary, Diabetes Complications, Diabetes Mellitus veterinary, Diphosphoglyceric Acids biosynthesis, Hematologic Diseases etiology, Hematologic Diseases veterinary, Humans, Kidney Diseases etiology, Kidney Diseases veterinary, Muscular Diseases etiology, Muscular Diseases veterinary, Phosphates administration & dosage, Phosphates therapeutic use, Phosphorus deficiency, Phosphorus Metabolism Disorders complications, Phosphorus Metabolism Disorders etiology, Phosphates blood, Phosphorus metabolism, Phosphorus Metabolism Disorders veterinary
- Abstract
Severe hypophosphatemia (i.e., serum phosphorus concentration below 1 mg/dl) occurs infrequently in veterinary patients. It is most often associated with diabetic ketoacidosis in small animals. Phosphate is necessary for the production of 2,3 diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP); both are important for normal cellular metabolism. Consequences of severe hypophosphatemia may include hemolytic anemia, seizures, altered mentation, cardiomyopathy, and skeletal muscle weakness. Parenteral phosphate therapy is necessary in most cases of severe hypophosphatemia.
- Published
- 1989
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