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9. Absence of Evidence for a Causal Link between Bovine Spongiform Encephalopathy Strain Variant L-BSE and Known Forms of Sporadic Creutzfeldt-Jakob Disease in Human PrP Transgenic Mice.

10. Generating Bona Fide Mammalian Prions with Internal Deletions.

11. Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice.

12. Accelerated, spleen-based titration of variant Creutzfeldt-Jakob disease infectivity in transgenic mice expressing human prion protein with sensitivity comparable to that of survival time bioassay.

13. Prion propagation in cells expressing PrP glycosylation mutants.

14. Infection of cell lines with experimental and natural ovine scrapie agents.

15. Prion strain- and species-dependent effects of antiprion molecules in primary neuronal cultures.

16. PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells.

17. Glycan-controlled epitopes of prion protein include a major determinant of susceptibility to sheep scrapie.

18. Prion infection of epithelial Rov cells is a polarized event.

19. Cultured peripheral neuroglial cells are highly permissive to sheep prion infection.

20. PrP polymorphisms tightly control sheep prion replication in cultured cells.

21. Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome.

22. Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins.

23. Organization of two transmissible gastroenteritis coronavirus membrane protein topologies within the virion and core.

24. Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.

25. The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability.

26. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein.

27. Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes.

28. Transmissible gastroenteritis coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway.

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