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2. A Focus Group Study of Self-Management in Patients With Glomerular Disease

Author

Carter, Simon A, Teng, Claris, Gutman, Talia, Logeman, Charlotte, Cattran, Dan, Lightstone, Liz, Bagga, Arvind, Barbour, Sean J, Barratt, Jonathan, Boletis, John, Caster, Dawn J, Coppo, Rosanna, Fervenza, Fernando C, Floege, Jürgen, Hladunewich, Michelle A, Hogan, Jonathan J, Kitching, A Richard, Lafayette, Richard A, Malvar, Ana, Radhakrishnan, Jai, Rovin, Brad H, Scholes-Robertson, Nicole, Trimarchi, Hernán, Zhang, Hong, Azukaitis, Karolis, Cho, Yeoungjee, Viecelli, Andrea K, Dunn, Louese, Harris, David, Johnson, David W, Kerr, Peter G, Laboi, Paul, Ryan, Jessica, Shen, Jenny I, Ruiz, Lorena, Wang, Angela Yee-Moon, Lee, Achilles Hoi Kan, Shun, Samuel Fung Ka, Tong, Matthew Ka-Hang, Teixeira-Pinto, Armando, Wilkie, Martin, Alexander, Stephen I, Craig, Jonathan C, Martin, Adam, and Tong, Allison

Subjects
Health Services and Systems, Health Sciences, Behavioral and Social Science, Health Services, Clinical Research, Management of diseases and conditions, 7.1 Individual care needs, Good Health and Well Being, focus groups, glomerulonephritis, personal autonomy, self-management, therapeutic alliance, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionPatients with glomerular disease experience symptoms that impair their physical and mental health while managing their treatments, diet, appointments and monitoring general and specific indicators of health and their illness. We sought to describe the perspectives of patients and their care partners on self-management in glomerular disease.MethodsWe conducted 16 focus groups involving adult patients with glomerular disease (n = 101) and their care partners (n = 34) in Australia, Hong Kong, the United Kingdom, and United States. Transcripts were analyzed thematically.ResultsWe identified the following 4 themes: empowered in autonomy (gaining confidence through understanding, taking ownership of disease and treatment, learning a positive health approach); overwhelmed by compounding treatment burdens (financially undermined and depleted, demoralized by side effects and harms, frustrated by fragmented and inflexible care, fear of possible drug harms); striving for stability and normalcy (making personal sacrifices, maximizing life participation, attentiveness to bodily signs, avoiding precarious health states, integrating medicines into routines); and necessity of health-sustaining relationships (buoyed by social support, fulfilling meaningful responsibilities, sharing and normalizing experiences, seeking a trusting and respectful alliance).ConclusionPatients with glomerular disease and their care partners value their capacity for autonomy and disease ownership, stability of their health, and relationships that support self-management. Strategies directed at strengthening these factors may increase self-efficacy and improve the care and outcomes for patients with glomerular disease.

Published
2022

3. Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy

Author

Tam, Frederick W.K., Tumlin, James, Barratt, Jonathan, Rovin, Brad H., Roberts, Ian S.D., Roufosse, Candice, Cook, H. Terence, Bhangal, Gurjeet, Brown, Alison L., Busch, Martin, Dudhiya, Fayaz, Duliege, Anne-Marie, Fraser, Donald J., Gale, Daniel P., Huang, Chiu-Ching, Lai, Ping-Chin, Lee, Meng, Masuda, Esteban S., McAdoo, Stephen P., Rosenkranz, Alexander R., Sommerer, Claudia, Sunder-Plassmann, Gere, Szeto, Cheuk-Chun, Tang, Sydney C.W., Williamson, Don E., Willcocks, Lisa, Vielhauer, Volker, Kim, Min Jeong, Todd, Leslie, Zayed, Hany, Tong-Starksen, Sandra, and Lafayette, Richard

Published
2023
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6. Persistent Disease Activity in Patients With Long-Standing Glomerular Disease

Author

Ahn, Wooin, Appel, Gerald B., Babayev, Revekka, Batal, Ibrahim, Bomback, Andrew S., Brown, Eric, Campenot, Eric S., Canetta, Pietro, Chan, Brenda, Chatterjee, Debanjana, D’Agati, Vivette D., Delbarba, Elisa, Fernandez, Hilda, Foroncewicz, Bartosz, Gharavi, Ali G., Ghiggeri, Gian Marco, Hines, William H., Jain, Namrata G., Kil, Byum Hee, Kiryluk, Krzysztof, Lau, Wai L., Lin, Fangming, Lugani, Francesca, Marasa, Maddalena, Markowitz, Glen, Mohan, Sumit, Mu, Xueru, Mucha, Krzysztof, Nickolas, Thomas L., Piva, Stacy, Radhakrishnan, Jai, Rao, Maya K., Sanna-Cherchi, Simone, Santoriello, Dominick, Stokes, Michael B., Yu, Natalie, Valeri, Anthony M., Zviti, Ronald, Greenbaum, Larry A., Smoyer, William E., Al-Uzri, Amira, Ashoor, Isa, Aviles, Diego, Baracco, Rossana, Barcia, John, Bartosh, Sharon, Belsha, Craig, Bowers, Corinna, Braun, Michael C., Chishti, Aftab, Claes, Donna, Cramer, Carl, Davis, Keefe, Erkan, Elif, Feig, Daniel, Freundlich, Michael, Gbadegesin, Rasheed, Hanna, Melisha, Hidalgo, Guillermo, Hunley, Tracy E., Jain, Amrish, Kallash, Mahmoud, Khalid, Myda, Klein, Jon B., Lane, Jerome C., Mahan, John, Mathews, Nisha, Nester, Carla, Pan, Cynthia, Patterson, Larry, Patel, Hiren, Revell, Adelaide, Rheault, Michelle N., Silva, Cynthia, Sreedharan, Rajasree, Srivastava, Tarak, Steinke, Julia, Twombley, Katherine, Wenderfer, Scott E., Vasylyeva, Tetyana L., Weaver, Donald J., Wong, Craig S., Almaani, Salem, Ayoub, Isabelle, Budisavljevic, Milos, Derebail, Vimal, Fatima, Huma, Falk, Ronald, Fogo, Agnes, Gehr, Todd, Gibson, Keisha, Glenn, Dorey, Harris, Raymond, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Julian, Bruce, Kidd, Jason, Laurin, Louis-Philippe, Massey, H. Davis, Mottl, Amy, Nachman, Patrick, Nadasdy, Tibor, Novak, Jan, Parikh, Samir, Pichette, Vincent, Poulton, Caroline, Powell, Thomas Brian, Renfrow, Matthew, Rizk, Dana, Rovin, Brad, Royal, Virginie, Saha, Manish, Sanghani, Neil, Self, Sally, Adler, Sharon, Alpers, Charles, Matar, Raed Bou, Brown, Elizabeth, Cattran, Daniel, Choi, Michael, Dell, Katherine M., Dukkipati, Ram, Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal, Gipson, Patrick, Hasely, Leah, Hingorani, Sangeeta, Hladunewich, Michelle, Hogan, Jonathan, Holzman, Lawrence B., Jefferson, J. Ashley, Jhaveri, Kenar, Johnstone, Duncan B., Kaskel, Frederick, Kogan, Amy, Kopp, Jeffrey, Lafayette, Richard, Lemley, Kevin V., Malaga-Dieguez, Laura, Meyers, Kevin, Neu, Alicia, O’Shaughnessy, Michelle Marie, O’Toole, John F., Parekh, Rulan, Reich, Heather, Reidy, Kimberly, Rondon, Helbert, Sambandam, Kamalanathan K., Sedor, John R., Selewski, David T., Sethna, Christine B., Schelling, Jeffrey, Sperati, John C., Swiatecka-Urban, Agnes, Trachtman, Howard, Tuttle, Katherine R., Weisstuch, Joseph, Vento, Suzanne, Zhdanova, Olga, Gillespie, Brenda, Gipson, Debbie S., Hill-Callahan, Peg, Helmuth, Margaret, Herreshoff, Emily, Kretzler, Matthias, Lienczewski, Chrysta, Mansfield, Sarah, Mariani, Laura, Nast, Cynthia C., Robinson, Bruce M., Troost, Jonathan, Wladkowski, Matthew, Zee, Jarcy, Zinsser, Dawn, Guay-Woodford, Lisa M., Canetta, Pietro A., Piva, Stacy E., Gibson, Keisha L., Hladunewich, Michelle A., Hogan, Jonathan J., Julian, Bruce A., Kidd, Jason M., Nachman, Patrick H., Rizk, Dana V., and Sanghani, Neil S.

Published
2020
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7. WCN24-2099 BASELINE CHARACTERISTICS OF THE ALIGN TRIAL: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF ATRASENTAN IN PATIENTS WITH IGAN

Author

Heerspink, Hiddo J.L., primary, Jardine, Meg, additional, Kohan, Donald E., additional, Lafayette, Richard A., additional, Levin, Adeera, additional, Liew, Adrian, additional, Zhang, Hong, additional, Gray, Todd, additional, Sheth, Khushboo, additional, Camargo, Marianne, additional, Renfurm, Ronny, additional, King, Andrew, additional, and Barratt, Jonathan, additional

Published
2024
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8. WCN24-1688 SELF-REPORTED QUALITY OF LIFE IN COMPLEMENT 3 GLOMERULOPATHY PATIENTS DELINEATED BY CKD STAGE: A REAL-WORLD, MULTI-COUNTRY SURVEY

Author

Lafayette, Richard, primary, Sidhu, Raisa, additional, Proudfoot, Clare, additional, Pannagl, Katharina, additional, Ndife, Briana, additional, Smeets, Serge, additional, Murphy, Kathleen, additional, Przybysz, Raymond, additional, de Courcy, Jonathan, additional, Libby, Susanna, additional, and Sinha, Smeeta, additional

Published
2024
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9. WCN24-1294 ATACICEPT REDUCES HEMATURIA AND SERUM GD-IGA1, BOTH ASSOCIATED WITH LONG-TERM RENAL OUTCOMES IN IGA NEPHROPATHY: 36-WEEK RESULTS FROM THE PHASE 2B ORIGIN STUDY

Author

Barratt, Jonathan, primary, Maes, Bart, additional, Lin, Celia, additional, Wei, Xuelian, additional, Barbour, Sean, additional, Phoon, Richard, additional, Kim, Sung Gyun, additional, Tesar, Vladimir, additional, Floege, Jürgen, additional, Jha, Vivekanand, additional, and Lafayette, Richard, additional

Published
2024
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11. WCN24-1674 NEFECON TREATMENT RESPONSE IN ASIAN AND WHITE PATIENT POPULATIONS WITH IMMUNOGLOBULIN A NEPHROPATHY: A 2YEAR ANALYSIS OF THE PHASE III NEFIGARD TRIAL

Author

Barratt, Jonathan, primary, Kristensen, Jens, additional, Stone, Andrew, additional, Floege, Jürgen, additional, Tesař, Vladimír, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Eren, Necmi, additional, Paliege, Alexander, additional, Reich, Heather N., additional, Rovin, Brad H., additional, and Lafayette, Richard, additional

Published
2024
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12. WCN24-1799 HEMATURIA RESOLUTION WITH THE APRIL-BLOCKING MONOCLONAL ANTIBODY, SIBEPRENLIMAB, IN PATIENTS WITH IgA NEPHROPATHY IN A PHASE 2 RANDOMIZED CONTROLLED TRIAL

Author

Barratt, Jonathan, primary, Lafayette, Richard, additional, Suzuki, Hitoshi, additional, Melamadothil, Sreelatha, additional, Kooeinga, Laura, additional, Herath, Chula, additional, Wong, Muh Geot, additional, Oldach, David, additional, Schachter, Asher, additional, Mathur, Mohit, additional, and Suzuki, Yusuke, additional

Published
2024
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14. WCN24-1774 eGFR DECLINE IN PATIENTS WITH IgAN TREATED WITH NEFECON OR PLACEBO: RESULTS FROM THE 2-YEAR NefIgArd PHASE 3 TRIAL

Author

Lafayette, Richard, primary, Kristensen, Jens, additional, Stone, Andrew, additional, Floege, Jürgen, additional, Tesař, Vladimír, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Eren, Necmi, additional, Paliege, Alexander, additional, Reich, Heather N., additional, Rovin, Brad H., additional, and Barratt, Jonathan, additional

Published
2024
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15. WCN24-1680 PREVALENCE AND CLINICAL CHARACTERISTICS OF KIDNEY TRANSPLANTS IN COMPLEMENT 3 GLOMERULOPATHY PATIENTS: RESULTS FROM A REAL-WORLD, MULTI-COUNTRY SURVEY

Author

Lafayette, Richard, primary, Sidhu, Raisa, additional, Proudfoot, Clare, additional, Pannagl, Katharina, additional, Ndife, Briana, additional, Smeets, Serge, additional, Murphy, Kathleen, additional, Przybysz, Raymond, additional, de Courcy, Jonathan, additional, Libby, Susanna, additional, and Sinha, Smeeta, additional

Published
2024
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17. WCN24-1776 NEFECON EFFECT ON QUALITY OF LIFE IN PATIENTS WITH IgAN: SF-36 RESULTS FROM THE PHASE 3 NeFIgArd TRIAL

Author

Barratt, Jonathan, primary, Kristensen, Jens, additional, Stone, Andrew, additional, Floege, Jürgen, additional, Tesař, Vladimír, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Eren, Necmi, additional, Paliege, Alexander, additional, Reich, Heather N., additional, Rovin, Brad H., additional, and Lafayette, Richard, additional

Published
2024
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20. WCN24-1414 ORIGIN 3: PIVOTAL PHASE 3 STUDY EVALUATING EFFECT OF ATACICEPT VS PLACEBO ON PROTEINURIA AND RENAL FUNCTION PRESERVATION IN IGA NEPHROPATHY

Author

Barratt, Jonathan, primary, Maes, Bart, additional, Israni, Rubeen, additional, Wei, Xuelian, additional, Floege, Jürgen, additional, Jha, Vivekanand, additional, Tesar, Vladimir, additional, Zhang, Hong, additional, Barbour, Sean, additional, Suzuki, Hitoshi, additional, Trimarchi, Hernan, additional, Lin, Celia, additional, and Lafayette, Richard, additional

Published
2024
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21. WCN24-1777 NEFECON TREATMENT PROVIDES KIDNEY BENEFITS FOR PATIENTS WITH IgAN THAT EXTEND TO THOSE WITH LOW LEVELS OF UPCR: A SUB-ANALYSIS OF THE PHASE III NefIgArd TRIAL

Author

Barratt, Jonathan, primary, Kristensen, Jens, additional, Stone, Andrew, additional, Floege, Jürgen, additional, Tesař, Vladimír, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Eren, Necmi, additional, Paliege, Alexander, additional, Reich, Heather N., additional, Rovin, Brad H., additional, and Lafayette, Richard, additional

Published
2024
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23. Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study

Author

Gharavi, Ali, Ahn, Wooin, Appel, Gerald B., Avasare, Rupali S., Babayev, Revekka, Batal, Ibrahim, Bomback, Andrew S., Brown, Eric, Campenot, Eric S., Canetta, Pietro, Chan, Brenda, D’Agati, Vivette D., Fernandez, Hilda, Foroncewicz, Bartosz, Ghiggeri, Gian Marco, Hines, William H., Jain, Namrata G., Kiryluk, Krzysztof, Lin, Fangming, Lugani, Francesca, Marasa, Maddalena, Markowitz, Glen, Mohan, Sumit, Mucha, Krzysztof, Nickolas, Thomas L., Radhakrishnan, Jai, Rao, Maya K., Regunathan-Shenk, Renu, Sanna-Cherchi, Simone, Santoriello, Dominick, Stokes, Michael B., Yu, Natalie, Valeri, Anthony M., Zviti, Ronald, Greenbaum, Larry A., Smoyer, William E., Al-Uzri, Amira, Ashoor, Isa, Aviles, Diego, Baracco, Rossana, Barcia, John, Bartosh, Sharon, Belsha, Craig, Braun, Michael C., Chishti, Aftab, Claes, Donna, Cramer, Carl, Davis, Keefe, Erkan, Elif, Feig, Daniel, Freundlich, Michael, Hanna, Melisha, Hidalgo, Guillermo, Jain, Amrish, Khalid, Myda, Kallash, Mahmoud, Lane, Jerome C., Mahan, John, Mathews, Nisha, Nester, Carla, Pan, Cynthia, Patel, Hiren, Revell, Adelaide, Sreedharan, Rajasree, Steinke, Julia, Wenderfer, Scott E., Wong, Craig S., Falk, Ronald, Cook, William, Derebail, Vimal, Fogo, Agnes, Gasim, Adil, Gehr, Todd, Harris, Raymond, Kidd, Jason, Laurin, Louis-Philippe, Pendergraft, Will, Pichette, Vincent, Powell, Thomas Brian, Renfrow, Matthew B., Royal, Virginie, Holzman, Lawrence B., Adler, Sharon, Alpers, Charles, Matar, Raed Bou, Brown, Elizabeth, Cattran, Daniel, Choi, Michael, Dell, Katherine M., Dukkipati, Ram, Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal, Gipson, Patrick, Hasely, Leah, Hingorani, Sangeeta, Hladunewich, Michelle A., Hogan, Jonathan, Jefferson, J. Ashley, Jhaveri, Kenar, Johnstone, Duncan B., Kaskel, Frederick, Kogan, Amy, Kopp, Jeffrey, Lemley, Kevin V., Dieguez, Laura Malaga, Meyers, Kevin, Neu, Alicia, O’Shaughnessy, Michelle Marie, O’Toole, John F., Parekh, Rulan, Reich, Heather, Reidy, Kimberly, Rondon, Helbert, Sambandam, Kamalanathan K., Sedor, John R., Selewski, David T., Sethna, Christine B., Schelling, Jeffrey, Sperati, C. John, Swiatecka-Urban, Agnes, Trachtman, Howard, Tuttle, Katherine R., Weisstuch, Joseph, Zhdanova, Olga, Gillespie, Brenda, Gipson, Debbie S., Kretzler, Matthias, Robinson, Bruce M., Barisoni, Laura, Mansfield, Sarah, Mariani, Laura, Nast, Cynthia C., Wladkowski, Matthew, Zee, Jarcy, Guay-Woodford, Lisa M., Ambruzs, Josephine M., Cai, Yi, Cattran, Daniel C., Chishti, Aftab S., D'Agati, Vivette D., D'Alessandri-Silva, Cynthia J., Gbadegesin, Rasheed A., Hogan, Jonathan J., Iragorri, Sandra, Jennette, J. Charles, Julian, Bruce A., Lafayette, Richard A., Liapis, Helen, Mansfield, Sarah A., Mason, Sherene, Nachman, Patrick H., Nester, Carla M., Noone, Damien G., Novak, Jan, O'Shaughnessy, Michelle M., Reich, Heather N., Rheault, Michelle N., Rizk, Dana V., Saha, Manish K., Sanghani, Neil S., Srivastava, Tarak, Swiatecka-Urban, Agnieszka, Twombley, Katherine, Vasylyeva, Tetyana L., Weaver, Donald J., Yin, Hong, Falk, Ronald J., Gharavi, Ali G., Gillespie, Brenda W., and Flessner, Michael

Published
2018
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24. NephCure Accelerating Cures Institute: A Multidisciplinary Consortium to Improve Care for Nephrotic Syndrome

Author

Gipson, Debbie S., Selewski, David T., Massengill, Susan F., Modes, Mary Margaret, Desmond, Hailey, Lee, Lauren, Kamil, Elaine, Elliott, Matthew R., Adler, Sharon G., Oh, Gia, Lafayette, Richard A., Gipson, Patrick E., Sinha, Aditi, Bagga, Arvind, Pesenson, Anne, Courtlandt, Cheryl, Spino, Cathie, Eikstadt, Richard, Pitter, Renée, Attalla, Samara, Waldo, Anne, Winneker, Richard, Carlozzi, Noelle E., Troost, Jonathan P., Smokler, Irving, and Stone, Mark

Published
2018
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27. A Focus Group Study of Self-Management in Patients With Glomerular Disease

Author

Carter, Simon A., primary, Teng, Claris, additional, Gutman, Talia, additional, Logeman, Charlotte, additional, Cattran, Dan, additional, Lightstone, Liz, additional, Bagga, Arvind, additional, Barbour, Sean J., additional, Barratt, Jonathan, additional, Boletis, John, additional, Caster, Dawn J., additional, Coppo, Rosanna, additional, Fervenza, Fernando C., additional, Floege, Jürgen, additional, Hladunewich, Michelle A., additional, Hogan, Jonathan J., additional, Kitching, A. Richard, additional, Lafayette, Richard A., additional, Malvar, Ana, additional, Radhakrishnan, Jai, additional, Rovin, Brad H., additional, Scholes-Robertson, Nicole, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Azukaitis, Karolis, additional, Cho, Yeoungjee, additional, Viecelli, Andrea K., additional, Dunn, Louese, additional, Harris, David, additional, Johnson, David W., additional, Kerr, Peter G., additional, Laboi, Paul, additional, Ryan, Jessica, additional, Shen, Jenny I., additional, Ruiz, Lorena, additional, Wang, Angela Yee-Moon, additional, Lee, Achilles Hoi Kan, additional, Ka Shun, Samuel Fung, additional, Ka-Hang Tong, Matthew, additional, Teixeira-Pinto, Armando, additional, Wilkie, Martin, additional, Alexander, Stephen I., additional, Craig, Jonathan C., additional, Martin, Adam, additional, and Tong, Allison, additional

Published
2021
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28. Why Target the Gut to Treat IgA Nephropathy?

Author

Barratt, Jonathan, primary, Rovin, Brad H., additional, Cattran, Daniel, additional, Floege, Jürgen, additional, Lafayette, Richard, additional, Tesar, Vladimir, additional, Trimarchi, Hernán, additional, and Zhang, Hong, additional

Published
2020
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29. Persistent Disease Activity in Patients With Long-Standing Glomerular Disease

Author

Delbarba, Elisa, primary, Marasa, Maddalena, additional, Canetta, Pietro A., additional, Piva, Stacy E., additional, Chatterjee, Debanjana, additional, Kil, Byum Hee, additional, Mu, Xueru, additional, Gibson, Keisha L., additional, Hladunewich, Michelle A., additional, Hogan, Jonathan J., additional, Julian, Bruce A., additional, Kidd, Jason M., additional, Laurin, Louis-Philippe, additional, Nachman, Patrick H., additional, Rheault, Michelle N., additional, Rizk, Dana V., additional, Sanghani, Neil S., additional, Trachtman, Howard, additional, Wenderfer, Scott E., additional, Gharavi, Ali G., additional, Bomback, Andrew S., additional, Ahn, Wooin, additional, Appel, Gerald B., additional, Babayev, Revekka, additional, Batal, Ibrahim, additional, Brown, Eric, additional, Campenot, Eric S., additional, Canetta, Pietro, additional, Chan, Brenda, additional, D’Agati, Vivette D., additional, Delbarba, Elisa, additional, Fernandez, Hilda, additional, Foroncewicz, Bartosz, additional, Ghiggeri, Gian Marco, additional, Hines, William H., additional, Jain, Namrata G., additional, Kiryluk, Krzysztof, additional, Lau, Wai L., additional, Lin, Fangming, additional, Lugani, Francesca, additional, Markowitz, Glen, additional, Mohan, Sumit, additional, Mucha, Krzysztof, additional, Nickolas, Thomas L., additional, Piva, Stacy, additional, Radhakrishnan, Jai, additional, Rao, Maya K., additional, Sanna-Cherchi, Simone, additional, Santoriello, Dominick, additional, Stokes, Michael B., additional, Yu, Natalie, additional, Valeri, Anthony M., additional, Zviti, Ronald, additional, Greenbaum, Larry A., additional, Smoyer, William E., additional, Al-Uzri, Amira, additional, Ashoor, Isa, additional, Aviles, Diego, additional, Baracco, Rossana, additional, Barcia, John, additional, Bartosh, Sharon, additional, Belsha, Craig, additional, Bowers, Corinna, additional, Braun, Michael C., additional, Chishti, Aftab, additional, Claes, Donna, additional, Cramer, Carl, additional, Davis, Keefe, additional, Erkan, Elif, additional, Feig, Daniel, additional, Freundlich, Michael, additional, Gbadegesin, Rasheed, additional, Hanna, Melisha, additional, Hidalgo, Guillermo, additional, Hunley, Tracy E., additional, Jain, Amrish, additional, Kallash, Mahmoud, additional, Khalid, Myda, additional, Klein, Jon B., additional, Lane, Jerome C., additional, Mahan, John, additional, Mathews, Nisha, additional, Nester, Carla, additional, Pan, Cynthia, additional, Patterson, Larry, additional, Patel, Hiren, additional, Revell, Adelaide, additional, Silva, Cynthia, additional, Sreedharan, Rajasree, additional, Srivastava, Tarak, additional, Steinke, Julia, additional, Twombley, Katherine, additional, Vasylyeva, Tetyana L., additional, Weaver, Donald J., additional, Wong, Craig S., additional, Almaani, Salem, additional, Ayoub, Isabelle, additional, Budisavljevic, Milos, additional, Derebail, Vimal, additional, Fatima, Huma, additional, Falk, Ronald, additional, Fogo, Agnes, additional, Gehr, Todd, additional, Gibson, Keisha, additional, Glenn, Dorey, additional, Harris, Raymond, additional, Hogan, Susan, additional, Jain, Koyal, additional, Jennette, J. Charles, additional, Julian, Bruce, additional, Kidd, Jason, additional, Massey, H. Davis, additional, Mottl, Amy, additional, Nachman, Patrick, additional, Nadasdy, Tibor, additional, Novak, Jan, additional, Parikh, Samir, additional, Pichette, Vincent, additional, Poulton, Caroline, additional, Powell, Thomas Brian, additional, Renfrow, Matthew, additional, Rizk, Dana, additional, Rovin, Brad, additional, Royal, Virginie, additional, Saha, Manish, additional, Sanghani, Neil, additional, Self, Sally, additional, Adler, Sharon, additional, Alpers, Charles, additional, Matar, Raed Bou, additional, Brown, Elizabeth, additional, Cattran, Daniel, additional, Choi, Michael, additional, Dell, Katherine M., additional, Dukkipati, Ram, additional, Fervenza, Fernando C., additional, Fornoni, Alessia, additional, Gadegbeku, Crystal, additional, Gipson, Patrick, additional, Hasely, Leah, additional, Hingorani, Sangeeta, additional, Hladunewich, Michelle, additional, Hogan, Jonathan, additional, Holzman, Lawrence B., additional, Jefferson, J. Ashley, additional, Jhaveri, Kenar, additional, Johnstone, Duncan B., additional, Kaskel, Frederick, additional, Kogan, Amy, additional, Kopp, Jeffrey, additional, Lafayette, Richard, additional, Lemley, Kevin V., additional, Malaga-Dieguez, Laura, additional, Meyers, Kevin, additional, Neu, Alicia, additional, O’Shaughnessy, Michelle Marie, additional, O’Toole, John F., additional, Parekh, Rulan, additional, Reich, Heather, additional, Reidy, Kimberly, additional, Rondon, Helbert, additional, Sambandam, Kamalanathan K., additional, Sedor, John R., additional, Selewski, David T., additional, Sethna, Christine B., additional, Schelling, Jeffrey, additional, Sperati, John C., additional, Swiatecka-Urban, Agnes, additional, Tuttle, Katherine R., additional, Weisstuch, Joseph, additional, Vento, Suzanne, additional, Zhdanova, Olga, additional, Gillespie, Brenda, additional, Gipson, Debbie S., additional, Hill-Callahan, Peg, additional, Helmuth, Margaret, additional, Herreshoff, Emily, additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Mansfield, Sarah, additional, Mariani, Laura, additional, Nast, Cynthia C., additional, Robinson, Bruce M., additional, Troost, Jonathan, additional, Wladkowski, Matthew, additional, Zee, Jarcy, additional, Zinsser, Dawn, additional, and Guay-Woodford, Lisa M., additional

Published
2020
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32. Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study

Author

Selewski, David T., primary, Ambruzs, Josephine M., additional, Appel, Gerald B., additional, Bomback, Andrew S., additional, Matar, Raed Bou, additional, Cai, Yi, additional, Cattran, Daniel C., additional, Chishti, Aftab S., additional, D'Agati, Vivette D., additional, D'Alessandri-Silva, Cynthia J., additional, Gbadegesin, Rasheed A., additional, Hogan, Jonathan J., additional, Iragorri, Sandra, additional, Jennette, J. Charles, additional, Julian, Bruce A., additional, Khalid, Myda, additional, Lafayette, Richard A., additional, Liapis, Helen, additional, Lugani, Francesca, additional, Mansfield, Sarah A., additional, Mason, Sherene, additional, Nachman, Patrick H., additional, Nast, Cynthia C., additional, Nester, Carla M., additional, Noone, Damien G., additional, Novak, Jan, additional, O'Shaughnessy, Michelle M., additional, Reich, Heather N., additional, Rheault, Michelle N., additional, Rizk, Dana V., additional, Saha, Manish K., additional, Sanghani, Neil S., additional, Sperati, C. 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Published
2018
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33. An Open-Label Pilot Study of Adrenocorticotrophic Hormone in the Treatment of IgA Nephropathy at High Risk of Progression.

Author

Zand L, Canetta P, Lafayette R, Aslam N, Jan N, Sethi S, and Fervenza FC

Abstract

Introduction: IgA nephropathy (IgAN) is the most common glomerulonephritis with high risk of progression to end-stage renal disease in patients with proteinuria >1 g/24 hours. There are no known effective treatments in patients with IgAN., Methods: We conducted a prospective open-label pilot study in patients with IgAN using adrenocorticotrophic hormone (ACTH) (Acthar Gel, Mallinckrodt Pharmaceuticals, Bedminster, NJ) at a dosage of 80 units subcutaneously twice weekly for a total of 6 months and followed patients for a total of 12 months. Patients had to have urinary protein >1 g/24 hours despite adequate renin-angiotensin-aldosterone system (RAAS) blockade and estimated glomerular filtration rate (eGFR) >30 ml/min at enrollment., Results: A total of 19 patients were recruited and followed for 1 year. At baseline, the mean age was 34.9 ± 10.5 years with 11 men and 8 women, and 14 Caucasian and 5 Asian individuals. At 12 months, there was a statistically significant decline in 24-hour urinary protein from 2.6 to 1.3 g ( P  = 0.007) and significant increase in serum albumin (3.79 to 3.93, P  = 0.02). There was no significant change in eGFR (65.5 to 61.1 ml/min, P  = 0.1). There were 0 complete remissions and 8 partial remissions (42%). There were a total of 6 infections: 2 were viral and 4 required antibiotic therapy (2 sinusitis, 1 pneumonia, 1 otitis media). The most common adverse events included acne, hot flashes, soreness, and anxiety., Conclusion: In summary, patients with IgAN with >1 g/24-hour urinary protein and eGFR >30 ml/min had a significant reduction in 24-hour urinary protein with stable eGFR at 12-month follow-up after being treated with 6 months of ACTH., (© 2019 International Society of Nephrology. Published by Elsevier Inc.)

Published
2019
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