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Your search keyword '"pituitary dependent hypercortisolism"' showing total 3 results
Start Over Descriptor "pituitary dependent hypercortisolism" Journal journal of veterinary internal medicine
3 results on '"pituitary dependent hypercortisolism"'

1. Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism

Author

Golinelli, Stefania, Fracassi, Federico, Bianchi, Ezio, Pöppl, Álan Gomes, Miceli, Diego Daniel, Benedicenti, Leontine, De Marco, Viviani, Cook, Audrey K, Castro, Laura Espada, Ramsey, Ian, Seo, Kyoung Won, Cantile, Carlo, Gandini, Gualtiero, Hulsebosch, Sean E, and Feldman, Edward C

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Brain Disorders, Dogs, Animals, Cushing Syndrome, Dog Diseases, Pituitary ACTH Hypersecretion, Mitotane, Muscles, dive bomber sound, median survival time, myotonia, pituitary dependent hypercortisolism, rigidity, treatment, Veterinary sciences
Abstract

BackgroundSevere muscle stiffness (SMS) in dogs with hypercortisolism (HC) is uncommon.ObjectivesTo evaluate signalment, presentation, treatments, and long-term outcomes of dogs with concurrent HC and SMS.AnimalsThirty-seven dogs.MethodsMedical records of dogs with HC and concurrent SMS were recruited from 10 institutions. Clinical information, test results, therapeutic responses, and survival times were reviewed.ResultsAll 37 dogs with HC and SMS had pituitary-dependent hypercortisolism (PDH); 36/37 weighed

Published
2023

2. Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism

Author

Stefania Golinelli, Federico Fracassi, Ezio Bianchi, Álan Gomes Pöppl, Diego Daniel Miceli, Leontine Benedicenti, Viviani De Marco, Audrey K. Cook, Laura Espada Castro, Ian Ramsey, Kyoung Won Seo, Carlo Cantile, Gualtiero Gandini, Sean E. Hulsebosch, and Edward C. Feldman

Subjects
dive bomber sound, median survival time, myotonia, pituitary dependent hypercortisolism, rigidity, treatment, Veterinary medicine, SF600-1100
Abstract

Abstract Background Severe muscle stiffness (SMS) in dogs with hypercortisolism (HC) is uncommon. Objectives To evaluate signalment, presentation, treatments, and long‐term outcomes of dogs with concurrent HC and SMS. Animals Thirty‐seven dogs. Methods Medical records of dogs with HC and concurrent SMS were recruited from 10 institutions. Clinical information, test results, therapeutic responses, and survival times were reviewed. Results All 37 dogs with HC and SMS had pituitary‐dependent hypercortisolism (PDH); 36/37 weighed

Published
2023
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3. Evaluation of baseline cortisol, endogenous ACTH, and cortisol/ACTH ratio to monitor trilostane treatment in dogs with pituitary-dependent hypercortisolism

Author

W A Burkhardt, Felicitas S Boretti, Claudia E Reusch, Nadja S Sieber-Ruckstuhl, University of Zurich, and Sieber-Ruckstuhl, Nadja S

Subjects
Male, endocrine system, medicine.medical_specialty, 10253 Department of Small Animals, Hydrocortisone, 3400 General Veterinary, Endogeny, Stimulation, Trilostane, Dogs, Adrenocorticotropic Hormone, Reference Values, Internal medicine, medicine, Animals, Dog Diseases, Enzyme Inhibitors, Prospective cohort study, Acth stimulation, Cushing Syndrome, General Veterinary, medicine.diagnostic_test, 630 Agriculture, business.industry, ACTH stimulation test, Dihydrotestosterone, Endocrinology, Pituitary dependent hypercortisolism, 570 Life sciences, biology, Female, business, hormones, hormone substitutes, and hormone antagonists, Hormone, medicine.drug
Abstract

Background The effectiveness of trilostane treatment is currently monitored by regular ACTH stimulation tests, which are time-consuming and expensive. Therefore, a monitoring system without a stimulation protocol and with less client expense would be preferable. Hypothesis/Objectives The aim of our study was to evaluate if baseline cortisol, endogenous ACTH (ACTH) concentration or the baseline cortisol to ACTH ratio (cortisol/ACTH ratio) could replace the ACTH stimulation test. Animals Forty trilostane-treated dogs with pituitary-dependent hypercortisolism (PDH) were included in this prospective study. Methods A total of 148 ACTH stimulation tests and 77 ACTH concentrations and cortisol/ACTH ratios were analyzed. Control of cortisol release was classified according to cortisol concentration after ACTH administration as excessive ( 5.4 μg/dL; group 3). Results Baseline cortisol concentrations had considerable overlap between excessively, adequately, and inadequately controlled dogs. Only baseline cortisol >4.4 μg/dL (in 12% of tests) was a reliable diagnosis of inadequate control. Endogenous ACTH concentrations did not differ between groups. The overlap of the cortisol/ACTH ratio between groups was large. Correct classification was only possible if the cortisol/ACTH ratio was >15, which occurred in 4% of tests. Conclusions and Clinical Importance To monitor trilostane treatment the ACTH stimulation test cannot be replaced by baseline cortisol, ACTH concentration, or the cortisol/ACTH ratio.

Published
2012

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