1. Serum homocysteine concentration in dogs with immunosuppressant-responsive enteropathy
- Author
-
Eleonora Gori, Marco Pietra, Veronica Marchetti, Alessio Pierini, Elena Benvenuti, E. Bottero, Ilaria Lippi, Valentina Meucci, Benvenuti, Elena, Pierini, Alessio, Gori, Eleonora, Bottero, Enrico, Pietra, Marco, Lippi, Ilaria, Meucci, Valentina, and Marchetti, Veronica
- Subjects
Male ,medicine.medical_specialty ,Homocysteine ,040301 veterinary sciences ,canine ,folate ,Gastroenterology ,Cobalamin ,0403 veterinary science ,03 medical and health sciences ,chemistry.chemical_compound ,Dogs ,CCECAI ,Internal medicine ,medicine ,Internal Medicine ,Animals ,Enteropathy ,Dog Diseases ,030304 developmental biology ,Total protein ,0303 health sciences ,General Veterinary ,business.industry ,Serum homocysteine ,Significant difference ,Albumin ,04 agricultural and veterinary sciences ,medicine.disease ,Prognosis ,Enteritis ,chemistry ,Canine ,Folate ,HPLC ,Original Article ,Female ,Negative correlation ,business ,Immunosuppressive Agents - Abstract
Background: Homocysteine (HCY) was evaluated in healthy and chronic enteropathic dogs, however no studies on dogs with immunosuppressant-responsive enteropathy are available. Objectives: The aim was to evaluate serum HCY concentrations and its prognostic role in dogs with immunosuppressant-responsive enteropathy compared to healthy dogs. Methods: Serum HCY concentration was statistically compared between 24 healthy dogs and 29 dogs with immunosuppressant-responsive enteropathy. Correlation analyses between serum total protein, albumin (ALB), C-reactive protein (CRP), folate and cobalamin, and serum HCY concentration were performed in immunosuppressant-responsive enteropathic dogs. Results: The associations between serum HCY concentration and clinical, histological, endoscopic scores and follow-up were evaluated. Mean serum HCY concentration was higher in immunosuppressant-responsive enteropathic dogs compared to control dogs (30.22 ± 8.67 μmol/L vs. 5.26 ± 2.78 μmol/L; p < 0.0001). No association between serum HCY concentration and total protein, ALB, CRP, folate concentration as well as, clinical score, histological and endoscopic scores was found. A negative correlation between serum HCY concentration and cobalamin was noted (p = 0.0025, r = −0.54). No significant difference in HCY was found between responsive and non-responsive dogs or between survivors and non-survivors. Conclusions: Although, serum HCY concentration was higher in immunosuppressant-responsive enteropathy, its prognostic value remains unclear. However, further prospective, large-scale studies are warranted to better investigate the possible prognostic role of HCY in immunosuppressant-responsive enteropathic dogs.
- Published
- 2020