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4 results on '"Jen Jar Lin"'

1. Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome

Author

Debbie S. Gipson, Howard Trachtman, Anne Waldo, Keisha L. Gibson, Sean Eddy, Katherine M. Dell, Tarak Srivastava, Kevin V. Lemley, Larry A. Greenbaum, Sangeeta Hingorani, Kevin E. Meyers, Frederick J. Kaskel, Kimberly J. Reidy, Christine B. Sethna, Cheryl L. Tran, Chia-shi Wang, Katherine R. Tuttle, Gia Oh, Alicia M. Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M. Roth, Jonathan P. Troost, Brenda W. Gillespie, Matthew G. Sampson, Matthias Kretzler, and Wenjun Ju

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome. Methods: The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine creatinine (Cr) concentration. Renal epidermal growth factor (EGF) mRNA was measured in the tubular compartment microdissected from kidney biopsy cores from a subset of patients. Linear mixed models were used to test if baseline uEGF/Cr and EGF mRNA expression were associated with change in estimated glomerular filtration rate (eGFR) over time. Results: Higher uEGF/Cr at baseline was associated with slower eGFR decline during follow-up (median follow-up = 30 months). Halving of uEGF/Cr was associated with a decrease in eGFR slope of 2.0 ml/min per 1.73 m2 per year (P < 0.001) adjusted for age, race, diagnosis, baseline eGFR and proteinuria, and APOL1 genotype. In the biopsied subgroup, uEGF/Cr was correlated with EGF mRNA expression (r = 0.74; P < 0.001), but uEGF/Cr was retained over mRNA expression as the stronger predictor of eGFR slope after multivariable adjustment (decrease in eGFR slope of 1.7 ml/min per 1.73 m2 per year per log2 decrease in uEGF/Cr; P < 0.001). Conclusion: uEGF/Cr may be a useful noninvasive biomarker that can assist in predicting the long-term course of kidney function in children with incident nephrotic syndrome. Keywords: disease progression, epidermal growth factor, focal segmental glomerulosclerosis, nephrotic syndrome, pediatrics

Published
2020
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2. Text Messaging for Disease Monitoring in Childhood Nephrotic Syndrome

Author

Chia-shi Wang, Jonathan P. Troost, Larry A. Greenbaum, Tarak Srivastava, Kimberly Reidy, Keisha Gibson, Howard Trachtman, John D. Piette, Christine B. Sethna, Kevin Meyers, Katherine M. Dell, Cheryl L. Tran, Suzanne Vento, Krishna Kallem, Emily Herreshoff, Sangeeta Hingorani, Kevin Lemley, Gia Oh, Elizabeth Brown, Jen-Jar Lin, Frederick Kaskel, and Debbie S. Gipson

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introduction: There is limited information on effective disease monitoring for prompt interventions in childhood nephrotic syndrome. We examined the feasibility and effectiveness of a novel text messaging system (SMS) for disease monitoring in a multicenter, prospective study. Methods: A total of 127 patients

Published
2019
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3. Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome

Author

Chia-shi Wang, Therese M. Roth, Howard Trachtman, Jennifer Yee, Cheryl L. Tran, Brenda W. Gillespie, Keisha L. Gibson, Katherine R. Tuttle, Anne Waldo, Kevin V. Lemley, Matthew G. Sampson, Sean Eddy, Katherine MacRae Dell, Wenjun Ju, Gia Oh, Kimberly J. Reidy, Jonathan P. Troost, Elizabeth J. Brown, Matthias Kretzler, Sangeeta Hingorani, Frederick J. Kaskel, Larry A. Greenbaum, Kevin E.C. Meyers, Christine B. Sethna, Alicia M. Neu, Debbie S. Gipson, Tarak Srivastava, and Jen Jar Lin

Subjects
medicine.medical_specialty, pediatrics, Urinary system, 030232 urology & nephrology, Urology, Renal function, 030204 cardiovascular system & hematology, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, Focal segmental glomerulosclerosis, disease progression, Epidermal growth factor, Clinical Research, Biopsy, medicine, Minimal change disease, focal segmental glomerulosclerosis, Kidney, medicine.diagnostic_test, business.industry, nephrotic syndrome, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, medicine.anatomical_structure, epidermal growth factor, Nephrology, business, Nephrotic syndrome
Abstract

Introduction Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome. Methods The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine creatinine (Cr) concentration. Renal epidermal growth factor (EGF) mRNA was measured in the tubular compartment microdissected from kidney biopsy cores from a subset of patients. Linear mixed models were used to test if baseline uEGF/Cr and EGF mRNA expression were associated with change in estimated glomerular filtration rate (eGFR) over time. Results Higher uEGF/Cr at baseline was associated with slower eGFR decline during follow-up (median follow-up = 30 months). Halving of uEGF/Cr was associated with a decrease in eGFR slope of 2.0 ml/min per 1.73 m2 per year (P < 0.001) adjusted for age, race, diagnosis, baseline eGFR and proteinuria, and APOL1 genotype. In the biopsied subgroup, uEGF/Cr was correlated with EGF mRNA expression (r = 0.74; P < 0.001), but uEGF/Cr was retained over mRNA expression as the stronger predictor of eGFR slope after multivariable adjustment (decrease in eGFR slope of 1.7 ml/min per 1.73 m2 per year per log2 decrease in uEGF/Cr; P < 0.001). Conclusion uEGF/Cr may be a useful noninvasive biomarker that can assist in predicting the long-term course of kidney function in children with incident nephrotic syndrome., Graphical abstract

Published
2019

4. Text Messaging for Disease Monitoring in Childhood Nephrotic Syndrome

Author

Elizabeth J. Brown, Krishna Kallem, Debbie S. Gipson, Christine B. Sethna, Katherine MacRae Dell, Gia Oh, Kevin E.C. Meyers, Jen Jar Lin, Emily Herreshoff, Keisha L. Gibson, Sangeeta Hingorani, Howard Trachtman, Kevin V. Lemley, John D. Piette, Suzanne Vento, Jonathan P. Troost, Frederick J. Kaskel, Tarak Srivastava, Chia-shi Wang, Larry A. Greenbaum, Kimberly J. Reidy, and Cheryl L. Tran

Subjects
Pediatrics, medicine.medical_specialty, caregivers, Concordance, 030232 urology & nephrology, Psychological intervention, health status, 030204 cardiovascular system & hematology, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, children, Interquartile range, Clinical Research, Text messaging, Medicine, text messaging, Prospective cohort study, mobile health, Response rate (survey), business.industry, nephrotic syndrome, Retention rate, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, 3. Good health, Nephrology, business, Nephrotic syndrome
Abstract

Introduction There is limited information on effective disease monitoring for prompt interventions in childhood nephrotic syndrome. We examined the feasibility and effectiveness of a novel text messaging system (SMS) for disease monitoring in a multicenter, prospective study. Methods A total of 127 patients, Graphical abstract

Published
2019

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