1. Civets Are Equally Susceptible to Experimental Infection by Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates
- Author
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Yonggang Liu, Yedong Yu, Yu Jiang, Jinding Chen, Xiangang Kong, Changchun Tu, Lin-Fa Wang, Bryan T. Eaton, Shoulin Gu, Gary Crameri, Ming Liao, Li Feng, Muping Wang, Donglai Wu, Yanwei Sun, Yuntao Guan, Nihong Liu, Changwen Li, Qing-Wen Meng, Hua Xuan, Jinfu Sun, Xunnan Yin, Hua Xiang, Chao-an Xin, Shengwang Liu, and Dexia Fu
- Subjects
viruses ,Immunology ,Cat Diseases ,Severe Acute Respiratory Syndrome ,medicine.disease_cause ,Microbiology ,Virus ,Viverridae ,Nidovirales ,Virology ,biology.animal ,medicine ,Animals ,Coronaviridae ,skin and connective tissue diseases ,Coronavirus ,biology ,Transmission (medicine) ,fungi ,virus diseases ,biology.organism_classification ,body regions ,Disease Models, Animal ,Severe acute respiratory syndrome-related coronavirus ,Insect Science ,Novel virus ,Cats ,Pathogenesis and Immunity ,Disease Susceptibility ,Viral disease - Abstract
Severe acute respiratory syndrome (SARS) was caused by a novel virus now known as SARS coronavirus (SARS-CoV). The discovery of SARS-CoV-like viruses in masked palm civets ( Paguma larvata ) raises the possibility that civets play a role in SARS-CoV transmission. To test the susceptibility of civets to experimental infection by different SARS-CoV isolates, 10 civets were inoculated with two human isolates of SARS-CoV, BJ01 (with a 29-nucleotide deletion) and GZ01 (without the 29-nucleotide deletion). All inoculated animals displayed clinical symptoms, such as fever, lethargy, and loss of aggressiveness, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies. Our data show that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01.
- Published
- 2005
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