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Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of neuropathic pain induced by selective nerve injury (SND) on intestinal microflora diversity in C57 mice. Methods 36 C57 mice were randomly divided into SNI model group (n=18), sham-operation group (n=8), and control group (n = 10). At day 0,1, 3, 7, and 14 after modeling, mechanical pain threshold and thermal pain sensitivity tests were carried out. At day 14 after modeling, colon content (fresh feces) from all the mice were collected for intestinal microflora diversity analysis. Results One day after modeling, the mechanical pain threshold in SNI group decreased significantly (more than 70%) due to nerve injury, and the thermal pain threshold decreased by 40%, while sham group and control group had no significant decrease. SNI group showed foot hyperalgesia, and the difference was statistically significant compared with sham group and control group (P<0.001). Compared with control group, sham-operation group had a transient decrease in thermal pain threshold on the first day after modeling (P=0.006), but there was no difference in pain threshold between the two groups on the third day after modeling. The a-diversity analysis showed that the abundance of Observed, Chaol, ACE and Simpson in SNI group was significantly lower than that in control group (P<0.05). That is, SNI group had flora disorder due to pain stimulation. Observed, Chaol, ACE, and Simpson were less abundant in sham group than in control group (P<0.05) and the change was between SNI group and control group. Conclusion Neuropathic pain induced by SNI model resulted in the decrease of mechanical pain threshold and thermal pain threshold, which leads to the reduction of intestinal flora diversity in C57 mice. [ABSTRACT FROM AUTHOR]

Objective To compare the efficacy of radiofrequency thermocoagulation and pulsed radiofrequency for the ganglion impar in treating primary perineal pain. Methods We analyzed 79 patients with primary perineal pain who underwent radiofrequency thermocoagulation (group A) and pulsed radiofrequency (group B) in the ganglion impar from January 2020 to March 2022. VAS, excellent and good rates, sleep quality, postoperative medication usage, complications, and recurrence were evaluated before and 24 h, 1 W, 1 M, 3 M and 6 M after operation. The differences between the two groups were compared. Results The VAS score of group A gradually decreased at each level after operation, and the VAS score of group B gradually increased after 24 hours of operation. The differences between the two groups began to appear 1 week after operation, and the differences further increased with the extension of time (P<0.001). In six months after follow-up, the excellent and good rates of group A (86%) was significantly higher than that of group B (22%). In addition to postoperative perineal skin numbness, group A was superior to group B in improving sleep, postoperative oral medication (pregabalin and opioids), and disease recurrence (P<0.05). Conclusion Radiofrequency thermocoagulation for the ganglion impar can improve the quality of life by reducing pain, improving the excellent and good rates, improving sleep, and reducing recurrence a medication. The effect is better than that of pulsed radiofrequency. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors for non-specific low back pain (NLBP) in students of science and engineering colleges and universities so as to provide evidence for the prevention and treatment of NLBP in Chinese college students. Methods A total of 1200 samples were randomly selected from the first semester of the 2020-2021 academic year in science and engineering colleges, and a cross-sectional study was conducted by means of a questionnaire survey. According to the results of the prevalence survey, all the patients surveyed were taken as the case group, while the non-NLBP patients who matched in the same class, age and sex were selected as the control group. Binary logistic regression was used to screen risk factors for NLBP. Results Univariate analysis showed that the two groups differed significantly in the duration of daily continuous use of the computer, desk satisfaction, and pressure from life or study (P＜0.05). Binary logistic regression analysis found that the risk of developing NLBP was increased in those with longer duration of continuous use of the computer every day than those with shorter duration (OR=1.187, 95% CI: 1.082-1.303). Conclusion Duration of daily continuous use of the computer is an influencing factor in NLBP patients. Reducing the time of daily continuous use of the computer plays an important role in the prevention of NLBP. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of endoplasmic reticulum stress (ERS) C/EBP homologous protein homoiogousprotein (CHOP) on neuronal apoptosis after subarachnoid hemorrhage (SAH). Methods SAH model was established by endovascular perforation technique, intraventricular administration in SAH+sh-con group and SAH+sh-RNAi group. Neurological score was used to evaluate neurological behavior of the rats. Real-time PCR and Western blot were used to detect the expressions of caspase-3, Bim, Bcl-2 mRNA and CHOP protein. Neuronal apoptosis was detected by TUNEL. Results The expressions of Caspase-3 and Bim mRNA, and CHOP protein as well as neuronal apoptosis increased significantly; Bcl-2 mRNA decreased significantly in SAH group and SAH+sh-con group (P <0.05). The expressions of Caspase-3 and Bim mRNA, and CHOP protein as well as neuronal apoptosis decreased, while Bcl-2 mRNA expression increased in SAH+sh-RNAi group compared with SAH group and SAH+sh-con group (P<0.05). There was a positive correlation between the expression of CHOP protein and neuronal apoptosis (r=0.832, P <0.05). Conclusion Endoplasmic reticulum stress-apoptosis pathway is involved in the process of neuronal apoptosis after SAH. Inhibition of CHOP protein expression can effectively reduce apoptosis and improve prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of radiofrequency ablation on serum tumor necrosis factor alpha-α (TNF-α), interferon gamma-γ(IFN-γ) and interleukin 17 (IL-17) levels in patients with lumbar disc herniation. Methods We studied 276 patients with lumbar disc herniation admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2010 to December 2015. The experimental group received radiofrequency thermocoagulation and target ablation decompression treatment. In the same period, 133 healthy subjects were selected as control group. We collected the general information of the admitted patients and their serum before and after operation as well as serum of the control group. The changes of TNF-α, IFN-γ and IL-17 levels were detected by ELISA method. Results The levels of serum TNF-α, IFN-γ and IL-17 in the patients with lumbar disc herniation were significantly higher than those in the control group (P<0.05). Compared with those before operation, the serum levels of TNF-α, IFN-γ and IL-17 were decreased significantly in the recovery phase after radiofrequency ablation (P<0.05). Conclusion Frequency thermal coagulation target ablation decompression treatment of lumbar disc herniation can not only improve pain symptoms but also reduce the systemic inflammatory reactions. Therefore, it deserves clinical application. [ABSTRACT FROM AUTHOR]

Objective To investigate the levels of miR-19a and miR-19b expressions in cancer tissues and serum of patients with non-small cell lung cancer (NSCLC), and evaluate the potential of miR-19a and miR-19b as biomarkers of NSCLC. Methods Real time-PCR was used to detect the expressions of miR-19a and miR-19b in serum of normal people and patients with NSCLC and in cancer tissues and their corresponding non-tumor tissues. The diagnostic value of miR-19a and miR-19b for NSCLC was assessed by receiver operator characteristic (ROC) curve. Results The expression levels of serum miR-19a and miR-19b were significantly higher in patients with non-small cell lung cancer than in normal people (P<0.05). The expressions of miR-19a and miR-19b in NSCLC were much higher than in the adjacent normal tissues. For miR-19a the area under ROC curve was 0.989, and the sensitivity and specificity were 95.1 and 94.0. The area under ROC curve for miR-19b was 0.983, and the sensitivity and specificity were 93.4 and 94.0. Conclusion The high expressions of miR-19a and miR-19b are found in cancer tissues and serum from NSCLC patients. Therefore, they may be used as noninvasive biomarkers for diagnosis and prognosis of NSCLC. [ABSTRACT FROM AUTHOR]