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Your search keyword '"Yuna Choi"' showing total 3 results
Start Over Author "Yuna Choi" Journal journal of veterinary medical science
3 results on '"Yuna Choi"'

1. Immunohistochemical analysis of periostin in the hearts of Lewis rats with experimental autoimmune myocarditis

Author

Taekyun Shin, Tae-Young Kang, Yuna Choi, Jiyoon Chun, Hanseul Oh, Meejung Ahn, and Jeongtae Kim

Subjects
Male, Pathology, medicine.medical_specialty, Myocarditis, 040301 veterinary sciences, Cardiac fibrosis, autoimmune disease, Periostin, Autoimmune Diseases, 0403 veterinary science, 03 medical and health sciences, Western blot, Fibrosis, medicine, Animals, 030304 developmental biology, periostin, Autoimmune disease, 0303 health sciences, General Veterinary, medicine.diagnostic_test, business.industry, Myocardium, fibrosis, 04 agricultural and veterinary sciences, Note, medicine.disease, Immunohistochemistry, Rats, Disease Models, Animal, Rats, Inbred Lew, smooth muscle actin, business, Cell Adhesion Molecules, Homeostasis
Abstract

Periostin plays a critical role in tissue regeneration and homeostasis. The aim of this study was to evaluate the changes in periostin levels in the hearts of rats with experimental autoimmune myocarditis (EAM). Western blot analysis revealed that the expression levels of periostin and alpha-smooth muscle actin were significantly increased at day 14 post-immunization. Immunohistochemical analysis indicated that periostin was expressed in macrophages and fibroblasts in the hearts of EAM-induced rats. In conclusion, these results suggest that increased periostin expression in macrophages and fibroblasts promotes cardiac fibrosis in EAM-induced rats, potentially by enhancing immune cell infiltration. Therefore, periostin should be further investigated as a candidate therapeutic target for myocarditis.

Published
2020
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2. Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats

Author

Meejung Ahn, Taekyun Shin, Yuna Choi, Jeongtae Kim, Hyojin Bang, and Gi Ok Kim

Subjects
Liver Cirrhosis, Male, 0301 basic medicine, Kupffer Cells, Metabolite, Kupffer cell, Connective tissue, CCL4, Pharmacology, Protective Agents, digestive system, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Isothiocyanates, Fibrosis, parasitic diseases, Pathology, medicine, Animals, General Veterinary, 010405 organic chemistry, Chemistry, fibrosis, allyl isothiocyanate, Note, medicine.disease, Allyl isothiocyanate, digestive system diseases, Rats, 0104 chemical sciences, 030104 developmental biology, medicine.anatomical_structure, Carbon tetrachloride, carbon tetrachloride, Hepatic fibrosis
Abstract

Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl4. Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl4 significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl4-intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining. In addition, Kupffer cell activation was significantly reduced in the AITC and CCl4 co-treated groups. Collectively, this study suggests that AITC mitigates hepatic fibrosis in rats repetitively exposed to CCl4 with concurrent regulation of Kupffer cell and monocyte activation.

Published
2018
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3. Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats.

Author

Jeongtae Kim, Hyojin Bang, Meejung Ahn, Yuna Choi, Gi Ok Kim, and Taekyun Shin

Subjects
CARBON tetrachloride, HEPATIC fibrosis, ALANINE aminotransferase, KUPFFER cells, CONNECTIVE tissue cells
Abstract

Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl4. Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl4 significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl4-intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining. In addition, Kupffer cell activation was significantly reduced in the AITC and CCl4 co-treated groups. Collectively, this study suggests that AITC mitigates hepatic fibrosis in rats repetitively exposed to CCl4 with concurrent regulation of Kupffer cell and monocyte activation. [ABSTRACT FROM AUTHOR]

Published
2018
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