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Your search keyword '"Jaimes, Edgar A."' showing total 10 results
Start Over Author "Jaimes, Edgar A." Language english Journal kidney international
10 results on '"Jaimes, Edgar A."'

1. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Author

Murakami, Naoka, Mulvaney, Patrick, Danesh, Melissa, Abudayyeh, Ala, Diab, Adi, Abdel-Wahab, Noha, Abdelrahim, Maen, Khairallah, Pascale, Shirazian, Shayan, Kukla, Aleksandra, Owoyemi, Itunu O., Alhamad, Tarek, Husami, Samir, Menon, Madhav, Santeusanio, Andrew, Blosser, Christopher D., Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A., Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M., Cardarelli, Francesca, Drews, Reed E., Bassil, Claude, Swank, Jennifer L., Westphal, Scott, Mannon, Roslyn B., Shirai, Keisuke, Kitchlu, Abhijat, Ong, Song, Machado, Shana M., Mothi, Suraj S., Ott, Patrick A., Rahma, Osama, Hodi, F. Stephen, Sise, Meghan E., Gupta, Shruti, Leaf, David E., Devoe, Craig E., Wanchoo, Rimda, Nair, Vinay V., Schmults, Chrysalyne D., Hanna, Glenn J., Sprangers, Ben, Riella, Leonardo V., and Jhaveri, Kenar D.

Published
2021
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2. KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., Tesař, Vladimír, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Małyszko, Jolanta, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Porta, Camillo

Published
2020
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3. KDIGO Controversies Conference on onco-nephrology: understanding kidney impairment and solid-organ malignancies, and managing kidney cancer

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., ladimír Tesař, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Porta, Camillo, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Małyszko, Jolanta

Published
2020
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8. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice.

Author

Kim, Junghyun, Zarjou, Abolfazl, Traylor, Amie M, Bolisetty, Subhashini, Jaimes, Edgar A, Hull, Travis D, George, James F, Mikhail, Fady M, and Agarwal, Anupam

Subjects
*HEME oxygenase, *CARBON monoxide, *BILIVERDIN, *IRON, *CHROMATIN, *RHABDOMYOLYSIS, *NEPHROTOXICOLOGY
Abstract

Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, producing equimolar amounts of carbon monoxide, iron, and biliverdin. Induction of HO-1 is a beneficial response to tissue injury in diverse animal models of diseases including acute kidney injury. In vitro analysis has shown that the human HO-1 gene is transcriptionally regulated by changes in chromatin conformation, but whether such control occurs in vivo is not known. To enable such an analysis, we generated transgenic mice, harboring an 87-kb bacterial artificial chromosome expressing human HO-1 mRNA and protein and bred these mice with HO-1 knockout mice to generate humanized BAC transgenic mice. This successfully rescued the phenotype of the knockout mice including reduced birth rates, tissue iron overload, splenomegaly, anemia, leukocytosis, dendritic cell abnormalities, and survival after acute kidney injury induced by rhabdomyolysis or cisplatin nephrotoxicity. Transcription factors such as USF1/2, JunB, Sp1, and CTCF were found to associate with regulatory regions of the human HO-1 gene in the kidney following rhabdomyolysis. Chromosome conformation capture and ChIP-loop assays confirmed this in the formation of chromatin looping in vivo. Thus, these bacterial artificial chromosome humanized HO-1 mice are a valuable model to study the human HO-1 gene, providing insight to the in vivo architecture of the gene in acute kidney injury and other diseases. [ABSTRACT FROM AUTHOR]

Published
2012
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9. Summary of the International Conference on Onco-Nephrology: an emerging field in medicine.

Author

Capasso A, Benigni A, Capitanio U, Danesh FR, Di Marzo V, Gesualdo L, Grandaliano G, Jaimes EA, Malyszko J, Perazella MA, Qian Q, Ronco P, Rosner MH, Trepiccione F, Viggiano D, Zoccali C, and Capasso G

Subjects
Acute Kidney Injury epidemiology, Acute Kidney Injury etiology, Congresses as Topic, Faculty, Humans, Kidney Transplantation adverse effects, Medical Oncology trends, Neoplasms complications, Neoplasms epidemiology, Nephrologists, Nephrology trends, Oncologists, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology, Acute Kidney Injury therapy, Medical Oncology methods, Neoplasms therapy, Nephrology methods, Renal Insufficiency, Chronic therapy
Abstract

Onco-nephrology is an emerging field in medicine. Patients with cancer may suffer from kidney diseases because of the cancer itself and cancer-related therapy. It is critical for nephrologists to be knowledgeable of cancer biology and therapy in order to be fully integrated in the multidisciplinary team and optimally manage patients with cancer and kidney diseases. In a recent international meeting, the key issues in this challenging clinical interface were addressed, including many unresolved basic science questions, such as the high tumor incidence in kidney transplant recipients. To this end, 70 highly qualified faculty members were gathered from all over the world to discuss these issues in 8 plenary sessions, including 5 keynote lectures. In addition, 48 young nephrologists and oncologists were invited to present their original observations that were highlighted in 2 large poster sessions., (Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)

Published
2019
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10. Nanomedicines for kidney diseases.

Author

Williams RM, Jaimes EA, and Heller DA

Subjects
Humans, Nanoparticles chemistry, Renal Elimination, Drug Delivery Systems methods, Kidney drug effects, Kidney Diseases therapy, Nanomedicine methods, Nanoparticles therapeutic use
Abstract

Nanomedicines have been the subject of great interest for the treatment, diagnosis, and research of disease; however, few specifically address kidney disorders. Nanotechnology can confer significant benefits to medicine, such as the targeted delivery of drugs to specific tissues. Nanomedicines in the clinic have increased drug solubility, reduced off-target side effects, and provided novel diagnostic tools. There is an increasing cohort of nanomaterials that may have implications for kidney disease. Here, we review nanomaterial properties that are potentially applicable to kidney research and therapy, and we highlight clinical areas of need that may benefit from kidney nanomedicines., (Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)

Published
2016
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