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Your search keyword '"Wesselingh, Steven L"' showing total 4 results
Start Over Author "Wesselingh, Steven L" Journal journal of virology
4 results on '"Wesselingh, Steven L"'

1. Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in the nef and Long Terminal Repeat Regions

Author

Verity, Erin E., primary, Zotos, Dimitra, additional, Wilson, Kim, additional, Chatfield, Catherine, additional, Lawson, Victoria A., additional, Dwyer, Dominic E., additional, Cunningham, Anthony, additional, Learmont, Jennifer, additional, Dyer, Wayne, additional, Sullivan, John, additional, Churchill, Melissa, additional, Wesselingh, Steven L., additional, Gabuzda, Dana, additional, Gorry, Paul R., additional, and McPhee, Dale A., additional

Published
2007
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2. Genetic and Functional Analysis of R5X4 Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Derived from Two Individuals Homozygous for the CCR5Δ32 Allele

Author

Gray, Lachlan, primary, Churchill, Melissa J., additional, Keane, Niamh, additional, Sterjovski, Jasminka, additional, Ellett, Anne M., additional, Purcell, Damian F. J., additional, Poumbourios, Pantelis, additional, Kol, Chenda, additional, Wang, Bin, additional, Saksena, Nitin K., additional, Wesselingh, Steven L., additional, Price, Patricia, additional, French, Martyn, additional, Gabuzda, Dana, additional, and Gorry, Paul R., additional

Published
2006
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4. Longitudinal Analysis of Human Immunodeficiency Virus Type 1 nef/Long Terminal Repeat Sequences in a Cohort of Long-Term Survivors Infected from a Single Source.

Author

Churchill, Melissa J., Rhodes, David I., Learmont, Jennifer C., Sullivan, John S., Wesselingh, Steven L., Cooke, Ian R. C., Deacon, Nicholas J., and Gorry, Paul R.

Subjects
*HIV, *HTLV, *RETROVIRUSES, *ONCOGENIC viruses, *RNA viruses, *VIROLOGY, *MICROBIOLOGY
Abstract

We studied the evolution of human immunodeficiency virus type 1 (HIV-1) in a cohort of long-term survivors infected with an attenuated strain of HIV-1 acquired from a single source. Although the cohort members experienced differing clinical courses, we demonstrate similar evolution of HIV-1 nef/long-terminal repeat (LTR) sequences, characterized by progressive sequence deletions tending toward a minimal nef/LTR structure that retains only sequence elements required for viral replication. The in vivo pathogenicity of attenuated HIV-1 is therefore dictated by viral and/or host factors other than those that impose a unidirectional selection pressure on the nef/LTR region of the HIV-1 genome. [ABSTRACT FROM AUTHOR]

Published
2006
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