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Your search keyword '"Crooks, Emma T."' showing total 9 results
Start Over Author "Crooks, Emma T." Journal journal of virology
9 results on '"Crooks, Emma T."'

1. Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals

Author

Tomaras, Georgia D., primary, Binley, James M., additional, Gray, Elin S., additional, Crooks, Emma T., additional, Osawa, Keiko, additional, Moore, Penny L., additional, Tumba, Nancy, additional, Tong, Tommy, additional, Shen, Xiaoying, additional, Yates, Nicole L., additional, Decker, Julie, additional, Wibmer, Constantinos Kurt, additional, Gao, Feng, additional, Alam, S. Munir, additional, Easterbrook, Philippa, additional, Abdool Karim, Salim, additional, Kamanga, Gift, additional, Crump, John A., additional, Cohen, Myron, additional, Shaw, George M., additional, Mascola, John R., additional, Haynes, Barton F., additional, Montefiori, David C., additional, and Morris, Lynn, additional

Published
2011
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3. Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

Author

Binley, James M., primary, Lybarger, Elizabeth A., additional, Crooks, Emma T., additional, Seaman, Michael S., additional, Gray, Elin, additional, Davis, Katie L., additional, Decker, Julie M., additional, Wycuff, Diane, additional, Harris, Linda, additional, Hawkins, Natalie, additional, Wood, Blake, additional, Nathe, Cory, additional, Richman, Douglas, additional, Tomaras, Georgia D., additional, Bibollet-Ruche, Frederic, additional, Robinson, James E., additional, Morris, Lynn, additional, Shaw, George M., additional, Montefiori, David C., additional, and Mascola, John R., additional

Published
2008
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5. An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

Author

Nelson, Josh D., primary, Brunel, Florence M., additional, Jensen, Richard, additional, Crooks, Emma T., additional, Cardoso, Rosa M. F., additional, Wang, Meng, additional, Hessell, Ann, additional, Wilson, Ian A., additional, Binley, James M., additional, Dawson, Philip E., additional, Burton, Dennis R., additional, and Zwick, Michael B., additional

Published
2007
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6. Antibody Responses Elicited in Macaques Immunized with Human Immunodeficiency Virus Type 1 (HIV-1) SF162-Derived gp140 Envelope Immunogens: Comparison with Those Elicited during Homologous Simian/Human Immunodeficiency Virus SHIV SF162P4 and Heterologous HIV-1 Infection

Author

Derby, Nina R., primary, Kraft, Zane, additional, Kan, Elaine, additional, Crooks, Emma T., additional, Barnett, Susan W., additional, Srivastava, Indresh K., additional, Binley, James M., additional, and Stamatatos, Leonidas, additional

Published
2007
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7. Antibody Responses Elicited in Macaques Immunized with Human Immunodeficiency Virus Type 1 (HIV-1) SF162-Derived gp140 Envelope Immunogens: Comparison with Those Elicited during Homologous Simian/Human Immunodeficiency Virus SHIV SF162P4 and Heterologous HIV-1 Infection

Author

Derby, Nina R., primary, Kraft, Zane, additional, Kan, Elaine, additional, Crooks, Emma T., additional, Barnett, Susan W., additional, Srivastava, Indresh K., additional, Binley, James M., additional, and Stamatatos, Leonidas, additional

Published
2006
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8. Nature of Nonfunctional Envelope Proteins on the Surface of Human Immunodeficiency Virus Type 1

Author

Moore, Penny L., primary, Crooks, Emma T., additional, Porter, Lauren, additional, Zhu, Ping, additional, Cayanan, Charmagne S., additional, Grise, Henry, additional, Corcoran, Paul, additional, Zwick, Michael B., additional, Franti, Michael, additional, Morris, Lynn, additional, Roux, Kenneth H., additional, Burton, Dennis R., additional, and Binley, James M., additional

Published
2006
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9. Antibody Responses Elicited in Macaques Immunized with Human Immunodeficiency Virus Type 1 (HIV-1) SF162-Derived gp140 Envelope Immunogens: Comparison with Those Elicited during Homologous Simian/Human Immunodeficiency Virus SHIVSF162P4 and Heterologous HIV-1 Infection.

Author

Derby, Nina R., Kraft, Zane, Kan, Elaine, Crooks, Emma T., Barnett, Susan W., Srivastava, Indresh K., Binley, James M., and Stamatatos, Leonidas

Subjects
*RHESUS monkeys, *MACAQUES, *HIV, *HTLV, *VIRUSES
Abstract

The antibody responses elicited in rhesus macaques immunized with soluble human immunodeficiency virus (HIV) Env gp140 proteins derived from the R5-tropic HIV-1 SF162 virus were analyzed and compared to the broadly reactive neutralizing antibody responses elicited during chronic infection of a macaque with a simian/human immunodeficiency virus (SHIV) expressing the HIV-1 SF162 Env, SHIVSF162P4, and humans infected with heterologous HIV-1 isolates. Four gp140 immunogens were evaluated: SF162gp140, ΔV2gp140 (lacking the crown of the V2 loop), ΔV3gp140 (lacking the crown of the V3 loop), and ΔV2 ΔV3gp140 (lacking both the V2 and V3 loop crowns). SF162gp140 and ΔV2gp140 have been previously evaluated by our group in a pilot study, but here, a more comprehensive analysis of their immunogenic properties was performed. All four gp140 immunogens elicited stronger anti-gp120 than anti-gp41 antibodies and potent homologous neutralizing antibodies (NAbs) that primarily targeted the first hypervariable region (V1 loop) of gp120, although SF162gp140 also elicited anti-V3 NAbs. Heterologous NAbs were elicited by SF162gp140 and ΔV2gp140 but were weak in potency and narrow in specificity. No heterologous NAbs were elicited by ΔV3gp140 or ΔV2 ΔV3gp140. In contrast, the SHIVSF162P4-infected macaque and HIV-infected humans generated similar titers of anti-gp120 and anti-gp41 antibodies and NAbs of significant breadth against primary HIV-1 isolates, which did not target the V1 loop. The difference in V1 loop immunogenicity between soluble gp140 and virion-associated gp160 Env proteins derived from SF162 may be the basis for the observed difference in the breadth of neutralization in sera from the immunized and infected animals studied here. [ABSTRACT FROM AUTHOR]

Published
2006
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