1. Gitelman's and Bartter's Syndromes: From Genetics to the Molecular Basis of Hypertension and More.
- Author
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Ravarotto, Verdiana, Bertoldi, Giovanni, Stefanelli, Lucia Federica, Nalesso, Federico, and Calò, Lorenzo A.
- Subjects
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MOLECULAR genetics , *REGULATION of blood pressure , *RENIN-angiotensin system , *SYNDROMES , *HEPATORENAL syndrome , *HYPERTENSION - Abstract
Background: Gitelman's and Bartter's syndromes (GS/BS) are rare genetic tubulopathies characterized by electrolyte imbalance and activation of the renin-angiotensin-aldosterone system (RAAS). These syndromes have intriguing biochemical and hormonal abnormalities that lead them to be protected from hypertension and cardiovascular and renal remodeling. Summary: In this review, we explore the biochemical/molecular mechanisms induced by the activation of the RAAS and its counterregulatory arm which is particularly activated in GS/BS patients, in the context of blood pressure regulation. In addition, we report our findings in the context of the COVID-19 pandemic where we observed GS/BS subjects being protected from infection. Key Messages: The intracellular pathways induced by Ang II, starting from induction of oxidative stress and vasoconstriction, are crucial for the progression toward cardiovascular-renal remodeling and might be useful targets in order to reduce/halt the progression of Ang II/oxidative stress-induced cardiovascular-renal morbidity in several diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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