1. Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo
- Author
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Abdel-Mohsen, Mohamed, Deng, Xutao, Liegler, Teri, Guatelli, John C, Salama, Mohamed S, Ghanem, Hussam El-din A, Rauch, Andri, Ledergerber, Bruno, Deeks, Steven G, Günthard, Huldrych F, Wong, Joseph K, and Pillai, Satish K
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Hepatitis ,Hepatitis - C ,Emerging Infectious Diseases ,HIV/AIDS ,Liver Disease ,Sexually Transmitted Infections ,Infectious Diseases ,Digestive Diseases ,5.1 Pharmaceuticals ,Infection ,Good Health and Well Being ,HIV ,Interferon-alpha ,Ribavirin ,Virus Replication ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4(+) T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r(2) = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.
- Published
- 2014